LINP1
Contents
Annotated Information
Expression and genomic alteration of LINP1 in breast cancer[1]
LINP1 RNA associates with Ku80 and DNA-PKcs[1]
LINP1 serves as a modular scaffold in the NHEJ pathway[1]
Approved Symbol
LINP1 (lncRNA in non-homologous end joining pathway 10
Chromosome
10p14
RefSeq ID
NR_138480
pubmed IDs
27111890
Expression
Compared with the non-basal lines, LINP1 has significantly higher expression level. [1]
Function
LINP1 serves as a modular scaffold and uses different regions to interact with the two proteins Ku80 and DNA-PKcs which participate in the NHEJ pathway. [1] Suppressing LINP1 expression can impair DNA repair activity in vivo, which in turn sensitizes tumors to IR treatment.[1]
Regulation
LINP1 is activated by the EGF (RAS-MEK-JNK) pathway and repressed by the p53 signaling pathway. [1]
Labs working on this lncRNA
- Center for Research on Reproduction &Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
