SMILR

Annotated Information

Approved Symbol

SMILR: smooth muscle induced lncRNA, enhancer of proliferation

RP11-94a24.1

Chromosome

8q24.13

RefSeq(supplied by NCBI)

NR_131202

Characteristics

SMILR is located ~750 kbp downstream of HAS2 on the same (reverse) strand and ~350 kbp from ZHX2 and ~750 kbp from HAS2-AS1 on the opposite strand of chromosome 8 . The longest open reading frame(ORF) within SMILR is 57 amino acids .

Localization of SMILR.(A)RNA FISH analysis of SMILR,cytoplasmic UBC mRNA,and nuclear SNORD3 RNA in HSVSMC.(B)25±5 individual SMILR molecules were observed within the nucleus and cytoplasm. .

Cellular Localization

SMILR is located in both nucleus and cytoplasm .

Expression

SMILR is expressed highest in heart . It is differentially expressed in human saphenous vein-derived smooth muscle cells following stimulation with interleukin-1α and platelet-derived growth factor . ​Increased expression of SMILR is observed in unstable atherosclerotic plaques, and plasma from patients with high plasma C-reactive protein .

Function

SMILR acts as a driver of vascular smooth muscle cell proliferation . Knockdown of SMILR markedly reduced cell proliferation and HAS2 expression was also reduced by SMILR knockdown .

Regulation

SMILR expression can be regulated by IL1α or PDGF and it is a time-dependent manner .

Labs working on this lncRNA

• BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
• British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, Edinburgh, United Kingdom