Difference between revisions of "CPS1-IT1"

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(Created page with "==Annotated Information== ===Approved Symbol=== CPS1-IT1 ===Approved Name=== CPS1 intronic transcript 1 ===Previous Symbols=== CPS1IT ===Synonyms=== PRO0132, CPS1-IT ===Chromo...")
 
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==Annotated Information==
 
==Annotated Information==
−
===Approved Symbol===
+
===Name===
−
CPS1-IT1
+
Approved Symbol: CPS1-IT1
−
===Approved Name===
+
 
−
CPS1 intronic transcript 1
+
Approved Name: CPS1 intronic transcript 1
−
===Previous Symbols===
+
 
−
CPS1IT
+
Previous Symbols: CPS1IT
−
===Synonyms===
+
 
−
PRO0132, CPS1-IT
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Synonyms: PRO0132, CPS1-IT
 +
 
 +
RefSeq ID: NR_002763
 +
 
 +
Ensembl ID: ENSG00000280837
 +
 
 +
LncBook transcript ID: HSALNT0046602
 
===Chromosome===
 
===Chromosome===
 
2q34
 
2q34
−
===RefSeq ID===
+
 
−
NR_002763
+
===Characteristics===
−
===OMIM ID===
+
-
−
_
+
===Function===
−
===Ensembl ID===
+
[[File:CPS1-IT1-fun.png|right|thumb|400px|Overexpression of CPS1-IT1 inhibited cell proliferation in colorectal carcinoma cell lines<ref name="ref1" />.]]
−
ENSG00000280837
+
*CPS1-IT1 significantly reduced cell proliferation, migration and invasion capacities and accelerated cell apoptosis, thereby suppressing epithelial-mesenchymal transition (EMT). An in vivo animal model also demonstrated the tumor-suppressive role of CPS1-IT1.<ref name="ref1" />.
 +
 
 +
===Regulation===
 +
-
 +
===Diseases===
 +
Colorectal carcinoma(CRC)<ref name="ref1" />.
 +
 
 +
===Expression===
 +
[[File:CPS1-IT1-exp.png|right|thumb|400px|Relative expression of CPS1-IT1 in human colorectal carcinoma and adjacent non-cancerous normal tissues as well as in different colorectal carcinoma cell lines of varying metastatic potential<ref name="ref1" />.]]
 +
Expression of
 +
CPS1-IT1 was significantly decreased in CRC tissues and cell lines, and patients with low CPS1-IT1 expression had poor survival outcomes.<ref name="ref1" />.
 +
 
 +
{| class='wikitable' style="text-align:center"
 +
|-
 +
! | Experiment
 +
! | Forward primer
 +
! | Reverse primer
 +
|-
 +
| rowspan="1"|Quantitative real-time PCR
 +
| | 5'-CAC AGA TGA TCC ACG GCG TT- 3'
 +
| | 5'-GCG TGC ATC AAT GAC ACT TCA- 3'<ref name="ref1" />
 +
|}
 +
 
 +
===Evolution===
 +
-
 
===pubmed IDs===
 
===pubmed IDs===
−
12477932
+
12477932, 29145177
 +
==Labs working on this lncRNA==
 +
* Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
 +
==References==
 +
<references>
 +
<ref name="ref1">
 +
Zhang W, Yuan W, Song J, Wang S, Gu X. LncRna CPS1-IT1 Suppresses Cell Proliferation, Invasion and Metastasis in Colorectal Cancer. Cell Physiol Biochem. 2017;44(2):567-580.
 +
</ref>(1)
 +
</references>
 +
 
 
===Sequence===
 
===Sequence===
 
>gi|192807280|ref|NR_002763.2| Homo sapiens CPS1 intronic transcript 1 (CPS1-IT1), long non-coding RNA
 
>gi|192807280|ref|NR_002763.2| Homo sapiens CPS1 intronic transcript 1 (CPS1-IT1), long non-coding RNA
 
