NONHSAT017524

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Annotated Information

Name

Kcnq1ot1: Kcnq1 opposite transcript 1,LIT1: long QT intronic transcript 1

Characteristics

91 kb, unspliced; imprinted (paternally expressed), it is transcribed from intron 10 of the maternally expressed Kncq1 (KvLQT1) gene from a CpG island that is the imprinting control region (IC2) ((Smilinich 1999)). This imprinted region contains at least eight genes that are expressed exclusively or preferentially from the maternal allele ((Kanduri 2011)).

Function

PSummary: Kcnq1ot1 has a role in the organization of a tissue/lineage-specific nuclear domain involved in epigenetic silencing of the Kcnq1 imprinting control region.
Genes imprinted by kcnq1ot1 include Kcnq1, Cdkn1c, Slc22a18 and Phlda2, which are ubiquitously imprinted and Cd81, Osbpl5, Tssc4, Tspan32 and Ascl2, which are only imprinted in placenta (reviewed in (Kanduri 2011). An expansion of the Kncq1ot1 imprinted domain to include splice variants of Th and Ins2 was recently described ((Jones 2011)).
Kcnq1ot1 silences genes by coating chromatin and recruiting repressive chromatin remodeling complexes such as G9a, PRC1 and PRC2 ((Terranova 2008), (Pandey 2008), (Umlauf 2004), (Zhao 2010)) .
Kcnq1ot1 transcript has a modular structure, the silencing element (that mediates the epigenetic silencing and directs the imprinted locus to a heterochromatin environment in the perinucleolar region) appears to be a short <1kb conserved sequence near the 5' of the transcript ((Mohammad 2008)).
Kcnq1ot1 forms a silenced subdomain ((Terranova 2008))((Redrup 2009)) commonly localised to the perinucleolar region during S phase ((Mohammad 2008)). The silenced subdomain may be important to the maintenance of transcriptional repression.
Kcnq1ot1 interacts with Dnmt1 and recruits it to somatically acquired differentially methylated regions (DMRs) of imprinted genes ((Mohammad 2010)).
In vivo knockout study shows that paternal inheritance of a deletion encompassing an 890-bp (Delta890) silencing domain downstream of the Kcnq1ot1 promoter leads reduced interaction with DNMT1 and to selective incomplete relaxation of the imprinting of imprinted genes in a tissue-specific manner ((Mohammad 2010)).
Delta890 showed altered DNA methylation at somatically acquired DMRs but not in histone modifications of the ubiquitously imprinted genes. Thus, it has been proposed that the ubiquitous and placental-specific imprinting of genes within the Kcnq1 domain might be mediated by distinct mechanisms, and Kcnq1ot1 RNA might mediate the silencing of ubiquitously imprinted genes by maintaining allele-specific methylation through its interactions with Dnmt1 ((Mohammad 2010)).

Expression

Nuclear localised.
Expressed in most human tissues.
Mouse RNA found to be highly unstable with a half-life <2 hr in N2A (neuroblastoma) cells ((Clark 2012)).

Conservation

Patches of highly conserved repeats in 5' side of transcript, which contains the silencing domain ((Mohammad 2008)). Promoter control elements are highly conserved between mouse and humans, including CCAAT elements that are targets of NF-Y regulation ((Pandey 2004)), as well as the position of CpG islands in the imprinting control region ((Paulsen 2004)).

Misc

(Syndromes and diseases associated, eg Beckwith-Wiedemann syndrom, and cancers (see references list):
