FOXP4-AS1

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Annotated Information

Name

FOXP4-AS1:FOXP4 antisense RNA 1

Characteristics

The FOXP4-AS1 gene is located at the chromosomal locus 6p21.1 and encodes a 588 bp transcript.[1]

Cellular Localization

Function

Effect of FOXP4-AS1 on CRC cell cycle progression and apoptosis in vitro[1].

FOXP4-AS1 overexpression is positively correlated with advanced pathological stages and larger tumour sizes in patients with CRC(colorectal cancer). FOXP4-AS1 knockdown can significantly inhibit cell viability all in five CRC cell lines, increase the percentage of cells in G0/G1 phase and decrease the percentage of cells in S and G2/M phase compared to control cells compared with control cells. as a result, FOXP4-AS1 promotes CRC cell proliferation by promoting cell cycle progression. In addition, FOXP4-AS1 knockdown can also induce CRC cell apoptosis and inhibits CRC cell tumourigenesis in vivo.[1]

Expression

The expression of Foxp4-as1[1].

The expression of FOXP4-AS1 is consistently up-regulated in CRC(colorectal cancer) than in adjacent normal tissues. In addition, BioGPS data set analysis indicates that the FOXP4-AS1 gene is not expressed in normal human colorectal tissues[1]

Diseases

Colorectal cancer [1]

Sequence

>NR_126415.1 Homo sapiens FOXP4 antisense RNA 1 (FOXP4-AS1), transcript variant 1, long non-coding RNA

000001 CCCTGGTTTT CTGTGGAAAG TGAGCTTCTG GGTTCGACAG TGGGACCGGC ACAGACCTTC CCGCAGCTAC AGGCCATACG 000080
000081 ACAACCCCGC TGCTCTTTCT TTCTGCGGGC ACTCGGGCCA GTCCTAACAA TTGCCCCTCA AGCTGTGTGT GCTGCCCTAA 000160
000161 CCCTCAATCC CGAACCCGAA ACAGTGCGTG CTGGGACGAA TCTAGGCAGG TCTCCGAAAC CGGGGTGAAG ATGCTGAAGT 000240
000241 TCAGGTCATT CCGGACTCCT GACGCCGCCA GTCCCGCGGT GAGACGTGAG CGCCATTGGC GTCCGTGGCC TCTGTTTCCG 000320
000321 TGGCAACCTA GTAACCATTA ATTTTCAATT AAAGGAGACA AAAAGCTCGA TGACAGCTCC AGGTCTGCTG AAGATGTCAA 000400
000401 GAATCTGTAT TAATATACAG CAAGAGAGCA TAATTGTGTG TCCATCTTCC AGAGCAGCGA AAAATGGAGG GATAATTACC 000480
000481 AGCTCGAAAG CCACTCTGTA ATTTAGTTCT TACTGTCACC ACAGCCCTAC ACATTAGCAT AAATTAAAAG CAGAGTTTAT 000560
000561 TGTTATCAAA GTGCAAAAAA AAAAAAAA

Labs working on this lncRNA

  • The Second Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Li J, Lian Y, Yan C, Cai Z, Ding J, Ma Z, Peng P, Wang K. Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer. Cell Prolif. 2017 Feb;50(1).
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