ABHD11-AS1
Contents
Annotated Information
Name
Approved Symbol:ABHD11-AS1:ABHD11 antisense RNA 1
Synonyms:NCRNA00035, WBSCR26, LINC00035
RefSeq ID:NR_026690
Ensembl ID:ENSG00000225969
LncBook ID: HSALNT0288881
Chromosome
7q11.23
OMIM ID
612545
characteristics
ABHD11-AS1 RNA is an approximately 473-base-long transcript processed from 4 exonsin human. [1]
ABHD11-AS1 and its mouse homolog Abhd1os contain 2 small potential ORFs (ORF1, 105 nucleotides and ORF2, 138 nucleotides in mouse), which are conserved across mammals. [1]
Function
Abhd11os has a neuroprotective effect against mHtt. [1]
Expression
Abhd11os levels are markedly reduced in different mouse models of Huntington disease (HD) [1]
Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin, whereas Abhd11os knockdown is protoxic.[1]
Compared with adjacent non-tumor tissues, the expression level of ABHD11-AS1 in gastric cancer tissues was significantly increased. [2]
| Primer | Forward primer | Reverse primer |
|---|---|---|
| RT-PCR | Abhd11os-U GGATTGCCTCGGACCTG | Abhd11os-L GCACCCGCTCTCGAAC [1] |
| Knockdown | Abhd11os-directedsmall hairpin RNA (shRNA) | 5'GGGATGAAGCCATTGCTAA 3' [1] |
| Luciferase-targeted shRNA | 5'CGTACGCGGAATACTTCGA 3' [1] |
Disease
ABHD11-AS1 might be a potential biomarker for diagnosis of gastric cancer. [2]
pubmed IDs
24984296, 25619660
Sequence
000081 CCTGACAGCA ACATCAAAGC CGAGGCCAAG GCGGGAGGGC CCAGAGTGAG ACACCTCTTC CAGACAAGAC TTGGTCGCTG 000160
000161 CCTCCTCCTC TGTCACCCTG CGACACAGCC CAGAGTACCA GGCGGCTGGA GCACTGGGGG ACACCCGGAC AGAACCCTCC 000240
000241 CTGGACCAAG TCCTCCAGGA ACGGGATGAA GCCATTGCCA AGAAGCAGGC GGTGGAGGCG GAGCTGCAGA GATGCAAAGC 000320
000321 CAGGCTACAC GCCATGGAGG CCCAGCTGCT GGAGGTCCTG GAGGAGAAAC TGAGGCTGAG GCGGGAGCTG GAGGCCTGGG 000400
000401 AGGAGGACGT GCAGCAGCTG GTGTGGCAGC AGGTCCAGAA TCAGCTGCAG AGAGAGGCCA AGGGTACTCG GGG
Labs working on this lncRNA
- CEA, DSV, I²BM, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France[1].
- Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, 315211, China.[2].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Francelle L, Galvan L, Gaillard MC, Petit F, Bernay B, Guillermier M, et al. Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo[J]. Neurobiology of aging. 2015,36(3):1601 e7-16.
- ↑ 2.0 2.1 2.2 Lin X, Yang M, Xia T, Guo J. Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance[J]. Medical oncology. 2014,31(7):42.