Associated with multiple balanced chromosomal rearrangements in Beckwith-Wiedemann syndrome (BWS) and an additional break-point in embryonal rhabdoid tumours; in particular, aberrant methylation of the CpG island associated with Kcnq1ot1 promoter is strongly associated with cancer risk and specific birth defects in BWS ((Smilinich 1999))).
For review on Kcnq1ot1 mechanism of action see ((Kanduri 2011)).

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT017524
Source	NONCODE4.0
Same with	,
Classification	antisense
Length	59461 nt
Genomic location	chr11-:2661768..2721228
Exon number	1
Exons	2661768..2721228
Genome context
Sequence	000001 AGGCAGAACG GTCGCCGCGT CGCCTCAGCA CGGACCTCCA GGGAGCTCCT CAGCAAGATC CTGCCAGGGC GCCCCTCAGC 000080 000081 GCGATTCTGC CGGGGTGCCT CTCAGCGTGG TCCTCCCCGG GGCTCCTCAG CACGATTCTC CCGGTGCGCC CCTCAGCGCG 000160 000161 GTCCTCCTCG GTGCGTCAGT CATCGTGGTT CTCCCCGGCG CGCCCCTCGG CGCGGTTCTC CTCGGGGCTC CTCAGCGCGG 000240 000241 CGCTCTTCTG GGGGCTCCTC GGCGCAGTTC TCCCCGGGGA CTCCTCGGCG CCGTTCTCCT CGGGGCACCC GGGGCTTTTC 000320 000321 GGCGCGGTTC TCCCCGGGGG TTCTTCGGCG CGGTTGTCCC CGGGGGTTCT TCGGCGCGGT TCTCTCCGGG GGCCTCTCGC 000400 000401 CGCGGTTCTG TTCTCCCCGG GGGCTCCTCA GCATGGTTCT CCTCCGCGCG GTCCTCCCTG GGCCTCCTCA GCGCGGCACT 000480 000481 CTCCTGGGGG CTCCTCAGCG CGGCACTCTC CCCGGGGGCT CCTCAGCGCG GCACTCTCCC GGCGGCTCCT CAGTGCGGTT 000560 000561 CTCCCAGACT CTCCTCAGCG CGGCCCTCCC CATCTCTCTG GGAGGGTTTG AACACGGTCA GCACGGACCT GGGCGGACGG 000640 000641 CGCGGGACGG GTGATCACTG GCGTTGCTGA GGTGAGCTGT GTGCCCCGCG GCCGTCCCAG ATCACAGGCG TCAGCAGTGC 000720 000721 AGCCTGGCCT GGGCAGTGCG CTCCCATCTG CACCTTATGG ACAGCGTGGC CAGGGTCGAG GTCCGAGTTC CTGGCCGCGT 000800 000801 CCCAAGGATC GGATTCCGGG TCTATAGTTC TCATGGTGGT TCAGAGTGGG CTGAATTGGG ATTGGAGTCT GGAATCCGCA 000880 000881 TCGTGGTTCT GAGTCCGCGC TATTGGGATG GAAGTTGGGA ATCCATGTTG TGGTTTTGAG TCAAAGCCCG AATTGGGACC 000960 000961 GGAGTCGGAA ATCCACTTAG TGGTTCTGAG TCAGGGCCCG AATTAGGATC GGAGGTGGGA ATCCCCGTTG TGGTTCTGAG 001040 001041 TTAGGTATCC TAGTTGGGAT CAGAATTCGG GTCTAGGGTC CACATCCTGG CTGGGAGTTT GCCTGAGTTG GGATCTGAGT 001120 001121 AGTTGGGGTC CCAGTCAGTC CGGGTCTGGA GTCCGCATGG TGGTTTTAGG TAGGGCCTCA TTAGGGACAG AGGATCGGGA 001200 001201 GTCTGAGTTG GGGACCTGAA TCCCGGTCTG GAGTCTGCAT CATGGCTCTG AGTTGAGATC CAAGGGAGGT CCGAGTTGGC 001280 001281 GACTGGAGTC AGGGTCTGGA GTCTGTCTTT GGGTAGAGGT TCTGAATGGG GGGCTCTGAG TTAAGAGATT GGGATTGGGG 001360 001361 TTAGAGGTCT CAGTGGGGTA TGGGAGTCAG GAATTGAAGT CGAAGTTCTG CCTCTAGGTG GGGATTCTGA GTCAGGAATT 001440 001441 AGGGGGCGAA GTAAAGGTTG CAGTCTGAGT TGGGGGTGGT GATCACCTGC CAGGTGAGAG GTAGTGGTAG AAGTCTCTTG 001520 001521 GTCATATTGG AGATGAGAGT TGATCAGATG CAGGTCTCAG TCTGGGTAGT AGGCTTGAAG GGCCACCACT ATGTTCAGAT 001600 001601 CCCAGTACCC CACTGTGGTC CCTGAGCAGG TCAAATAGCC TTTTATATAA AATTGAGAGT AAGAGTGCCT TCCCACAGCA 001680 001681 CTGTTCTGGT TATGAAAGAG AATAATTCAT CCAGGTAGAA TAGTTCTGTC TTAGATTATC ACAAAGTATA AAAACTTTCC 001760 001761 TGATAATATC CACATTTGAT GTGCATTTAC CAGTTCTTTC TTTACTGTGG TGCCCCTTTT GCTAGACCAA AAGCTCCCAA 001840 001841 CGAGGAACTC TGTTTTGTTT TCTGCTGCCT GCTCTGTACC CAGCCAAGAG CCTGATACAC AGCCTTACTC AGTCAGTACT 001920 001921 TGAAGGAAAG CAGGCAGGCA GGATTAACCA GATTTCTATG GTGTCTCAAA TGATCCATTT CTGCACCTGT TTTCCAGATA 002000 002001 CTCAGTAGGA GAAAAATTTA AGGATTGAGT TGCTTGATTA TGGGTGTATT TTAATGTGTT TCCTAACATG CTGAGGAGAA 002080 002081 AAGTGGGTCT GTTTCAGGAT TTATGCTCCA GCTAGAGGGA TTTTTTAAAA TTGCGAATCA GAGCATGTCC AAATTCAGAT 002160 002161 AGAAAGCACA AGAAAACTAT AAAGAATTTC CCTTATGAAT GTAGATGCAG AAGTTCCTTG TACAATGCTA GCTAACTGAA 002240 002241 TCCAATAATA TGTATTAAAC AACAATTCTT AAACAAGTGG GATTGCTCTT AGGAATGCAA AGATGATCCA ATATCAGAAA 002320 