Difference between revisions of "CHROMR"
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Approved name:cholesterol induced regulator of metabolism RNA | Approved name:cholesterol induced regulator of metabolism RNA | ||
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==References== | ==References== | ||
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| − | <ref name="ref1">Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3.</ | + | <ref name="ref1">Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3.</ref1> |
</references> | </references> | ||
Latest revision as of 10:32, 19 February 2021
A primate-specific lncRNA ( CHROME ), elevated in the plasma and atherosclerotic plaques of individuals with coronary artery disease, that regulates cellular and systemic cholesterol homeostasis.
Contents
Annotated Information
Name
Approved symbol:CHROMR
Approved name:cholesterol induced regulator of metabolism RNA
HGNC ID:54059
Previous name:PRKRA antisense RNA 1
Alias symbol:CHROME
prev_symbol:PRKRA-AS1
RefSeq ID:NR_110204
prev_symbol:PRKRA-AS1
Characteristics
A primate-specific lncRNA, increased in the setting of human atherosclerotic vascular disease, that contributes to the maintenance of cholesterol homeostasis.
Function
CHROME as a central component of the non-coding RNA circuitry controlling cholesterol homeostasis in humans.<ref name="ref1">.
Regulation
CHROME promotes cholesterol efflux and HDL biogenesis by curbing the actions of a set of functionally related microRNAs that repress genes in those pathways<ref name="ref1">.
Expression
LncRNA CHROME expression is influenced by dietary and cellular cholesterol via the sterol-activated liver X receptor transcription factors, which control genes mediating responses to cholesterol overload.<ref name="ref1">.
Disease
- systemic cholesterol homeostasis<ref name="ref1">.
Labs working on this lncRNA
- Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA<ref name="ref1">.
- Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands<ref name="ref1">.
- Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, USA<ref name="ref1">.
- Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden<ref name="ref1">.
- Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany<ref name="ref1">.
- Max Planck Institute for Molecular Genetics, Berlin, Germany<ref name="ref1">.
- Department of Microbiology, New York University School of Medicine, New York, New York, USA<ref name="ref1">.
- INSERM U1111, Centre International de Recherche en Infectiologie, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France<ref name="ref1">.
- Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA<ref name="ref1">.
- Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA<ref name="ref1">.
- Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University Ithaca, New York, USA<ref name="ref1">.
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany<ref name="ref1">.
<ref name="ref1">.
