Difference between revisions of "NONHSAT035776"
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==Annotated Information== | ==Annotated Information== | ||
+ | ===Name=== | ||
+ | TEA ncRNAs: T early alpha | ||
+ | |||
+ | ===Characteristics=== | ||
+ | TEA ncRNAs transcripts originate from the TEA ncRNAs promoter at the 5' of the array of joining (J) gene segments of the T-cell receptor alpha chain (TCRA) [http://www.ncbi.nlm.nih.gov/pubmed/3500476 (de Villartay (1987))]. Another noncoding transcript has been identified coming from a promoter within the J array (J-alpha 49).<br /> TEA ncRNAs transcription extends up to ~71kb, covering the length of the J array and terminating in the C alpha region [http://www.ncbi.nlm.nih.gov/pubmed/3500476 (de Villartay (1987))]. . Full length of actual spliced TEA ncRNAs transcript reported as ~2kb [http://www.ncbi.nlm.nih.gov/pubmed/3500476 (de Villartay (1987)], [http://www.ncbi.nlm.nih.gov/pubmed/8383995 Shimizu (1993)]). ~4.5 and 8kb transcripts have also been reported. Transcripts generally include TEA ncRNAs sequence spliced to C alpha and sometimes include J segments [http://www.ncbi.nlm.nih.gov/pubmed/9247569 (Villey (1997))]. | ||
+ | |||
+ | ===Function=== | ||
+ | TEA ncRNAs transcription regulates V alpha-to-J alpha recombination and is necessary to generate the full complement of recombined segments ([http://www.ncbi.nlm.nih.gov/pubmed/16936730 Abarrategui (2006)], [http://www.ncbi.nlm.nih.gov/pubmed/17882258 Abarrategui (2007)]).<br /> Transcription has both activating and repressive effects on the promoters of different J segments. Segments only a small distance downstream from the TEA ncRNAs promoter are activated while segments more distal are repressed, with alterations in histone modifications and chromatin accessibility ([http://www.ncbi.nlm.nih.gov/pubmed/16936730 Abarrategui (2006)], [http://www.ncbi.nlm.nih.gov/pubmed/17882258 Abarrategui (2007)]).<br /> These effects target initial recombination events to the active proximal J segments. In the absence of TEA ncRNAs ncRNA transcription recombination occurs in more distal J segments which are normally repressed ([http://www.ncbi.nlm.nih.gov/pubmed/16936730 Abarrategui (2006)], [http://www.ncbi.nlm.nih.gov/pubmed/17882258 Abarrategui (2007)]).<br /> Repressive effects of the TEA ncRNAs ncRNA suggested to be due to transcriptional interference. Unknown if TEA ncRNAs ncRNA also has a function itself, ie: recruitment of chromatin modification complexes ([http://www.ncbi.nlm.nih.gov/pubmed/16936730 Abarrategui (2006)], [http://www.ncbi.nlm.nih.gov/pubmed/17882258 Abarrategui (2007)]). | ||
+ | |||
+ | ===Expression=== | ||
+ | Expressed during thymocyte development at a time recombination is occurring ([http://www.ncbi.nlm.nih.gov/pubmed/16936730 Abarrategui (2006)], [http://www.ncbi.nlm.nih.gov/pubmed/17882258 Abarrategui (2007)]). Expression is highest in fetal thymocytes and is absent in mature adult T cells ([http://www.ncbi.nlm.nih.gov/pubmed/3500476 de Villartay (1987)], [http://www.ncbi.nlm.nih.gov/pubmed/8383995 Shimizu (1993)]).<br /> TEA ncRNAs transcripts have been identified in the nucleus [http://www.ncbi.nlm.nih.gov/pubmed/17882258 (Abarrategui (2007))]. | ||
+ | |||
+ | ===Conservation=== | ||
+ | Humans and mouse ([http://www.ncbi.nlm.nih.gov/pubmed/3500476 de Villartay (1987)], [http://www.ncbi.nlm.nih.gov/pubmed/8383995 Shimizu (1993)]). | ||
+ | |||
+ | ===Misc=== | ||
+ | V(D)J recombination acts to assemble the variable regions of T cell receptors from germline variable (V), diversity (D) and joining (J) gene segments.<br /> RNA accessions from [http://www.ncbi.nlm.nih.gov/pubmed/3500476 de Villartay (1987)] and [http://www.ncbi.nlm.nih.gov/pubmed/8383995 Shimizu (1993)] some are spliced some are not.<br /> Human 147: GenBank: M18204.1. Human 147A1: GenBank: M18206.1. Human 147A19: GenBank: M18205.1. Mouse T early alpha (TEA ncRNAs) region: GenBank: D13547.1 | ||
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===Transcriptomic Nomeclature=== | ===Transcriptomic Nomeclature=== | ||
Please input transcriptomic nomeclature information here. | Please input transcriptomic nomeclature information here. | ||
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===Regulation=== | ===Regulation=== | ||
Please input regulation information here. | Please input regulation information here. | ||
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===Allelic Information and Variation=== | ===Allelic Information and Variation=== | ||
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[[Category:Intergenic]] | [[Category:Intergenic]] | ||
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Revision as of 01:25, 11 October 2014
Please input one-sentence summary here.