002321 CTTTATCCAT GTAATTCACA TTAAGAGGCT ACAGGAGAAA AACCATATGG TTCCCTCAAT AGAGGCAGAA AAAAATGATG 002400 002401 TGATAAAGTT TAACGCCTAT GTGTGATTTT GGGGTAGTGG AGTACACCAC TTAGCAAGCC AGGACTAGAG AGGAACTTCT 002480 002481 TCAACTTGAT ACAAGTTATA AACCAAAACT TAACTTTTCA GTAAACTTGA TAGAGAAATT AAAAGTGTAT CATTCTCTTT 002560 002561 AAGATAAGGA GTAGGCCAAG GATGTCATCC TGGCCATACC CTAATACAAG AAAAAGAAAT GGGGATGTGA GGATCAGGTA 002640 002641 GGAAGTGATA AAACTTAGTG TAGCTCATAG GGTTGATGGT CTCCATAAAG ATTCTCAAAC ATTTTGGTGT TACGACTTGT 002720 002721 TGTATTCTTA AAAGTTATTG AAACCCCCAA AGGGCTTTTC TTGATAGAGA TTCTATCTGT TGATAGTTAC CATCTTAGAA 002800 002801 GTTAAAACTA AGAAATGTTT AAAGCAGAAC TATACAAGCA CATATTCCAC TGGGGTCATG GTGTGCTGCC TCTGGAAAAC 002880 002881 TCTTTATCTT TGTGAGAATG AAAGAAAAGG CAAATAATGT CGAGTATTAT TATGAAAATG TTTTTGACCT TTCCTGAAAG 002960 002961 GGTCTGGGGG GCTCTCTGGA ATCCCCAGAC TACACTTTGA AAATTACTGG GCTACATGGA AAAAAAAAAT TAAGGAACTT 003040 003041 AACAACTAAA GAGAGATTTC AGATTTCAGA GAGGTTTTGG ATATAAGATC AGTGTACTCA AAACAAAAAA CAAAAACAAA 003120 003121 CCACATTTCT TTATGCCAAT AGCAACTGAC TAAAAAAAAG CATAATAGAG ATTAGGACAG CAATCAGAAT AGCAGCAAAA 003200 003201 TTTATACCAG TCTAGGAATT AACAAAGACG ACGACTTTTA TGGAAAAAAT TTTAAAACTC TATTGGAGGA TATAGAGGGA 003280 003281 GATCTTTCCA TATGCAGAGA CATTTTATTT TCTTGAACAG GGCAACTTGG CATTAGAATG ACGTCAGGAT TTTCCAAATC 003360 003361 TGTTAAGTTC AACAGGACTC CACTCAAACT TCCAGTTGGA GGGCTTGAGT AATTTAACAA ACATATTCTA AAATGTATGT 003440 003441 GGAAGAAAAA TATTTGTAAA TGCCAACTGA ACTTTTGAAA AGGAGAGCAG AGGACTTCTG CTGGCAGATA CCAGGGCACA 003520 003521 CGCCAACTTC AGCAATCAGA GCGGTGTGGT GACAGAGGCC CAGAAGAGAG CTCAGAGGTA ACTCCAAGTC TAGAGGAAGG 003600 003601 GGACATGTGA TAAAGGTGGC ACCACATATC AGTGGGGACT GTTCAGAAGA TGATGTTGGA AAGCCAGCCC TAAAATGGAG 003680 003681 GAATAGGAAT ATGGATTCCT AACTGAGCCC CTAGGAAAAG TAGACTCCAA ATGGACTAAA TATTTGAAAG CAAAAGGTAG 003760 003761 TTGCCATTTG TTTAATAGGA GAAAAAATGA ATAATCTCCA GGGCCAGGGT GGCCGTGGGG TTCTTAAACA GGATCCAGAA 003840 003841 AGCACAAACC TCAAGACTAA AATGTATGAA CTTGAATGCA TTAATGATTA TGGATTAAGG ATTTCTGTTA AATAAATCCA 003920 003921 TCATGGCAAG GGTCAAGACT GTTTTCATAA TAATACTAAG GAAACAATTT GCGTTTTTCA CTTTTACACT CATGAATGTA 004000 004001 ACTTTGCCAT GACTCATTAC AAGATATTTG AAACAATTAA AGCTGAGGAG GGAACAACAG CTAAAATATA CCAGAAAGCA 004080 004081 CCACAAATCA TTAAGAAAAA GGTAGGAAGA TTGCCAGTTT GCAGGAGGGT TAACAAACAG ATGAAAATTT GCCCAAGCTA 004160 004161 ATCAGTTATC AGAGAAATGT AAATGAAAGC AACAGCTATT CTTCATAGGA GAAGCATTAG AAAGTAGGAT AAGGCCAAGT 004240 004241 GTTGGCAGAA GGCAAGGAAC AAGCCTCCCT GTGTGCTGCA GGTGGGGACG GAGACAGGCA CAGACGTTCT GAAGAGCTGG 004320 004321 CCAACACTTC TTCCTCAAAT AAAATATTTT ATACCTGTGG CCCAGCAGTT TCCCTCCTAA GTAAACATGC TGGAGCAGTT 004400 004401 CTCACCCAGA ACAACGAGAG GCTGTGTGTG TGCATGCTCA GGGCAGCATG GCCCATAGGG GTGGGCAGTT GGAGCTGGTC 004480 004481 ACTGTGGTTA GGAGCAGGGG ACTAGATGTA CACTTCACAA GATAGAGACG CGTGGAAACA CAGTGCTGAG TGACACAAAT 004560 004561 GCCAAACAGA AAGAGGGCCT CAGTACATGA CTGTGTATTT AAATTAAAAT TACACACCAC CCAGACACGC AGTACTAGGG 004640 004641 AGTGCTCGTG AGTGCACACA CACACACACA ATGATATAAA TAAATTACCC TGGAGAAGCT GTTTGTGTAG GGAGGAGAGC 004720 004721 AAGGATAGAG GCTAGAGATG AAGTGGAAAA GCATGGAGAG GAAGAGAGCG GTGACTTTAT GCAGACCCTT ACAGGGTGAC 004800 004801 AGTGTTTCAT AGGCTGAGGG CTGTGATCAA CTCTGTGCAG AGTCCCAAAA GCCAAGAACC AACGAATGAA TGTGCCTCCA 004880 004881 TGACTCTCCT GCCAGATACC CTCTAGTGGC TTCTATTTCT AGGAAATAAA ATTCAAATTC CATCAGGTTT TTACAAGATC 004960 004961 TGCCCTGCTT ACCTCTCTGA CCACTGTCCT CCCTCACTGA GCTTTGGCTC TGCCAGCCTT CTTCTTCTTT GTTAAATCTG 005040 005041 CCAAGTATCC