<dnaseq>AATAAAACACTTGCTTTTCTTTTTGAGAAAAATTAGGTTCTTTTTCATCTATTTAATTATTGCCCATGTCAAATGCTTGGTTTTGAAAACTGAGGAATTCTATCTGACAAAGATGAAACCAGCTATAGTTGCTTGTAAATCATCCTTTCTAGTGATCACATAAAATGAACAGTAGACAGCAAATAATTTAGGAATTGAACCTATACATTTATCTTATAATTTTGCTGACTTAAGTTTCCCTTTCTTGGTTTATGATGCCAGCAGAACTTCTGTGTAAAATTATAGTCTGTTCTACTGTTCTCAGTTTCAGGCAACTGATTTCAAATGCCTATGAAACCACTCCAATTAAGCCACATGGGGGTGCTAGAAACTTATAGTATGCCAGTCACAGCAGTGGAAAAGACCTGGGGTGGAAAATAGCAGATGTTATTGTGATTTAAATTTCCACTTGACATACGTTCTGATTTTTGGACAAATTCAATGTTTTAATTGAATAGTTTTCGTTACAACCAGAAGGCAGGTTGAGATTCTAACTAAGCATAAATAAGGGTATATTGATAGTGAAAAAGGTCCTTGGAGGATTAAAACAACACACTGTTACAGATCATTTATAATATTTTTCTGACTTCCACATTCTGTTGCATTTATTTGCCGACAATTTGACATTTTCAATCTCCATTTTCTGGCATAAATATATTTGTAAATAGGGATATTTTCTATTGTTCATAATGATCTACATTTAAAACTCTTTATGTAAAGCTTTATATCATTTCAAAAATTTCAAAAACTTACACTTAAAATCATCTCTACTGTATAAATTTGTTTTTGATCCAGGGAGGTTGAAGTGTCTATTATATAGCAAAAGCTAAAGTAAACCTGAAGTGGAACTCACAGATGATCCACGGCGTTAGCAAACCTAAACCCTGAACTCATTATCTGAGTGTCACTTTATGGTTTAATTCCTTTCTTTTTGAAGTGTCATTGATGCACGCATAGCAATTTGATAATGATTGTTATTTAGCGGTATTAGATAAATAACAAGAATAGATGGCCACTAAAGCTACCTGTCTCCATCATTTTGTGGCACATAGGGGTCTGAAGTTGAAAGAATACGACAGCTGATGGAATGAATGTTAAGTATGTAAGGCCTTGAGTTTCCTTGCCCTATTTTAATTATACTCACCATTAGTCTGGGTCTGAGTCCTCTGCTTTTTCTCGGCCCCTCAATATCCAGGGAGGCTTAGTCATCAAGGTACGTACTGCTCCAACAGTAACAAGAGCTCCCTATTAATGACCTATAGCTGACTTACATATTGCGAGTTTGGAGAGAGGCTGAGAAGATTAGTTGTTCTTTTTCATTTGTATTTATTTATGGTTTACTTTGAAGATCTCAACTGCTTCTGTGTTAGAATGGCTGTCTTTAGCTGTAGGCCTAGGAGCTAGCGATTTATTTGGTGTGCGTTCAGAGAACTCCAAAATTCTCCTGCCTCAACATCTATCTCTGCTGCCAATGTACCGCACTCCCTTTGTACTTTTCATAGAGATCCTTGAGAAGACAGGCAGTGGGGCTCTCACTTGGGAAAAGAGAAGTAAATTAAGAGAAAAAATATAGAATGCTAGACGTGGGTTTTCTGGTTCCACCCTTGTGCATTGGAAGGAGCAGACTATGGAGCCAGAGATTGGTGCGCAGTCCTCCCCACTGTAGAATCAGACGTACATCACCTCTTTCATTTCTCCAGATTCATGTTCTTTCTCTTAATCTCTGCTTCTAGTTTTTTTGTGAAGCTTAATTTATATAAGTATAAATGACATCTGACATATTGTGAGGGCCCAAGAAAATTTTTCCTCTTTTCCCCTGAAAATAAAAATGCTACTTGTTGTAATAAAGGTTACTTTATGATTTTAGATATGTATTATATATTATGATTTTAGATATGTAGATATGATAGTTAAATATTTAAAGATTCATTTTCAGACTCACAATTTTTATTTGCTTTTATATTTTGCAATGTATCATTTCTTAATTTCCTTTATGATGCATCACTTATTTTAATATCAGACCTATTTTTTAAAGGAAGCAATTGATAGCTACGATGCAAATGCTATTCTTATTAAAAGATAAATAGCTTTCCCTTATGCTAATGAATAAAAATTCCTACTCTACAGTTGTTAATCAATCTCGAGTTCTAAAGTCCGATAAACACATTTAATAGCAGAGGATGAGCATATCATTAAATTGATGGTCAGTCTCTGACTTGTGTTTACATATAGTCATCTGAAATGAAGTTCAGAATTTGAGTCCCAAA</dnaseq>
 
