BOK-AS1

From LncRNAWiki
Revision as of 14:42, 8 December 2017 by Lin Liu (talk | contribs)
Jump to: navigation, search

Annotated Information

Approved Symbol

BOK-AS1 (BOK antisense RNA 1)

Previous Symbols

BOKAS

Schematic representation of genomic organization of BOKAS in the relation with hBok [1].
v

Synonyms

"NCRNA00151, NAToB"

Chromosome

2q37.3

RefSeq ID

NR_033346

Ensembl ID

ENSG00000234235

Characteristics

The BOK-AS1 gene consists of 2 exons and it is a natural antisense transcript of the hBok gene.[1] The full-length BOK-AS1 transcript has 855 nucleotides but does not contain a long open reading frame, giving 79 amino acids in conceptually translation.[1]

Function

BOK-AS1 function specifically in the human testis, where it serves as an antisense molecule to regulate Bok-induced apoptosis.[1] Overexpression of BOK-AS1 reduced Bok-induced cell death. To assess the effect of BOK-AS1 on Bok-induced apoptosis, overexpressed ectopically BOK-AS1 in HeLa cells showed expression of BOK-AS1 alone exhibited no significant anti- or pro-apoptotic activity when compared with control plasmids.[1]

Expression

BOK-AS1 mRNA is differentially expressed in human tissues.[1] The mRNA expression of BOK-AS1 is only detected in testis and certain cancer tissues but not in other normal adult tissues examined.[1]

Experiment Forward primer Reverse primer
Quantitative PCR 5'-GTTCTGGCTTCAGGATCTGC-3' 5'-TCCAAAATAGGCCTCAGTGG-3'[1]

Sequence

>gi|289629233|ref|NR_033346.1| Homo sapiens BOK antisense RNA 1 (BOK-AS1), antisense RNA

000001 CCCCACGGCG ACTGCCAGGA CCCGGCCCTC CCCGCCCCGG CCCGGGGCCG CCCACCTCCG CCGCTGGCGT CCTGCGCGCG 000080
000081 TGTCCCCGGC CTCGCCGTTC CCGTGGCACC CCGGGCACCC CGGCACGGAC GCCACGCCCG CCGCGCTCAC CTCTCCCGCC 000160
000161 GCATGGCGCG GGCGCCGGGG TGGAGTTCTG GCTTCAGGAT CTGCTCGCCG CCGACGACGA CCTCGACCCT TCCATTCAGA 000240
000241 CCCGCGAGGA CGCGCGCCCC GCCCCGGCGC CCGCCCCGTC CACGCCCGAG CCGGGAGCGC CAGGTCCACG GGGCTTCCCG 000320
000321 CGCTCTTGGG GGGCTCCTGC CGCGGCGTCG GGGGCCTGGG CAGCGAGGGC CTCCAGAGGA ACCAGCGCTG CCGACTCCTT 000400
000401 GATTCTAACC CACTGAGGCC TATTTTGGAT TTCTGCACCC CAGAACTGTG GGAGAGTAAA TTGTGCTGTT GAAGCCACCA 000480
000481 CATTTGTGGT GATCTGTTCC AGCTGCAGTA GGAAGCTCGT ATGCTTGGCA GTTCTGATTG TGAACTCACC TTTATGTTGG 000560
000561 AGATTCCTTT ACACATAAGT CCCCTTATCC ACAGCGGACA AATTCCATGA CCCCCAGTGG ATGCCTGAAA TCGCGGAGAG 000640
000641 TACTGAATCC TACATATAAT GTGTTCTTTC CTATATGTAT ATGTATATAT CTATATCTAT GATACAGTCT AATTTATAAA 000720
000721 TTAGGCACAG TGAGAGATTA ACAACAATAA CTAATAGTAA AATAGGACAA TGATGACAAT ATAATGTAAT AAAAGTTTTG 000800
000801 TGAATATGGT CTCTCTTCTC TCTCAAAAAA AAAAAAAAAA AAAAAAAAA

Labs working on this lncRNA

  • University Women's Hospital Basel and Research Department of University Hospital, CH-4031 Basel, Switzerland.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Zhang H, Gao S, De Geyter C. A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. Int J Oncol. 2009 Apr;34(4):1135-8.
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=BOK-AS1&oldid=1273998"