CTCCTGCCCC AAGGCCTTCA CCACCTCTGC CTGGCTTGTC TTTTCTGGTG ATCTTCCCTT GACAATTCCT 005120 005121 TCTTCTTATT TAAATCTCAC AGGAAATTTT GCTCTGACCT GCCATATCTG TCATCCCCTT CAGTCACTCA CTAGCTGACG 005200 005201 ACTACCTTTC GAGTCTCTGC AAAGCACAGG CTACGCTTTT CTAGTTCCTT AGACATCTAC TTATTTGTTG GCTGCCTATC 005280 005281 TCTTCCACCG GAAGAGAGGC CCCAAGAGAG CATATCTGTC TTCCGTATAG GGTCCGCACA TGGTGGGTGT GTCACAGATT 005360 005361 TCTGTTGAAT GGTTTCATTC ATTTATTGAA CGAAGGAAGA GGCCAGGCCA GGAAAGTGTG CCTCCATTTT CACAACTCAG 005440 005441 TGAGAAAGCA AATAGCATGT CAAAATCTGA CCCCTTGCAA CCAGGGTTTC TTAGCCAGCC ACACTGGTAA TGCTTGGGAC 005520 005521 AGGATGTATC TTTGTTGTGA GGGGCTGTCA TTTATATTGT AAGATGTTTA GCACCCTGCC TGGTCTCTAC CTAGTTGATA 005600 005601 TTAGTAATTC TCCCATAGTC ATGATAGCCA AAAATATCTC CAGACATTGC CATATGTCCC CTGGGGGGCA CCGCAGATGA 005680 005681 CAACCACTTC CTTAGAACAG CTCTTGGGAC TGGGATGGTG TCTCTGCTGT GGCTCTTTAA AGGCAGCAGG CCCTGGCTTG 005760 005761 CATCCTGCCA CATCTAACAC CTATAGCCTC ACCACCTCGG TGAGAAAGAC CCTGGCCCAG GCCTGGCCAA TCAGAGTACC 005840 005841 CTCTTCCCTG GTCAGCAGTA TAATTTGTTT GGCAAGCACT TCCAGTCCCA CAACCTATGG GCTGCCACCC AGAGGTTTAG 005920 005921 TTGGAACTAC GTGTCAGCTG CCGTCCCTCA GCCATCTATG GCATGGGCAC CTGTGGCTTG ACCAAGTTGG AGGTGGCCTA 006000 006001 GAGAGGCCGG GCTGGGCCTG CTCACCTTCT CCAGTTAGTG CAGACTGATG AATGAGTGGT TCTCAGCGGA TACCGGATCC 006080 006081 AGGTTTGCAG TACACTCCAG GAGGAGGACG AGTAGGGTTT CCCTCAGAGC AGGCCTGGAT GGGAGGGCAA GGGGTGGCCT 006160 006161 CTAATACTGC CTTTCCTTCC GGTGCCTTTA TCAGCCTGTG CCATGCTCCT CTGAACTGGC CGGCCCCAGC ATGTCCAGGT 006240 006241 TACTGGCAGG AGCCTGTATA ACCCAGGGTT CCAGTCACAC CAGCCAGGAA GGCCCATGAG GCTGGAGCGC ACCCAGTCTC 006320 006321 TGGCTGCTCT GTCTGCGGAA CTAAAAGCCT TTCTCCCAGA GCCTTTCCTA CGGCTGGGCG AAGCTCTTGT TTGCAATTTA 006400 006401 AATGTGGCCT CATTTATGGA AGAATCCCTG CTCCTCCGAA AAGCCTTGGG CTCAACCTCC CTAGCAGCCC GGGCCTCAGC 006480 006481 CAGGAGAAGA AATGGATCTA AAAGGCCTTT CTCCTGCTAA TTGTAGCAAT TAGCATTAGA GAATGGGGAC TCGATGGGGG 006560 006561 GCCAGCGCCT GGCAAAACAA GCTTATTCCC AGCTTAGGCC CAGGCCCAGC TCCACACACT GCTGCTTGGC CAGACTCGGC 006640 006641 CCCCACCCAG GGTCTGGTTG GCTTCAGGGC AGGGAGAGAG GGCCCAGGCC TGTGGGTGCT AAGAGCAGTT GTGGAGGGTG 006720 006721 TGCATCTGAG TTGTTAAGCC TGGTAGCTGT ACAGGTAGCC CTGGGCTATG ACTTGTGGTC CTCTCAGAAA AGGGTCTGAC 006800 006801 TGGAACGCAG AGCCAGACCA GATATTCATG AGTGGATCAC AGAGTGTAGA CTGAGGGCTA TCTGGTGATT GACAGAAAGT 006880 006881 AGTCTTGGGG CAAATGACTC TTAAAGAGTA AGGAGCCATT CCCCTCTATG GCTAACTGGA TGCCTTTCTC TCCCCCTGCT 006960 006961 CCAGAAAGGA CTTCCTGTTC CTTCACTGAG CGTGCTTGCT TATGAGGCTT CTGGAAACCA GGAGAGTTCA GTGGGCCTCA 007040 007041 TTATTGAGCG TATGGGCAGG ACAACCTGCT TGGGACATAG GCCATGCTAC AGTTGATTTT AGCCAGCTTG CTGCATCTAC 007120 007121 ACAGCACAGT GCCTTCCCAG GCAGTGAATT ATGTCTAACA GGCAGGGGAA TGATCATTGC CTCATGTTAG GGATGCAGTC 007200 007201 ATTCAAGAAA TATTTGTCAA ACACTCAGCA GGTACTAGAC CCTGGCCCAG AGGGAGGGAT TTGATAGGAG CAGGGACCTG 007280 007281 CCTACCCTCC CAGGGTTAGT GGACAAAGGG GAGAAAGACT AACTAATGTT GAAGGACCGT TTGCACCCTG AGGGGAGTGC 007360 007361 TGAGGCCTGG GAGCACAGCA GGTGTATAGC AGGAACCCAC TGGAACTAGC CTGGGGTCTG AAAAACTCCC TTGGGGAAAG 007440 007441 TGGCAGGGGC AGGCCAAGGG CCCTCTGGTG GTAGGGAGCC TGTGAGCACC TGGGATGGAA AGAAGCCAAG CATCTGAACT 007520 007521 ACCAGAAAGG CAGCTGCAGG ATTAAGCAAG ACCCACAGGT CTCTAAACTT TGAAAGGATG TCTGTCCACT GAGTAGATAA 007600 007601 TTGATTGGAA TGGGGCAGGG GATGTGAGAA TGCCAGTTAG GAGATGCCTG CAGTACAGAG AAATGGTGGC CTATCAGGAC 007680 007681 AGTGGCAATA GGGATGGAGG GAAGCAGGGA ACCTCTAGAA CTATGGATGG GTGAAGTAAG CCTGGCTTGG TGATGGGCTT 007760 007761 GAGGTGATGG GCAGGTGGTG AGGAAGCGGG