PRAL
Contents
Annotated Information
Name
PRAL:p53 regulation associated lncRNA[1]
Characteristics
LncRNA-PRAL is transcribed with a poly A1 tail, diffusely distributed both in the nucleus and cytoplasm, and localizes to both cytoplasmic and nuclear regions [1]. most of the sequence of the lncRNAPRAL overlaps in antisense with the 3' untranslated region of XAF1 protein-coding gene, which is known to regulate apoptosis[1].
Cellular Localization
LncRNA-PRAL (p53 regulation-associated lncRNA)localizes on chromosome 17p13.1[1].
Regulation
Function
LncRNA-PRAL could inhibit HCC growth and induce apoptosis in vivo and in vitro through p53. The three stem-loop motifs at the 50 end of lncRNA-PRAL facilitated the combination of HSP90 and p53 and thus competitively inhibited MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability[1].
Diseases
- Hepatocellular Carcinoma[1]
Labs working on this lncRNA
- Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China.
- The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, 200433, China.
- Department of Epidemiology, Second Military Medical University, Shanghai, 200433, China.[1]
