Lnc-LRR1-1:1

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Annotated Information

Name

7SL

Characteristics

~300 nt, transcribed by RNAPIII.

The eukaryotic small cytoplasmic 7SL is an RNA component of the SRP (signal recognition particle), which associates with the ribosome and targets nascent proteins to the endoplasmic reticulum for secretion or membrane insertion ((Walter 1982)) ((Zwieb 2004)).

Function

7SL RNA is required for structural and functional properties of SRP ((Walter 1982)), being a scaffold component upon which the six proteins of the SRP bind in higher eukaryotes. In mammals SRP consists of the SRP RNA the six proteins named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 ((Walter 1983)).

Bacterial SRP has a much reduced complexity, consisting of a small SRP RNA (4.5S RNA) and a homolog of protein SRP54, also called Ffh or P48 ((Bernstein 1993)). In archaea only two SRP proteins, SRP19 and SRP54, are thought to be part of the SRP, although SRP RNA closely resembles the mammalian homolog ((Bhuiyan 2000)).

There is evidence that a highly conserved region of 7SL RNA catalyses the binding of SRP to its receptor SR, and that this RNA stimulates the GTPase activities of the SRP-SR complex ((Zhang 2008)) ((Siu 2006)) ((Peluso 2000)).

Expression

Ubiquitously expressed at high levels. Localises to the cytoplasm. An expression profile from 11 human tissues using RNA sequencing showed 7SL was most highly expressed ncRNA and could be an order of magnitude more highly expressed than any mRNA ((Castle 2010)).

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	lnc-LRR1-1:1
Source	LNCipedia2.1
Same with	,
Classification	intergenic
Length	299 nt
Genomic location	chr14+:50053297..50053596
Exon number	1
Exons	50053297..50053596
Genome context
Sequence	000001 GCCGGGCGCG GTGGCGCGTG CCTGTAGTCC CAGCTACTCG GGAGGCTGAG GCTGGAGGAT CGCTTGAGTC CAGGAGTTCT 000080 000081 GGGCTGTAGT GCGCTATGCC GATCGGGTGT CCGCACTAAG TTCGGCATCA ATATGGTGAC CTCCCGGGAG CGGGGGACCA 000160 000161 CCAGGTTGCC TAAGGAGGGG TGAACCGGCC CAGGTCGGAA ACGGAGCAGG TCAAAACTCC CGTGCTGATC AGTAGTGGGA 000240 000241 TCGCGCCTGT GAATAGCCAC TGCACTCCAG CCTGGGCAAC ATAGCGAGAC CCCGTCTCT

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Annotation (From lncRNAdb)

[lnc-LRR1-1:1]

Section	Description
ID	7SL
Characteristics	~300 nt, transcribed by RNAPIII. The eukaryotic small cytoplasmic 7SL is an RNA component of the SRP (signal recognition particle), which associates with the ribosome and targets nascent proteins to the endoplasmic reticulum for secretion or membrane insertion (Walter (1982)) (Zwieb (2005)).
Expression	Ubiquitously expressed at high levels. Localises to the cytoplasm. An expression profile from 11 human tissues using RNA sequencing showed 7SL was most highly expressed ncRNA and could be an order of magnitude more highly expressed than any mRNA (Castle (2010)).
Function	7SL RNA is required for structural and functional properties of SRP (Walter (1982)), being a scaffold component upon which the six proteins of the SRP bind in higher eukaryotes. In mammals SRP consists of the SRP RNA the six proteins named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 (Walter (1983)). Bacterial SRP has a much reduced complexity, consisting of a small SRP RNA (4.5S RNA) and a homolog of protein SRP54, also called Ffh or P48 (Bernstein (1993)). In archaea only two SRP proteins, SRP19 and SRP54, are thought to be part of the SRP, although SRP RNA closely resembles the mammalian homolog (Bhuiyan (2000)). There is evidence that a highly conserved region of 7SL RNA catalyses the binding of SRP to its receptor SR, and that this RNA stimulates the GTPase activities of the SRP-SR complex (Zhang (2008)) (Siu (2007)) (Peluso (2000)).
Conservation	May have originated from the bacterial SRP (GTP-regulated ribonucleoprotein that targets secretory or membrane proteins during translation), it is ubiquitously present in eukaryotic cells and several viruses (Li (1982)). The secondary structure of 7SL RNA is conserved from prokaryotes to distant eukaryotic species (Labuda (1994)).
Misc	7SL is the RNA ancestor of Alu transposon sequences, which emerged ~ 55 million years ago, are present specifically in primates and comprise ~10% of the human genome. Rodent B1 elements, as well as 4.5S and primate BC200 RNAs are also related to the terminal portions of 7SL RNA sequence (Labuda (1994)) (Quentin (1994)).
Name	RN7SL1: RNA, 7SL, cytoplasmic 1

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