TGTATCGGAA ATGACCCCAG AACTTCTGAC TTGTGCCACT GAAAGGATGG 007840 007841 GTGACACTGA AAGGACAGGG GCCTTCAGTA GAGTGGGCTA TAAAATGATG GAGGCTGTGG AGAGGAGGTG GGGGCAGGTG 007920 007921 ACTGGAATGT GGGTCTGGCT GGGTTGGAGA GACATTTGGG GGGTCAGGGC CTCACAGGTG GTCTGGAAGC CCTTGGTGCT 008000 008001 GAGGGAACAG CTTAGGGAAA TGGTTTGCAT AGAGAAAGGC ACTGGCATTT AGTGGCCATG CCAGAAGGGA AAACCTGCCA 008080 008081 AGGAGACTGA GGATAGAGCC AGAAAGATGG CAAGAAAGCC AGGAGAACTG GAGGGATGGA AAAGAGGACC TAGGGGTCAT 008160 008161 GGTCCTGGCA GAGGTCACAT TGGATCCAGT GCTTGTGATT CTCTGATTGC TGGCAGTGGA TGGCCACTGG CCTGCAAATG 008240 008241 GCCCTAGTGG AATGTCCCCT GCCTGTGTGG CTCCCTGTGG GCTGCCTCTC CCCTGGACAG ATGGGGAGAG ACCCCTTCCC 008320 008321 CACCTGGTTC TCTGTTTCAC CCTTGGAACT GTGGCGGTAA AGAGGACCTC CCCACAGTAC GTGCAGGGAA CAAGCTAGGT 008400 008401 TGACTCCCTC AGGGAGGCCT CGTCCTTGCT GAGGTATTTC ATAACCTCAG GATAGAGAAA TCCCCCCAAC TTTAATGCAA 008480 008481 AGCCAAGCAA GCTGAAAAAT GGCCTTGAAT AGGCTGAGAT GAAAAAACAA AGAGGCTGTC AACATCAGAG ACTCAGTGGG 008560 008561 GGCAGGGAGC TTCAGTGGAC TCCCCACAGA CAGCAGTTCC TGGGCTTCTA TGCCCAGACC CAGAGGCCTG AGCCCAAGAT 008640 008641 GTCAGGATGG GTGGTCACTG TAAGTGCAGT GGATTGTAGC TCAGGGGTGA GACATCGCCT TTTTCTTGTC AGCTCTCCTT 008720 008721 CCTGATTAGT GGCTCAAACA GCCTTCCGAG ACTCAAGGGG TTAACTGCAG ATCCTCTAAC TCCTCCACTT GCTAATTTTT 008800 008801 AAACACAGCT GAGCTCTGAG CACCCCTCCC AAGGCTGTGA GAGGCCAGAG GCCAGCACAG ACTCTGCACC AGGTCTGCAC 008880 008881 AGCCTCCACC CCTACTGTTG TCAGGAATCT GCAGGCATCT AGAACAAAGG TGCCTCCATT ATTTCCCTCA CCCAGCATAT 008960 008961 CCTGATACCT GAGCCAAGAG TTCACCCAGA GCTTTTGCCC ACTTCATTGA TGGTCTGGTG GGCTTTTGTT GACACATACC 009040 009041 CGTGACTCCC AAATGAACCT TTCAGGTTGG CTTAAAGCCG CTGGGACCTA CACATGACAA AACCCAGACG GAAACAGTGG 009120 009121 CTTACACTCC TGTGTCCCTA AAGGTACCTG TTCCTAACAG TGGGAGTGCC AGAGCCTGGA AGCTGGAAGC CAAGGAGACA 009200 009201 GGGACCTCCC TCCTGCTGAC CCCCTGCCAG GCCACATCCA CCTAAGGGAT TTGGGATCAT ACTCCATCTT CAACCACTGG 009280 009281 GATCAAATGG AAAGCCCTCA GGAATTCTGA GAGACAGCCC CTATACCTAT GTGCACTGAC ACACATACAC TGACAAATAC 009360 009361 GCATTCTGAC ACATATATGA ACATGCACAT ATGTGTGCCC CACTCCCTGC CAGGAGGTGG GTTCTGTCCC ATCTTTGACA 009440 009441 TGTTACTTCT TGTCCTTCCC TAGGCCCAGT GGCACTTTCT TTGTGATAGG TGCTGAGACC CCCCCGACTG GGCCCAGTGG 009520 009521 CTGTTCCCAG GACCCAGTCT CTGCTCTTAT CTTAACCCAG CTCTAGCTCC CAGGACCCCA GCCTTTCGCA GGGAGAGAGA 009600 009601 TAGCTCTTTT GGTCTGGCAC ATGTTCCATG CCAAGTAGTG GAAACAGCAG CTGCAGGGCA GCCTCAGACT TGACATCATT 009680 009681 TAATCCTTGT GACAATCCTA CAGGGAGGAA GACACTACAC ATATGTGCAG ATGCAGCAAG GAGCAGCTCA GCCACATGGA 009760 009761 ATGACTTGCT TGAGGTCACC AGGCACTTGA CACAGCAGAG TTTAGCCCAG TCTCTGGAGA GACCAGCCTT CCACATCCTG 009840 009841 TCATGCTGGG GAGGGCTGCC CGCTTTTTGT CCCTGCTCCC CCAGTTCTAA CCCCGGAAGA GCGATTGTCC CTGCTGTGCC 009920 009921 TTCAGCCCAG ACAGAAGCAG GCTAGGAGAG GGGAGGAGAG GCAGGGCTGG CCCTCGGAAG GCTCACCTTC CTCAACAGTT 010000 010001 CTCTGCTTGG GCAAAGGTCT TCCAAGCAGC CAGGCTCTGA GGCTAGTCAC TGTCATCGTT GGGTGAGGCA GCCTGGGAGT 010080 010081 ACCAGAAGTT GGAGCAGGTG GGAACCTTCC CCAGGGATGG GGCTGGATAG GCAGGGGTGG GTGCTAAGTG GCAGGCCACA 010160 010161 ACCAGGCACC TGGGAGGGCC AAGCACCACA CTGAGAACGC AGTGCTTCCC CTCCCCTCCT AGGCTGCTCA GGAACCCATC 010240 010241 AGTCTCCTGT AAACAAATGA GACTAAGTCT CTGGCACTCT AGGCCCAGGT GCAAAGGACA GCTGCCCCTG CAGCTACTCA 010320 010321 CTCTGCCCTG GCCCTCTCAG GAGGCTTGTG ACCTCTGCAC CTGCTGGCTT GTTTTGTTCC TAAAATACCC GGATCCTTGA 010400 010401 GAATCTAGAA GACACCACTG CTAACAGATT TCCACATCAT TCATTCTGTT CTTCCTGTGC AAGCTTCATG CTGGGACAGG 010480 010481 GACCATAAAA CAAGGTGACC CAAAACCTTC AGCAGAATGC AGGTAGGCAG AGCAGAGGTC