Contents
Annotated Information
Name
TEA ncRNAs: T early alpha
Characteristics
TEA ncRNAs transcripts originate from the TEA ncRNAs promoter at the 5' of the array of joining (J) gene segments of the T-cell receptor alpha chain (TCRA) (de Villartay (1987)). Another noncoding transcript has been identified coming from a promoter within the J array (J-alpha 49).
TEA ncRNAs transcription extends up to ~71kb, covering the length of the J array and terminating in the C alpha region (de Villartay (1987)). . Full length of actual spliced TEA ncRNAs transcript reported as ~2kb (de Villartay (1987), Shimizu (1993)). ~4.5 and 8kb transcripts have also been reported. Transcripts generally include TEA ncRNAs sequence spliced to C alpha and sometimes include J segments (Villey (1997)).
Function
TEA ncRNAs transcription regulates V alpha-to-J alpha recombination and is necessary to generate the full complement of recombined segments (Abarrategui (2006), Abarrategui (2007)).
Transcription has both activating and repressive effects on the promoters of different J segments. Segments only a small distance downstream from the TEA ncRNAs promoter are activated while segments more distal are repressed, with alterations in histone modifications and chromatin accessibility (Abarrategui (2006), Abarrategui (2007)).
These effects target initial recombination events to the active proximal J segments. In the absence of TEA ncRNAs ncRNA transcription recombination occurs in more distal J segments which are normally repressed (Abarrategui (2006), Abarrategui (2007)).
Repressive effects of the TEA ncRNAs ncRNA suggested to be due to transcriptional interference. Unknown if TEA ncRNAs ncRNA also has a function itself, ie: recruitment of chromatin modification complexes (Abarrategui (2006), Abarrategui (2007)).
Expression
Expressed during thymocyte development at a time recombination is occurring (Abarrategui (2006), Abarrategui (2007)). Expression is highest in fetal thymocytes and is absent in mature adult T cells (de Villartay (1987), Shimizu (1993)).
TEA ncRNAs transcripts have been identified in the nucleus (Abarrategui (2007)).
Conservation
Humans and mouse (de Villartay (1987), Shimizu (1993)).
Misc
V(D)J recombination acts to assemble the variable regions of T cell receptors from germline variable (V), diversity (D) and joining (J) gene segments.
RNA accessions from de Villartay (1987) and Shimizu (1993) some are spliced some are not.
Human 147: GenBank: M18204.1. Human 147A1: GenBank: M18206.1. Human 147A19: GenBank: M18205.1. Mouse T early alpha (TEA ncRNAs) region: GenBank: D13547.1
Transcriptomic Nomeclature
Please input transcriptomic nomeclature information here.
Regulation
Please input regulation information here.
Allelic Information and Variation
Please input allelic information and variation information here.
Evolution
Please input evolution information here.
You can also add sub-section(s) at will.
Labs working on this lncRNA
Please input related labs here.
References
Please input cited references here.
Basic Information
Transcript ID |
NONHSAT035776 |
Source |
NONCODE4.0 |
Same with |
, |
Classification |
intergenic |
Length |
506 nt |
Genomic location |
chr14+:22942568..23016567 |
Exon number |
2 |
Exons |
22942568..22942930,23016447..23016567 |
Genome context |
|
Sequence |
000001 GAATTCATGT CTTACGGTCA AGGGCTAGAG AAAGGATTTC TGCATCACTT TCTTCCTGTA GCAATTCCAT CCGAGATCCC 000080
000081 TGGGACAGAC CTGGCCTGAT GAATAGCAGG AAGCACACCA GGGAGGGACA AGGTCCTGCA GACAACCTTC ACCACCAGGC 000160 000161 TGGGACAGCG CCATGGGGAC CCAGGGCCTC TGCTTTGGGG AAAGACCTTG CTGAGGGGCC CCATGGGCAA GAACAAGTGT 000240 000241 GAAGAACCCT ACTATGGTTT TTTGCCCAAT GCCCTCCACA AAGCCAGCGT TTGAAGGAAA ACTGTGAGGA AGAAGGGACA 000320 000321 CTCCATGGTG TTGTTGTTGC CACCTCTGGA GCAGCCTGTA GCAAGAACAG TCTTGGTCCA ACCAGATATC CAGAAGCCTG 000400 000401 ACCCTGCCGT GTACCAGCTG AGAGACTCTA AATCCAGTGA CAAGTCTGTC TGCCTATTCA CCGATTTTGA TTCTCAAACA 000480 000481 AATGTGTCAC AAAGTAAGGA TTCTGA |