MAFTRR

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Annotated Information

Approved Symbol

MAFTRR

Approved Name

MAF transcriptional regulator RNA

Previous Symbols

_

Synonyms

linc-MAF-4

Chromosome

16q23.2

RefSeq ID

NR_104663

OMIM ID

616264

Ensembl ID

ENSG00000261390

pubmed IDs

25621826

Characteristics

linc-MAF-4,a TH1 signature lincRNA, localized 139.5 kb upstream of the MAF gene [1].

Cellular Localization

linc-MAF-4, a chromatin associated CD4+ TH1 specific lincRNA [1].

Function

Linc-MAF-4 plays a key role in T lymphocyte differentiation [1].

Regulation

Linc-MAF-4 down-regulation skewed T cell differentiation toward TH2 [1].

A long-distance interaction between linc-MAF-4 and MAF genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated MAF transcription by recruitment of chromatin modifiers [1].

Diseases

File:MAFTRR.png
Figure: LincRNA signatures of human lymphocyte subsets. [1].
  • allergy
  • autoimmunity
  • cancer

Expression

Sequencing data showed that high expression of linc-MAF-4 correlated with a low amount of MAF transcript in CD4+ TH1 cells, conversely TH2 cells had low expression of linc-MAF-4 and abundant MAF transcripts [1].

No correlation was observed between the expression linc-MAF-4 and its proximal upstream protein coding genes: CDYL2 and DYNLRB2 [1].

Sequence

>gi|559098521|ref|NR_104663.1| Homo sapiens MAF transcriptional regulator RNA (MAFTRR), long non-coding RNA

000001 TTTACCTGCT AGGCTCGTCC CACCTGTGTG GAGCTCCCAT CGCCCTCCAG CGTTGCGCAG CCTGAAGGGA CAGGACGGAC 000080
000081 AAGCGGGTGC CTCCTTCTAA TTCATCTTCA CCATTGTGGT TGTCAATATG GCATGCAGAA TTATCCCTCT TTCCAGGTTT 000160
000161 TCCCCAAGGA CCCTGGACAA TGCTGGTTTT TCCTATGTGC ACCACCAAAG GGCCTATCCA GCTTCTGGAG TCTACCTGGA 000240
000241 TTCCTGGGCT CATGGCCCCT TCCTCCATCT TCAAACCAGC AATGGAAATG GAAATGAAAG CAAAATGGAA GGACGTGAGG 000320
000321 TCCTTATCCT TGGAGATCCT ATGGAGTCTC CACAGACATT CCTTGAAGAA ATCAGATGGA GCTGAGCCTG ACACTCTAAC 000400
000401 CGGTTCTCTG GGTGTACTGC AAAGGTCTAA TAAAAGGCAC CTTTGCCCGG TTGCTTCAAT TCTAGGAAGC TGTTCAATGT 000480
000481 TTGACTATAT TTCTCCATAC TCATTTGAAA ACAGTTCATC AGGTTAGTTC AGTTGAATTA TTGCTCCTTG GGAGTTTTCC 000560
000561 AAACCCTGGA TTTCCTTCGG AGAGAGCTAG ATTCTATTCC ATTCTTGGAA TTCAGCTCCT TGCCCTTCTC TGTGACCCCG 000640
000641 GATCGCGAAT GCAGTAAAAA TAAAAATATC CTGCTGCCTC CTGCA

Labs working on this lncRNA

  • Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, 20122 Milano, Italy [1].

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Valeria Ranzani, G.R., I.P., A.A., R.JP.B.,S.C., P.G, E.P, E.S, M.M, R.De.F, J.G, B.B, S.A, and Massimiliano Pagani (2015) LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4. Nature Immunology, 16(3):318-25.
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