TCTGGGAGTG TCATTCCAAG 010560 010561 GCAGTGTCTT CCTCCTCCCC TATGCTCCCC ATTTCCCAAG AGTGGGCTTC TTCCACCCCA CTCAAGCACC TCTTCCCAAG 010640 010641 GCTGACCTAA AGGCCTCAAG CTCTGCGGAT AGGGGCAGTC CTGAGGTGGC ATTGAGTCTT AGGGTTGGAG TGGGAGATAT 010720 010721 CTGTGCAAAG GCTGATAGGA ACGTCCTCCA AGGGCTGACT TCAAAGCTTG GCCTAAACCA CTGCATCAAA GTCAGCAAGC 010800 010801 TGAGCTGTTT GCACAGAAAA GGAGGAGGAG CAGGCCCTTG AGCCACCTGT AGCTCTCCTT AGGGTCTCAG GCTTTCACAC 010880 010881 CAGGGCAGGC CTTGGGCCAG ACTACCCAAC TTCCAGGCCG GATGTGCCAC CGGGGAGGAG GAGGTAACTG CCCCTCAAAA 010960 010961 CCCTGCAGCC CAGGGCTCCA GGATTCCAAC CCAGGGACCT GCAGGCTCCC CTGCTCTCCA GATCAGACCC CTACTCTCAG 011040 011041 AGCCCTAGGC CCAGTGGGTG ACAGCCTGTG AGACAGGCCT GTGTGGGGTG GCCCTAGCCC CACCTCAGCT TCCAACCTGA 011120 011121 CCTTGCTGCA TGACCTCTGG CCCAGCCCTC TCCACCTGGA GTGCCATCTC TCTTTGTGGG ATGGGCCAGG TGGGCTGTGT 011200 011201 GTGGGGGAGG GCAAGTATAT AGGTGTGGTA TAGGTGGAAA CTGCCACAGT AACCAGCAGC AGCTCAGAGC CGGGCCACCC 011280 011281 AATTTGTATG CCAGCCCCAG CTGGGCCTAG GCACGTGGTG TGTGGAAATG AACGAAGCAG GCAGCCCTAT GTTTAGGAGG 011360 011361 CAGGTCCAGA GCTCACCCAG GCACAGCACA AGATGAGTGC CTGGCCTCAG TGAGCGAGCA CTGGCTGCTA TGAGGCTGTG 011440 011441 GTGTGGAACC TTGACACTAG GGCCACTGGC CTGGCTGTGT GACCTCTACC TCATCACCCA GAGCAGGGCA ACCAGAGGCA 011520 011521 GAGCCTCAGT GTGGTGTTCT CCTGTGAAAT AGTGATGGCA CAGGCAGGGG CTGGGGCCCA GTGCCTACAC AGAGGATCAG 011600 011601 CAAAGGATGG CAGTTATTGA AACCTCTACG GGGAAGTTCC CCAGACACGA GAGGAAGACC CCCATGGAAG CTGTGTGTGT 011680 011681 GACGTGCTTA GATTTTCCAG AGTCTTCATT TTCCTTGTCT AAACAGAGGT CATGGCGCCT CCCTCTCAGA TCAAACAGCC 011760 011761 CTGTATGAGT GGCTACAACC TTTGGTGGGC TCAGTGCAGC CCCTCCTGCC CCCTTGCTTG GGAGCTGTCT GCAGAGGCCT 011840 011841 AGGGAGCTGC GTGGGGTCTC TCCACCTCAG CCTGTATCCC CACCCCCACC AGGTCCCCTG CCTGACTCCA GCATACCCAG 011920 011921 GCCCTAGAAG CACCAACTCC ATGGCTGCAG CTGAGTGGAG TGTGTGCCTG CCCAAGCCTA GAGGGGTGCT GACCCCTCCC 012000 012001 TCGCACGAGG AGACATCAAA GGGAAGCAGG AAGCAGCGGC CTGGCTGACC CACAGCGGGT GGGAGAAGTG CAGCCTCACA 012080 012081 ACTGCTGGGG ATTTTCCATC CCACCAGGAT TTCCGCGGGA CACCCCAAGT CCAGCCTTTG AGGCTCCTCA GGAACCAGAG 012160 012161 TTTGGCCTGG AGCCAGTTGG GGCAGAGGAG GGGGGCCAGG CTGGGTGGCT TAGGGGTGTG GTTAGGCCTG CTAAGGGGCT 012240 012241 CCTCTTCTCA GTCTCCCCAT GATTTGCTGG TTACTGGCTT GAAATCTGGG CCCAGACCCA TTCCAACACT GAACCCTGAG 012320 012321 CTCCCTGAGA CCTGGCTGGC AAGGACAGGT CCCAATTTTT ACAGGGGCCT GAGAGGAATG GAGAAGGGAT CTCTGCCCCT 012400 012401 TCCTTTCTCA GTCACACCTC CTTGACAGGG GGTCATCAGA GTGGGCTGTG GTAGGTGCAC CAGGGAAGGG ACCATACAGA 012480 012481 GGAGGCTGGT CTCAAGTCCT AGGGTGCCTG GGATGGCCCT ATTGAAATGC TGCAGCAGCT CTTGTGCAGG CAGGGATCTG 012560 012561 TATGGACAGC TGGGTGGACA CAGGTGCCTA CTGACCTCCC AGATCCTTCA GCAGAGCTCA GCCCTGAGTG ACAGCCCAAG 012640 012641 GCAGACCTGG CTACCTCAGC CTCTGGCTCA CAGCCCTCAG CCAGAGCCCT GAGAGGCCTG GGATCTCAAA GCTGCAAGGT 012720 012721 GGGAGGCCAG AGGAGAGAAG CCCGGAGCTG GTAGTGATGC TGGCTGAGTG AAAATTGCAC ATTTCCCAAC AGTGTGATGC 012800 012801 TCCCTATCCA GCCTGGGCTT TTGGCAGACT TCTGTGCTTT GTGGAGGAAG CTGGCTCAGA TTCCTCCCCT CCCTGTGCAG 012880 012881 TTTGTGTGTC AAGGTGTACT TGTCACACCC AACTCAGGAT ATCTTGCATC ACTTTGTGGG TCCTTGTCCC CCAGAGCTGG 012960 012961 GACTGCTGAG TTTTAGCCCT AAGCTCTTGC TCCCATCTTA GCAAGTCAGG GCCCAGTGTT GTCCTTGCCT CTGCATCAGG 013040 013041 ATGGTAAGCT GGGCATGCTC CGCATCACGG AGACCTGCAT GGACCTGGAT TGGGTTGCCT CTATCTTCAG GCTGGTCACT 013120 013121 GGGCAGACAC AAACCAGGGC CTCTGGCCAG AGGGGACAGT GGCTCTGAGT TACTTGTGCT GCTCTTTAGG GGTGAGCAGG 013200 013201 GGCTGCTTGT GCATCATAGT GTATCACAGG GGATGCACAT TTACAATTGA AAGCTACTGG TCCTGGGTAG AAGTGGGGCC 