<dnaseq>AATAAAACACTTGCTTTTCTTTTTGAGAAAAATTAGGTTCTTTTTCATCTATTTAATTATTGCCCATGTCAAATGCTTGGTTTTGAAAACTGAGGAATTCTATCTGACAAAGATGAAACCAGCTATAGTTGCTTGTAAATCATCCTTTCTAGTGATCACATAAAATGAACAGTAGACAGCAAATAATTTAGGAATTGAACCTATACATTTATCTTATAATTTTGCTGACTTAAGTTTCCCTTTCTTGGTTTATGATGCCAGCAGAACTTCTGTGTAAAATTATAGTCTGTTCTACTGTTCTCAGTTTCAGGCAACTGATTTCAAATGCCTATGAAACCACTCCAATTAAGCCACATGGGGGTGCTAGAAACTTATAGTATGCCAGTCACAGCAGTGGAAAAGACCTGGGGTGGAAAATAGCAGATGTTATTGTGATTTAAATTTCCACTTGACATACGTTCTGATTTTTGGACAAATTCAATGTTTTAATTGAATAGTTTTCGTTACAACCAGAAGGCAGGTTGAGATTCTAACTAAGCATAAATAAGGGTATATTGATAGTGAAAAAGGTCCTTGGAGGATTAAAACAACACACTGTTACAGATCATTTATAATATTTTTCTGACTTCCACATTCTGTTGCATTTATTTGCCGACAATTTGACATTTTCAATCTCCATTTTCTGGCATAAATATATTTGTAAATAGGGATATTTTCTATTGTTCATAATGATCTACATTTAAAACTCTTTATGTAAAGCTTTATATCATTTCAAAAATTTCAAAAACTTACACTTAAAATCATCTCTACTGTATAAATTTGTTTTTGATCCAGGGAGGTTGAAGTGTCTATTATATAGCAAAAGCTAAAGTAAACCTGAAGTGGAACTCACAGATGATCCACGGCGTTAGCAAACCTAAACCCTGAACTCATTATCTGAGTGTCACTTTATGGTTTAATTCCTTTCTTTTTGAAGTGTCATTGATGCACGCATAGCAATTTGATAATGATTGTTATTTAGCGGTATTAGATAAATAACAAGAATAGATGGCCACTAAAGCTACCTGTCTCCATCATTTTGTGGCACATAGGGGTCTGAAGTTGAAAGAATACGACAGCTGATGGAATGAATGTTAAGTATGTAAGGCCTTGAGTTTCCTTGCCCTATTTTAATTATACTCACCATTAGTCTGGGTCTGAGTCCTCTGCTTTTTCTCGGCCCCTCAATATCCAGGGAGGCTTAGTCATCAAGGTACGTACTGCTCCAACAGTAACAAGAGCTCCCTATTAATGACCTATAGCTGACTTACATATTGCGAGTTTGGAGAGAGGCTGAGAAGATTAGTTGTTCTTTTTCATTTGTATTTATTTATGGTTTACTTTGAAGATCTCAACTGCTTCTGTGTTAGAATGGCTGTCTTTAGCTGTAGGCCTAGGAGCTAGCGATTTATTTGGTGTGCGTTCAGAGAACTCCAAAATTCTCCTGCCTCAACATCTATCTCTGCTGCCAATGTACCGCACTCCCTTTGTACTTTTCATAGAGATCCTTGAGAAGACAGGCAGTGGGGCTCTCACTTGGGAAAAGAGAAGTAAATTAAGAGAAAAAATATAGAATGCTAGACGTGGGTTTTCTGGTTCCACCCTTGTGCATTGGAAGGAGCAGACTATGGAGCCAGAGATTGGTGCGCAGTCCTCCCCACTGTAGAATCAGACGTACATCACCTCTTTCATTTCTCCAGATTCATGTTCTTTCTCTTAATCTCTGCTTCTAGTTTTTTTGTGAAGCTTAATTTATATAAGTATAAATGACATCTGACATATTGTGAGGGCCCAAGAAAATTTTTCCTCTTTTCCCCTGAAAATAAAAATGCTACTTGTTGTAATAAAGGTTACTTTATGATTTTAGATATGTATTATATATTATGATTTTAGATATGTAGATATGATAGTTAAATATTTAAAGATTCATTTTCAGACTCACAATTTTTATTTGCTTTTATATTTTGCAATGTATCATTTCTTAATTTCCTTTATGATGCATCACTTATTTTAATATCAGACCTATTTTTTAAAGGAAGCAATTGATAGCTACGATGCAAATGCTATTCTTATTAAAAGATAAATAGCTTTCCCTTATGCTAATGAATAAAAATTCCTACTCTACAGTTGTTAATCAATCTCGAGTTCTAAAGTCCGATAAACACATTTAATAGCAGAGGATGAGCATATCATTAAATTGATGGTCAGTCTCTGACTTGTGTTTACATATAGTCATCTGAAATGAAGTTCAGAATTTGAGTCCCAAA</dnaseq>

