NONHSAT122918

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Annotated Information

Name

ST7OT

Characteristics

Four noncoding RNAs from the RAY1/ST7 gene locus. Complex gene locus with a large number of coding and noncoding isoforms. ST7OT1 & 2 are antisense to ST7. ST7OT3 & 4 are on the sense strand. ST7OT1 - ~2kb unspliced antisense transcript that initiates in intron 1 of ST7, covers the first exon and terminates in the ST7 promoter region. Polyadenylated. Nb: it also overlaps exon 1 of ST7OT4. ST7OT2 - Spliced antisense transcripts. Multiple isoforms that share either some 5' or some 3' exons. Isoforms are between 900-1300 bp, with 4-6 exons and polyadenlyated. ST7OT3 - Spliced ~1kb transcript. Begins in intron 10 of ST7, shares exons 11-13 and sometimes 14 & 15 with ST7 plus has a number of unique exons. Some exons may also act as a alternative 3' end for ST7. ST7OT4 - Multiple spliced transcripts within the long first intron of ST7. However, Refseq ST7OT4 transcript may be protein coding. Transcription begins just ~200bp downstream from the end of first ST7 exon.

Function

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Expression

ST7OT1 - abundantly expressed in testis, also expressed in cerebellum, skeletal muscle, uterus, cerebellum, spinal cord, fetal brain, and prostate. ST7OT2 - testis, fetal brain, cerebellum, mammary gland, fibroblasts. ST7OT3 - expression only detected in cerebellum. ST7OT4 - no expression detected.

Conservation

ST7OT1 - some conserved sequence with mouse, most of this is where ST7OT1 overlaps the first exon of ST7 however. ST7OT2 - 3' end of some isoforms shows some conservation with mouse. ST7OT3 - some conserved sequence, most of this is shared exons with ST7 though. ST7OT4 - sequence not conserved with mouse.

Misc

ST7OT1 - NCBI Gene ID: 93653. ST7OT2 - NCBI Gene ID: 93654. ST7OT3 - NCBI Gene ID: 93655. ST7OT4 - NCBI Gene ID: 338069

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT122918
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	416 nt
Genomic location	chr7+:116594674..116608628
Exon number	3
Exons	116594674..116594733,116595028..116595207,116608453..116608628
Genome context
Sequence	000001 CGAAACACAA AGTAAATTTC GAGCTAAGGG TTACAGTCCT TTAAATCTGG AAATTTCAAG TATCCCTCGG GATCGTGTCC 000080 000081 CTGGGAGGCG GATAGGATTC AGCACTCTAG AATTGTCTCA CCATTTGAAT AGGTGCTGCT CAGCCCTTTT GAGTCTGTCA 000160 000161 TCGGAAAGAC CATGGCTTTC TCGCTTTTCA TCTTTTTGGA TGGCTGCTTG TCGCAATATT GTCTTCTTCG CTTTAGACAA 000240 000241 tgtcttacta tgttgaccgt gctggactcg aattcctggg ctcaagcaat ccttctgcct caaccttctg attatttcga 000320 000321 ctacgggtgt gcgccaccat gcctggcTTA GAAAAGGACT TTATGTTGAA CCTCTTTTCT CTTACAATCA AATAATAAAT 000400 000401 TCATTGAGTC ATACTA

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