013280 013281 GAGTAGGACT TCCCAGCCTT GAACATGGGT TTGTCATCCA ACTGGGACCC ACACTTGATC CAGCGGCCAT GCTCTGTGCA 013360 013361 GCCTGGGCCT GAGGGCAGCC ACGCTCATGT GAAAAGTGCT AGTAGCCAAG CTGCCATTCT AGTCACCACA GCTGTCCTTG 013440 013441 CAGGAGCACA TTGCCCAGGG CTGGGAGCTG TCATTTCCGT GACGGGAGTG AGACTCAACA CTGGGTGAGG GTGGGGGTAT 013520 013521 CTGTTGGGAA TTATTTCAAA ACAATTGTGG AAACTTGGCA GTGGAGGGGC TCTGGGCATA GGTATCCACA ATATCCTAGT 013600 013601 CAGGGGTTGG GGTACCCTGG CTCTGCTGAT AAGCCCAAGT GAGCATACTC CTCCCCCAGC TTGGAACAGG TGGGACGGGC 013680 013681 CAGGTGACAC TAGTGTGGTC TGTGGTCTGG CCTCCCAAGC CAGTGGCAGT ACTGGGGTGG CAGACATTTG CTGTGTGCTA 013760 013761 TCCCAAGGCC TAAAGGTCAC ACAGCTAGGT TGGAGCAGGG TTTTGGGCAG GATGAGTAGG CATTGCTGTG CTCTCAGAAA 013840 013841 GGCGAAGCAA ACCCCAGAAG CAAGGGGGCG AGACAGGGCA AAGGCCTACA CTTTGCCATC AACTCAGGCC TACTCAATGC 013920 013921 TGGCCCTGTC CTTCCCCTGC CCCTGCCCCA TCAGATGGTG CGAGCTGGCG GGGCTTAGAG TGAGCCCCCC TGACTCTTCT 014000 014001 TGGTGTGGAG TCTGAGGCCC AGAGTGTACA GGCCTCATCC GTGTGACCCA GCAGGAGGAT GGGAGAGTGG GCCCAGAACT 014080 014081 TGGTCAGGCT CATCCGTGGA GAACAAGTTC TTCCCTAGTC TAGTTGTGGT CTGAGTCCTG GGTGAAGCAG GAGGCAGCCT 014160 014161 GGGAAACAGC CTCGTTCTAG TAGGAATCGC ATTCTCAGGA ACGCTGACTG TGCAGGGCCC TTTCTCACTG CCACCTGGGA 014240 014241 GGATGCCTGC CTGCTGGCCA TTTCGGCGGA CTGTCAGAGC ACCCTCCCTG GGGTCCCAGA CCGAAGGCCT GAAGTCCACA 014320 014321 TGGGACCCCT GAACTTCTGG TACCTGTGTG GGCTTGTCCC CTCAACCCTG AGTGGAATGG CAACAGCCAG CTGCAACCCT 014400 014401 CCTAGCTTCC TGTCATGTGC TGTATGGAAG GGCCAAGAGC TGTAGTCATC TGCAGATCCT CCCACTGCAC CTGTAGGACT 014480 014481 AGCGTCTCCT GTCTGGATGT GAGCAACTTG CTGGTGGCCT GTGAGATGGG AGTTGCACTG GGCTTCTGGA TAAGGGCTTC 014560 014561 TCGTTCAGGT GACAATTCTA TGTGAAGGAG ACCCATGGAA ACACATCTAT CCCCTGCCCA TGTACCAGGC AGAGATGGTA 014640 014641 CCTGCCCATG TACCCTCCAT GACATGGCTG GGTCCCTGAA ACATCAGACA GATCGATACT CTGTGTGCAT GTTTGTGGGC 014720 014721 AAGACACAGT GGCACGTGTG CCCTGGAGTT TGGTAATGGG AGGACTGAAG TAGTGCCTCC GTGTGTGAGC TGTGCCAGCC 014800 014801 ATCCCCACGA AGGGGGCATT CCATGCAGAT GGGGATCCTC TCCAGGCAGC TTCTTCCACA CCTGATTAGC TCTGACCATC 014880 014881 AGACCCCCCG TGCCAAAAGG GCCCCTTCCC TGGAATCTGT AATTCTCACA GGCTGTCCCA TACATTTTAA ATCCAGGAAA 014960 014961 TGTGCTCACC CATGAGACAG GGATGGCAAG AAGATATGAA TGAAAAGCAA CCAGTCCGTA AAATTGGAAG CCATTTCACT 015040 015041 CCTTACCAGG TACAAAGATA ACATGCTGCA TGGATCAGGG ACACAAACTT ACCTACCTTA TGATGTAGTG AAAGAATCTA 015120 015121 AAACTTTTGT CTCAGCAGAC TCCCTGGAGG AAGCCAATAA CAGGAGGCCT TGACTAGGAG ACCTCAAGCC TTGGAATGTG 015200 015201 CCCAGACCAG TGGGGAGGGA AGGCTGGGAG GCAGTCCTCC CTTACCCCTT TTCTCCCAGG CAGACCTACC CTGGGTTCTC 015280 015281 TCCAGGCCCC TCCGCCTGAG CAAGTGCTCA GTTGGCCACT AGCTCCCTGC ACATCCAACA AGCCTTTCTT TCCTGTTCCT 015360 015361 TCTTCAAGGA AGGCTTAGCC TCAAATCCAG GGCCACAGAC AAAGGACAGT CACTCTCCTC TGCCAGAAAG TCATTTATGG 015440 015441 GACATGGAGA AAGCATCAAA TATATTGCTT TTCCAACACC TAACAGTGGA ATAGGAGGAA TAGAAGGAGA ACTCAGCCAG 015520 015521 AAAGTTCTGG AGCATAGTCT TTTTGCCAAA AGAACACGTT TTCAAATGAA AGAGGTGGTG CTGGGGCACT GAGGAATCAG 015600 015601 GGGGATGGAC CCCACTGGAG CTTGTCTCAT GCTGGCAGCA AGTCCCAGGC CTCAAACACA TACCTGGGCC ACCTCAGGAG 015680 015681 AGAGACTGCA GGGAAGAAAT GAGTTGCAAT GCTCCAGCCT AACCAACTCC CCTTTTGTTA ATCCAATCCC AGAAGGTACT 015760 015761 GGGTAGGGTC AGTTAACAGA CAGCTGCCTG TCTCCTGGCA GAGTCTGACC AAGCCCCAGT GGGCGCTTCT CTTCCTAAGT 015840 015841 CCTCTGGTGT ACCCCATTCT TCAAGGGAAA CGGTCCCCTT AAGAATCTAT GTGAAAGGGT TCTGAAATTG CTGTACCAGT 015920 015921 TAATGAATTA TTTACTCTAA ACAATGTCTT GATAAAGGGG GAGGATGAAG TTAGCTGATG TTGACTAAGG AGAGACGGAG 016000 016001 TTGCCAAGGA