Difference between revisions of "PAXIP1-DT"
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===Function=== | ===Function=== | ||
The lncRNA PAXIP1-DT/ETS1/KIF14 axis as a therapeutic target for glioma treatment,due to its role in controlling the migration and invasion of glioma cells and its angiogenesis.<ref name="ref1" /> | The lncRNA PAXIP1-DT/ETS1/KIF14 axis as a therapeutic target for glioma treatment,due to its role in controlling the migration and invasion of glioma cells and its angiogenesis.<ref name="ref1" /> | ||
| − | ===Regulation=== | + | ===Regulation=== |
| + | [[File: PAXIP1-DT.jpeg|thumb|300px| Silencing of lncRNA PAXIP1-DT inhibits migration, invasion, and angiogenesis of glioma cells.<ref name="ref1"/>]] | ||
PAXIP1-DT can controll the migration and invasion of glioma cells and its angiogenesis.<ref name="ref1" /> | PAXIP1-DT can controll the migration and invasion of glioma cells and its angiogenesis.<ref name="ref1" /> | ||
Revision as of 02:21, 19 February 2021
Long non-coding RNA PAXIP1-DT facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression.[1]
Contents
Annotated Information
Name
Approved symbol：PAXIP1-DT
Approved name：PAXIP1 divergent transcript
HGNC ID HGNC:27328
Previous name：PAXIP1 antisense RNA 1 (head to head)
RefSeq ID：NR_028090
Prev_symbol：PAXIP1-AS1
Characteristics
LncRNA PAXIP1-DT was mainly distributed in the nucleus of glioma cells.[1]
Function
The lncRNA PAXIP1-DT/ETS1/KIF14 axis as a therapeutic target for glioma treatment,due to its role in controlling the migration and invasion of glioma cells and its angiogenesis.[1]
Regulation
PAXIP1-DT can controll the migration and invasion of glioma cells and its angiogenesis.[1]
Expression
LncRNA PAXIP1-DT could upregulate the KIF14 promoter activity by recruiting transcription factor ETS1.Overexpression of lncRNA PAXIP1-DT enhanced migration, invasion,and angiogenesis of human umbilical vein endothelial cells in glioma by recruiting the transcription factor ETS1 to upregulate the expression of KIF14.[1]
Diseases
Gliomas[1]
Labs working on this lncRNA
- Department of Oncological Neurosurgery, First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, 130021, Jilin Province, People's Republic of China.[1]
- Qingyuan People's Hospital, The Sixth Affiliated Hospital of Guangzhou Medical University, B24 Yinquan South Road, Qingyuan, 511518, Guang dong Province, People's Republic of China.[1]
- Department of Pathophysiology, Jilin Medical University, No. 5, Jilin Street, Jilin, 132013, Jilin Province, People's Republic of China.[1]
- Department of Neurovascular, First Hospital of Jilin University, Changchun, 130021, People's Republic of China.[1]
- Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, 130033, People's Republic of China.[1]
- Department of Oncological Neurosurgery, First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, 130021, Jilin Province, People's Republic of China. anglitangjing@126.com.[1]
- Qingyuan People's Hospital, The Sixth Affiliated Hospital of Guangzhou Medical University, B24 Yinquan South Road, Qingyuan, 511518, Guang dong Province, People's Republic of China. qilingip@126.com.[1]
- Department of Pathophysiology, Jilin Medical University, No. 5, Jilin Street, Jilin, 132013, Jilin Province, People's Republic of China. qilingip@126.com.[1]
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Xu H, Zhao G, Zhang Y, Jiang H, Wang W, Zhao D, Yu H, Qi L. Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression. J Exp Clin Cancer Res. 2019 Dec 10;38(1):486. doi: 10.1186/s13046-019-1474-7.
