WWOX-AS1
Contents
Annotated Information
Name
Approved symbol: WWOX-AS1:WWOX antisense RNA 1
Alias symbols: RP11-190D6.2
HGNC ID: HGNC:53169
LncBook transcript ID: HSALNT0233849
Characteristics
LncRNA RP11-190D6.2 is the antisense transcript of protein-coding gene WWOX (WW domain-containing oxidoreductase) [1].
Function
RP11-190D6.2 may play a pivotal role in the regulation of tumor metastasis [1]. RP11-190D6.2 expression is positively correlated with WWOX expression (R=0.45519, P<0.00777), and WWOX is linked with poor prognosis in numerous cancers, including epithelial ovarian cancer (EOC) [1]. RP11-190D6.2 overexpression inhibits proliferation, migration, and invasion abilities in HO8910-PM cells, whereas RP11-190D6.2 knockdown in HEY-A8 cells shows the opposite effect [1].
Patients exhibiting high WWOX‑AS1 expression demonstrated a greater overall survival compared with patients exhibiting low WWOX‑AS1 expression. WWOX‑AS1 overexpression inhibited the proliferation, migration, and invasion of MG63 cells and knockdown of WWOX‑AS1 enhanced the proliferation, migration, and invasion of MG63 cells in SAOS2 cells[2].
Regulation
RP11-190D6.2 is restored by 5-aza-2′-deoxycytidine treatment in Epithelial ovarian cancer [1].
Diseases
Epithelial ovarian cancer (EOC) [1]
Osteosarcoma[2]
Expression
Compared with the matched non-tumor tissues, the expression level of RP11-190D6.2 in tumor tissues is markedly decreased. Meanwhile, the expression of RP11-190D6.2 is remarkably downregulated in tumors with higher Federation of Gynecology and Obstetrics stage (III/IV) compared with tumors with lower FIGO stage(I/II) [1].
WWOX‑AS1 expression was downregulated in osteosarcoma tissues. WWOX‑AS1 and WWOX expression were positively correlated in MG63 and SAOS2 cells [2].
Sequence
>XR_429776.2 PREDICTED: Homo sapiens uncharacterized LOC102724047 (LOC102724047), transcript variant X2, ncRNA
000081 TGGAACAAGG ATGAGGCAGG CAGGCTCTGA TAGCAACAGG AGGAAGCAGA CCAAGGAGGG AGAGAAAGGA AGGCAGAGAA 000160
000161 GGGGAAAAAA AAACACAAAT GATAATAATA GATGCTGACA TTTACGGAGC ACTTACTATG TGCTGGGAAC CATGCTGACG 000240
000241 GCACACCGAA TCCACTGAAC AGATCTCTTT GGGTTTTGGA ATAACAAAAA AGGGACTGTA CATGGATATT TCCAAGCTGG 000320
000321 AACCGAGGCA CTTTCTAGAC GAAGGCAGCC TTATCCCCAG GAGATGATTG AAAATGTAAG AACTATTCTG AGCCTGCAGG 000400
000401 CCATAGCCAA AGAGGACCTA CTGTTAAGTT TTCAAGACCA CCCAGAAAGA AATTTGAAGT TGGGTTTATA TCCTTAATCC 000480
000481 CTCAGTTAGA AAAAAAAGAA AAGTGAAGAA ACTGCATCTC CAAGATCCTG CTATATCAAC TTCAGTTTTT TGAAGTTAAA 000560
000561 TTTGATTTTT AAATCCCTTG GCTGATGAGA CCTGTGTGGG TTTTTTTTTG TTGTTTTTTT GTTTTGTTTT GTTTTGTTTT 000640
000641 ATCATTGTAC CTCTATTTTA AAAATAGAGA CTTGTGGTTC TTTTTCCAAA AGCAGTCCAA CAGAAAGTGA ATGGTGGTCA 000720
000721 ATGCATAATA AAATGAGAGT TACCTTTTGA
Labs working on this lncRNA
- Department of Oncology, The Fifth Hospital of Wuhan.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Tong W, Yang L, Yu Q, Yao J, He A. A new tumor suppressor lncRNA RP11-190D6.2 inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells. Onco Targets Ther. 2017 Feb 27;10:1227-1235. doi: 10.2147/OTT.S125185. eCollection 2017.
- ↑ 2.0 2.1 2.2 Qu G, Ma Z, Tong W, Yang J. LncRNA WWOX‑AS1 inhibits the proliferation, migration and invasion of osteosarcoma cells. Mol Med Rep. 2018 Jul;18(1):779-788. doi: 10.3892/mmr.2018.9058.