Revision as of 05:02, 9 August 2019

Annotated Information

Name

Approved Symbol: CPS1-IT1

Approved Name: CPS1 intronic transcript 1

Previous Symbols: CPS1IT

Synonyms: PRO0132, CPS1-IT

RefSeq ID: NR_002763

Ensembl ID: ENSG00000280837

LncBook transcript ID: HSALNT0046602

Chromosome

2q34

Characteristics

-

Function

Overexpression of CPS1-IT1 inhibited cell proliferation in colorectal carcinoma cell lines[1].
  • CPS1-IT1 significantly reduced cell proliferation, migration and invasion capacities and accelerated cell apoptosis, thereby suppressing epithelial-mesenchymal transition (EMT). An in vivo animal model also demonstrated the tumor-suppressive role of CPS1-IT1.[1].

Regulation

-

Diseases

Colorectal carcinoma(CRC)[1].

Expression

Relative expression of CPS1-IT1 in human colorectal carcinoma and adjacent non-cancerous normal tissues as well as in different colorectal carcinoma cell lines of varying metastatic potential[1].

Expression of CPS1-IT1 was significantly decreased in CRC tissues and cell lines, and patients with low CPS1-IT1 expression had poor survival outcomes.[1].

Experiment Forward primer Reverse primer
Quantitative real-time PCR 5'-CAC AGA TGA TCC ACG GCG TT- 3' 5'-GCG TGC ATC AAT GAC ACT TCA- 3'[1]

Evolution

-

pubmed IDs

12477932, 29145177

Labs working on this lncRNA

  • Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Zhang W, Yuan W, Song J, Wang S, Gu X. LncRna CPS1-IT1 Suppresses Cell Proliferation, Invasion and Metastasis in Colorectal Cancer. Cell Physiol Biochem. 2017;44(2):567-580.

