Difference between revisions of "PXN-AS1"
(→Expression) |
|||
| Line 16: | Line 16: | ||
LncBook ID:HSALNG0094500 | LncBook ID:HSALNG0094500 | ||
===Characteristics=== | ===Characteristics=== | ||
| − | PXN-AS1 | + | PXN-AS1 is upregulated in NPC tissues and cell lines.<ref name="ref1" /> |
===Function=== | ===Function=== | ||
| − | PXN-AS1 | + | PXN-AS1 interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.<ref name="ref1" /> |
===Expression=== | ===Expression=== | ||
| − | [[File: PXN-AS1-exp.png|thumb|550px|Overexpression of PXN‐AS1 | + | [[File: PXN-AS1-exp.png|thumb|550px|Overexpression of PXN‐AS1 promotes nasopharyngeal carcinoma cell proliferation, migration, and invasion.<ref name="ref1"/>]] |
| − | PXN-AS1 | + | PXN-AS1 overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1 silencing suppresses NPC cell proliferation, migration, and invasion in vitro.<ref name="ref1" /> |
===Regulation=== | ===Regulation=== | ||
| − | LncRNA PXN-AS1 | + | LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.<ref name="ref1" /> |
===Diseases=== | ===Diseases=== | ||
Nasopharyngeal carcinoma (NPC) malignancy<ref name="ref1" /> | Nasopharyngeal carcinoma (NPC) malignancy<ref name="ref1" /> | ||
Latest revision as of 04:22, 22 February 2021
LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Contents
Annotated Information
Name
Approved symbol:PXN-AS1
Approved name:PXN antisense RNA 1
HGNC ID:44123
Previous name:PXN antisense RNA 1 (non-protein coding)
Alias symbol:EyeLinc4
RefSeq ID:NR_038924
LncBook ID:HSALNG0094500
Characteristics
PXN-AS1 is upregulated in NPC tissues and cell lines.[1]
Function
PXN-AS1 interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.[1]
Expression
PXN-AS1 overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1 silencing suppresses NPC cell proliferation, migration, and invasion in vitro.[1]
Regulation
LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Diseases
Nasopharyngeal carcinoma (NPC) malignancy[1]
Labs working on this lncRNA
- Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
- Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