AATTCTTCTA AATGAAAAAA AAAAAAAAGT AAAAGCAGTC AGCTGGTTTT GTCTGACTAT GAAACGTGTC 016080 016081 ACAGAGCATG CACCTTTGGC CATCTTTTGC ATTTATGATT TGGAAGAGAG ATGTAGCAGT GAGTGTGGGG CCAGGGAGGG 016160 016161 GAATCCAACA AAGCCATTCT GCAAGCTAGT GGCTGGGATT TTGGGGTATA GAGTAAGAGC AGCCAGCCTT AGAGGCCCAT 016240 016241 GTCATCTGGG CTGCCTCAGA GCTAAAGCTA GGTAACCAGA GGGAGTAAGG AAAGGCCTGA GTCCCAGGCT AGGCTTTTCA 016320 016321 CAGTTGTATT GAGATGGGAA AGTAAGGGAT GTTCCTTGCA GCAGATGCAG GGCCCAGTTG TCTAGAGCAG TATTTGAAAT 016400 016401 GAGTTGGCAT TTCAGGGCAG TGTTTGTGAT GCCAGTCAGT AGGTAGGGGC TTCTACCTCT TTTTTAGAAA TGTTTACTCT 016480 016481 GAACTAAGCT CTATGCTTTA ACAAGTTATG TTTTAATAGG AAAACTGTCA TTGATGGAAT CATATGTAAT TCCTACATTT 016560 016561 TTCCAGTTAC CCATTCCTGG GGAAAGCTTA GCCATTGGAC AAACCACCCA GAGCCCCAGG AACCTGCATT TGCAGACAGC 016640 016641 AGTGGCAGGC ACAGTGGCCT AGTGTTGAGC GGGGGAAACC TGGCCTCTAT GTGTCTGGTT TTGCAAACTA AAACGCCATT 016720 016721 GCCCATACTC AGGCTGACAG GTTCTGGAGG TGCCATGGAC TCCTGCTCTG TATCTCACCT CTAGTTCCAT CACAATGCAT 016800 016801 GAGCTGTCAG TGGGAGCCTT TTAATGCAGA TGCTAATACC CATTCCTAAT GCTAGCCCAT CCCCACACCC TCCTGAGTTG 016880 016881 GTGCGATATA TCCTGGGAAC AAGAAAATCT GAAGGCTCCT GGTCCTCAGG CTAGCAAGAG CCTTGCCTGT AAGAAGTGGG 016960 016961 AGAAGGTCAC CTCTCTCAGG AGGCAGAACT AAGGCTGCAC AGCACAAGGG AGATGTCTGA ATGCACAGTC TGGGTGGCAG 017040 017041 AAGGACTCCT GTCCTTTCTT CCACACAGAC CTGAGCACCT CTCCAGGTGC CACCATTTTC TGTCTGGGAA CATCTGCTAT 017120 017121 CCCCAAGCCT CAGTTTCCTG GTCTACAAAA CTGAGATGGT CTCTTCTATA CAAGGCCCCA GGAGGATCAC TGCAAGTCAC 017200 017201 TGCATTTCAT GGTGCCCAGA TTTCCCTGCA TTTCTAGAAT GTCAACAGAG ATGAGTGGGC TCAAGGGGAA GAGATTCTTT 017280 017281 ATGACTAGAG ATATTCTGGT CAACTTTGGA CCCCAGCTTC TATGGACAAT AGCATGTGGA CATGAGCCCT GGGGAAGCAG 017360 017361 GGATGACTGA GCCTGAAGAA GAGCTCTCAA GCCTTACACT CTCCAGACCA GCCTTGGGTT GCCTGAACCC CAGCATAGCC 017440 017441 TTATGGAACC CCTGCCAGGG TCCTAGCACC TGGTTTGACC TGGGCACAAG TACTCACTCA CTCACTCACT CACTCACTCA 017520 017521 CTCGTCAAAC ATTCACTGAG GGTCCGTGAC AGGCTCCATA TGGATTAAGC ACTGAAGATA AAACACTGAA TAGAAACAGC 017600 017601 CAGCCTATAC CCTCATGCTC CTTGAATGTG ATAGAAGGAG CCAGCCAGTA AACCCTTTAC CACAAATAAA CACACAGTTA 017680 017681 CACATTAAGA ATGGGAGGGG AGGTATGTGA TTTTTTACAG CCCAGTCTTA AGCTTTAGAA ATTGGCTCCT CTGAGGAAGG 017760 017761 GACATTTCAG CTAAGAACCA CAGGATAAGA CAGTCCTGGC CTGGGGAAGG GGAGAGAAGG TCAGGAGAGA GCTTGATATG 017840 017841 TTTAATACTG AAAGAATATT TGATGAGCTG GGACATCTCC TGCAGATCCA CGGCTCCCTA GCTTTGTGAC CCTGGGCCCT 017920 017921 AGACTCAATC CCTCAACCCT TAGGAGATTA TCTATAAAAC AGGAGTGATA ATATTCTTGT GTTAAAAGCT GCTGTGAGGA 018000 018001 TTAGTGAAAT GATGTCTATA TTTGCCTGGC AAACAGGAAG TGTAAGTAGT AGTATCATTT GAAGATTATT CTTCAGCCTA 018080 018081 AACGTGTGTT CATTATGGCC GGTGTGTTTT CTCCCCACCT AGATGGTAGT GCTGGGCCTC CTTTGGAGTA CCTTGATGTT 018160 018161 TGGGGAGCAT GGATGATATG ACCATAACCT GAGAAGGCAG GGACTGTACC CATTCTGGTC CTCCCAGGTC CCAGGGCCCC 018240 018241 CACAGTGCCC TGGTGTGTGA TCAGTGCCCA CAATACTGAA TAGAGGAACA GACACATGGG AAGCAACGGC AGCCTGGTCT 018320 018321 TTAAGGGTGA GGGAGCACCT TCTCCTGAGA GAGGGAGAGA TAGGTTGGGG GAGGTTGGGT GGGGGTGGGG AGAGCGAGTG 018400 018401 AGCAAGCAAG CTAGAAACTT CCTGAAAAGG GAAGTTACTC TAGAAAAGGG TAAGTTCCTT CCAGGCATCA TGGGCTGGCT 018480 018481 TAACCTGGAC CAGTTTGACT TTACTAAGTC CCATTTCTCA TCTAGGGAGC CTGAGGCCAT TAAGGTTATC TGGTCCCAAA 018560 018561 ATCCCCTAGA GCTGTCACAG GGATCCCCAT TCTTTGCCTT TAGTCACCCC AGCCCCAAGA GCCATCCTCC ACATGGAGTG 018640 018641 AGCAGGGAGC TACAAGGAAA AGACGGTCAC AGTTGGAGAG AGACAGAGAA CCAGGTGGGC TGGTAGGACA GGAAGGTATA 018720 018721 GGGAGAAAGT GAAGCTCTCT CCTGGGGAG