MYOSLID
Contents
Annotated Information
Approved Symbol
MYOSLID ("myocardin-induced smooth muscle lncRNA, inducer of differentiation")
Chromosome
2q33.3
RefSeq(supplied by NCBI)
XR_923811
Characteristics
MYOSLID is located in a lncRNA-rich genomic region of chromosome 2 where the closest protein coding genes are 70 kb (KLF7) and 200 kb (CREB1) away from its 5’end and 3’ end, respectively.[1] It is a VSMC-selective lncRNA, which is a direct transcriptional target of MYOCD/SRF and TGFβ/SMAD pathways.[1] MYOSLID transcripts are predominately localized in the cytosol.[1]
Function
MYOSLID is a new member of the SRF-dependent program of human VSMC differentiation and it can be directly targeted by MYOCD/SRF. Under pathological conditions, MYOSLID is reduced.[1] MYOSLID promotes F-actin assembly leading to MKL1 nuclear translocation and the subsequent transcriptional activation of downstream VSMC contractile genes.[1]
Labs working on this lncRNA
- From the Department of Molecular and Cellular Physiology (J.Z., W.Z., W.W., E.T., M.X., A.R., D.J., H.A.S., X.L.), Albany Medical College, NY; Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ (A.A.); Departments of Genetics (M.L., D.Z.) and Neurology and Neuroscience (D.Z.), Albert Einstein College of Medicine, Bronx, NY; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (P.J., J.M.M.); and National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, P.R. China (M.X.).[1]
- From the Department of Molecular and Cellular Physiology (J.Z., W.Z., W.W., E.T., M.X., A.R., D.J., H.A.S., X.L.), Albany Medical College, NY; Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ (A.A.); Departments of Genetics (M.L., D.Z.) and Neurology and Neuroscience (D.Z.), Albert Einstein College of Medicine, Bronx, NY; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (P.J., J.M.M.); and National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, P.R. China (M.X.). longx@mail.amc.edu.[1]