Sequence

>gi|192807280|ref|NR_002763.2| Homo sapiens CPS1 intronic transcript 1 (CPS1-IT1), long non-coding RNA

000001 AATAAAACAC TTGCTTTTCT TTTTGAGAAA AATTAGGTTC TTTTTCATCT ATTTAATTAT TGCCCATGTC AAATGCTTGG 000080
000081 TTTTGAAAAC TGAGGAATTC TATCTGACAA AGATGAAACC AGCTATAGTT GCTTGTAAAT CATCCTTTCT AGTGATCACA 000160
000161 TAAAATGAAC AGTAGACAGC AAATAATTTA GGAATTGAAC CTATACATTT ATCTTATAAT TTTGCTGACT TAAGTTTCCC 000240
000241 TTTCTTGGTT TATGATGCCA GCAGAACTTC TGTGTAAAAT TATAGTCTGT TCTACTGTTC TCAGTTTCAG GCAACTGATT 000320
000321 TCAAATGCCT ATGAAACCAC TCCAATTAAG CCACATGGGG GTGCTAGAAA CTTATAGTAT GCCAGTCACA GCAGTGGAAA 000400
000401 AGACCTGGGG TGGAAAATAG CAGATGTTAT TGTGATTTAA ATTTCCACTT GACATACGTT CTGATTTTTG GACAAATTCA 000480
000481 ATGTTTTAAT TGAATAGTTT TCGTTACAAC CAGAAGGCAG GTTGAGATTC TAACTAAGCA TAAATAAGGG TATATTGATA 000560
000561 GTGAAAAAGG TCCTTGGAGG ATTAAAACAA CACACTGTTA CAGATCATTT ATAATATTTT TCTGACTTCC ACATTCTGTT 000640
000641 GCATTTATTT GCCGACAATT TGACATTTTC AATCTCCATT TTCTGGCATA AATATATTTG TAAATAGGGA TATTTTCTAT 000720
000721 TGTTCATAAT GATCTACATT TAAAACTCTT TATGTAAAGC TTTATATCAT TTCAAAAATT TCAAAAACTT ACACTTAAAA 000800
000801 TCATCTCTAC TGTATAAATT TGTTTTTGAT CCAGGGAGGT TGAAGTGTCT ATTATATAGC AAAAGCTAAA GTAAACCTGA 000880
000881 AGTGGAACTC ACAGATGATC CACGGCGTTA GCAAACCTAA ACCCTGAACT CATTATCTGA GTGTCACTTT ATGGTTTAAT 000960
000961 TCCTTTCTTT TTGAAGTGTC ATTGATGCAC GCATAGCAAT TTGATAATGA TTGTTATTTA GCGGTATTAG ATAAATAACA 001040
001041 AGAATAGATG GCCACTAAAG CTACCTGTCT CCATCATTTT GTGGCACATA GGGGTCTGAA GTTGAAAGAA TACGACAGCT 001120
001121 GATGGAATGA ATGTTAAGTA TGTAAGGCCT TGAGTTTCCT TGCCCTATTT TAATTATACT CACCATTAGT CTGGGTCTGA 001200
001201 GTCCTCTGCT TTTTCTCGGC CCCTCAATAT CCAGGGAGGC TTAGTCATCA AGGTACGTAC TGCTCCAACA GTAACAAGAG 001280
001281 CTCCCTATTA ATGACCTATA GCTGACTTAC ATATTGCGAG TTTGGAGAGA GGCTGAGAAG ATTAGTTGTT CTTTTTCATT 001360
001361 TGTATTTATT TATGGTTTAC TTTGAAGATC TCAACTGCTT CTGTGTTAGA ATGGCTGTCT TTAGCTGTAG GCCTAGGAGC 001440
001441 TAGCGATTTA TTTGGTGTGC GTTCAGAGAA CTCCAAAATT CTCCTGCCTC AACATCTATC TCTGCTGCCA ATGTACCGCA 001520
001521 CTCCCTTTGT ACTTTTCATA GAGATCCTTG AGAA