Difference between revisions of "PXN-AS1"
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PXN-AS1-L interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.<ref name="ref1" /> | PXN-AS1-L interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.<ref name="ref1" /> | ||
===Expression=== | ===Expression=== | ||
| − | [[File: PXN-AS1. | + | [[File: PXN-AS1-exp.png|thumb|550px|Overexpression of PXN‐AS1-L promotes nasopharyngeal carcinoma cell proliferation, migration, and invasion.<ref name="ref1"/>]] |
PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.<ref name="ref1" /> | PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.<ref name="ref1" /> | ||
Revision as of 04:19, 22 February 2021
LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Contents
Annotated Information
Name
Approved symbol:PXN-AS1
Approved name:PXN antisense RNA 1
HGNC ID:44123
Previous name:PXN antisense RNA 1 (non-protein coding)
Alias symbol:EyeLinc4
RefSeq ID:NR_038924
LncBook ID:HSALNG0094500
Characteristics
PXN-AS1-L is upregulated in NPC tissues and cell lines.[1]
Function
PXN-AS1-L interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.[1]
Expression
PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.[1]
Regulation
LncRNA PXN-AS1-L is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Diseases
Nasopharyngeal carcinoma (NPC) malignancy[1]
Labs working on this lncRNA
- Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
- Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
