NONHSAT102247

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Annotated Information

Name

ncR-uPAR

Characteristics

~400 bp. RNA polymerase II transcript. Found several kb upstream of the human protease-activated receptor-1 (PAR-1) gene.

Mostly made up of repeat sequences including an Alu element.

Function

ncR-uPAR can act in-trans to stimulate PAR-1 expression.

ncR-uPAR binds nuclear proteins in-vivo, which could provide a mechanism for it to positively regulate the PAR-1 promoter during embryogenesis.

Expression

Expressed during embryonic development.

Presence of the ncR-uPAR promoter sequence drives expression of a transgene during embryonic vascular development at E9, which recapitulates PAR-1 expression at E9 quite well. At E16 expression was seen in brain and in arteries but not veins.

Conservation

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Misc

Refseq ncR-uPAR appears to be the ncR-uPAR promoter and the lncRNA sequence. UCSC genomic co-ordinates are to this Refseq annotation, while the sequence provided is from the identified transcriptional start site to the end of the polyadenylation sites (exact 3' terminus is unknown).

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT102247
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	432 nt
Genomic location	chr5+:76008228..76008713
Exon number	1
Exons	76008228..76008713
Genome context
Sequence	000001 TCTTTTGAAG GAGAAGAGGT AAAAAATAAT CAGTTCAAAA AATTATACTA AAGAGGCCGG GCGCGGTGGC TCACGCCTGT 000080 000081 AATCCCAGCA CTTCGGGAGG CCATGGCGGG CGGATCATGA GGTCAGGAGA TCGAGACCAA CCTGGCTAAC ACGGTGAAAC 000160 000161 CCCGTCTCTA CTAAAAATAC AGAAAAATTA GCCGGGCGTG GTGGCAGGCG CCTGTAGTCC CAGCTACTCA GGAGGCTGAG 000240 000241 GCAGTAGAAT GGCGTAAACC CAGGAGGCGG AGGTTGCAGT GAGCCGAGAT CGCGCCACTG CACTCCAGCC TGGGCGATAC 000320 000321 AGCGAGACTC CGTCTCAAAA AAAAAAAAAA AAAAAATTAT GCTAAAGAGT AAACTCAAAG AAAGTAGAGG AAAAGAATGA 000400 000401 ATTAAAAATC TGTGTTTATA AATAAAAATA AA

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Annotation (From lncRNAdb)

[NONHSAT102247]

Section	Description
ID	ncR-uPAR
Characteristics	~400 bp. RNA polymerase II transcript. Found several kb upstream of the human protease-activated receptor-1 (PAR-1) gene. Mostly made up of repeat sequences including an Alu element.
Expression	Expressed during embryonic development. Presence of the ncR-uPAR promoter sequence drives expression of a transgene during embryonic vascular development at E9, which recapitulates PAR-1 expression at E9 quite well. At E16 expression was seen in brain and in arteries but not veins.
Function	ncR-uPAR can act in-trans to stimulate PAR-1 expression. ncR-uPAR binds nuclear proteins in-vivo, which could provide a mechanism for it to positively regulate the PAR-1 promoter during embryogenesis.
Misc	Refseq ncR-uPAR appears to be the ncR-uPAR promoter and the lncRNA sequence. UCSC genomic co-ordinates are to this Refseq annotation, while the sequence provided is from the identified transcriptional start site to the end of the polyadenylation sites (exact 3' terminus is unknown).
Name	ncR-uPAR: non-protein coding RNA, upstream of F2R/PAR1

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