NONHSAT015489

Please input one-sentence summary here.

Annotated Information

Transcriptomic Nomeclature

Please input transcriptomic nomeclature information here.

Function

Please input function information here.

Regulation

Please input regulation information here.

Expression

Please input expression information here.

Allelic Information and Variation

Please input allelic information and variation information here.

Evolution

Please input evolution information here.

You can also add sub-section(s) at will.

Labs working on this lncRNA

Please input related labs here.

References

Please input cited references here.

Basic Information

Transcript ID	NONHSAT015489
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	1554 nt
Genomic location	chr10-:90751179..90752732
Exon number	1
Exons	90751179..90752732
Genome context
Sequence	000001 TTCCAAGTAA TTAGCACTTT GCATCTATTT TATTTATTGC TACTACTAAG AAAACATAAC CGTGAAGGCA TAAAAGCAAA 000080 000081 CATTTTCTGT AGACACATGA GGTGACACAA GAGTGTTGAA ACTTCTTTAA GGATAAAGGC CTGATGTTAG GCATGTCGTG 000160 000161 AGCGCAAAAC CAATTTCTGT GTAACTAAAT TTAAAAGAGT CATATTAGAG GGGAGAAATG GAAGATAAAC TGCAAAACGT 000240 000241 AAACAATGAT TACTTAGGTG ATAGAGTTAT GTCTGATCTT TGTATTTGAC TCATCTGCAT TTATAAATTT TATTTAATAA 000320 000321 GCCTTAATTT CCTAGGCCAT ATATCATATA CAAATATAAG TTATACCTAA CTTATAGGTA TTATAATATG TATATATACA 000400 000401 TAAATGTATG AATATTTACA TATGCGTGTG TGTGTGTATT CTTTCAGAAA AGCAAAGTTT TCTTCGGGCT TTAAACACGC 000480 000481 AGCCTCTGGT AAAGGTGCTA TTGGTACAAA AGTTCAACAA GCATAGCTCC AAGCTTTGAC AATTTTCTTA CACTTTACTA 000560 000561 ATACTGCTGT CCAAAAACTA TGAGATTTTC AAAGCAGCCA ACATTGCAGT GGTGCAATGG TTAATAACAA GAGAGAGAAG 000640 000641 AGTGTGGCCT GAGGTTGTAT AAATGTTTTC TCAATCTTGA ATCATTAATT TTCTCCAAGG AAGTTTCTAA AGAATCCCAA 000720 000721 ATAGTGCACA CTATTTCTGA AAGGAACAGG ATTTTTTTTT CTAATCATAA AATGGACCCA GACATCTCAG CCTCTTGGTG 000800 000801 TAATCTGGAT ATCAGATGCA ATCAGCGAAC AGCCTGAGTT TTGGAATTAG ATCTGAGTTC AATCCCATAT CTCCCATTTA 000880 000881 CTAGCTGTGT GATCTTGGCT GAATTACTGA AGCTCTCTGA ACCTCATTTC GCCATCTGTA AAATGGGGAT GTGGTTATCT 000960 000961 TCCCCACTAC ATGGCTCTCG TGAGAATCCG CGGAGATCAC ATTTGTAAAC ACTTCTCTCG CTATGCCTGG CACTTTGTTG 001040 001041 GGGCCCAATA AAATAAAAAT CCATGGACTC TCAGAGGCTC CGGTACTCAA ATGAGCCTCC TGGATCCACG TCTCTTTGAT 001120 001121 TAGCCATCTG CAAGCTGGCA TTTCTGAGCG AGGGACTTTT CAAAACAGGC TGCTCAAGTT TCTTGGCCAA TAATAGGCGC 001200 001201 CGGGTTCTGT GCGGTGGGAA CGAGTACCAC CAACCCCAGC AGGAGACCAA GCAGAAATCA CCATGGGAGT GCAAGCTAAG 001280 001281 AAAGGGCAAA AGAAGAAAGA GAAGGGCAGA AAAACAAAAC AAAATGAAAC CACTCAGGCA GCGACTTACA GTCTTAAAGA 001360 001361 GAGAATTCCC GGAAGGGAGA CAAGGCAGTT TCTTTTTCTG TGTGACAATA AAAAACGGTA AACAAGCCTC CAGAAGCTCA 001440 001441 TTCAGCCCCC ATATAACTTT TTCGAGAAAG AAAAGGTGCC GTTCTTCCGA GCCCTCCGGC TTAACCACTG CTTCGGTGCT 001520 001521 GACTTATTTC CTACGTCTGA GAACTGCCAG AAAA

[back to top]

Annotation (From lncRNAdb)

[NONHSAT015489]

Section	Description
ID	SAF
Characteristics	1556 bases; transcribed from the opposite strand of intron 1 of the human Fas gene.
Expression	Detected in several human tissues (such as heart, placenta, liver, muscle and pancreas, as well as kidney in lower levels). It was also detected in different cancer cell lines, including Jurkat (acute T-cell leukemia), MES-SA (uterine carcinoma) and U-937 (Histocytic Lymphoma); moderately expressed in CA46 (Burkitt°Øs lym- phoma), Raji (Burkitt°Øs lymphoma) and only slightly expressed in MG-63 (osteosarcoma).
Function	In vitro over-expression of Saf protects cells from Fas-mediated apoptosis. Over-expression of Saf induces alternative splicing of FAS transcripts, wherein an alternative exon overlapped by the antisense RNA is retained and non-adjacent 3' exons are skipped. This results in Fas proteins that are not able to anchor to the cell membrane, therefore regulating Fas-mediated but not TNF-alpha-mediated apoptosis.
Conservation	Saf gene appears to be conserved among the primates and is absent in the rodents.

[back to top]