HOXA13
HOXA13, the most distal member of the HOXA gene with a prognosis role of in human solid tumors
Contents
Annotation Information
Approved Symbol
HOXA13
Approved Name
HOXA13: homeobox A13
Characteristics
HOXA13 is the most distal member of the HOXA genes, is located on chromosome7. [1] HOXA13 belongs to The homeobox (HOX) genes which are an evolutionarily highly conserved gene family of homeodomain-containing transcription factors, which play critical roles in regulating embryonic development. [2] HOXA13 is a marker of gut primordia posteriorization during development, plays a crucial role in extra-embryonic vascularization and is involved in leukemogenesis. [3]
Function
In the developing limb, HOXA13 localizes to discrete domains within the interdigital and interarticular regions, where its function is required for interdigital programmed cell death (IPCD), digit outgrowth and chondrogenesis [4][5] HOXA13 plays major role in development of HCC. [3] A plenty of studies showed that elevated HOXA13 expression in tumor tissue was correlated with poor survival of patients with various solid tumors [1]
Regulation
Primary human fibroblast manipulation via siRNAs directed against HOTTIP RNA resulted in a concomitant reduction of HOXA13 levels [6]
Disease
- Hand-foot-genital syndrome [7]
- Hepatocellular carcinoma [1]
- Preaxial deficiency, postaxial polydactyly, and hypospadias [4]
Expression
HOXA13 overexpression is found in poor OS in human cancer, Histological grade and TNM stage.HOXA13 shows significant overexpression in lymph node metastasis. [1] HOXA13 might be a valuable biomarker of poor prognosis. [1]
Labs working on this lncRNA
- Institute of Pathology, Molecular Pathology Division, University Hospital of Basel, Basel, Switzerland
- Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA
- Research Group Human Genetics, Department of Biomedicine, University of Basel and Division of Medical Genetics, University *Children's Hospital, Basel, Switzerland
- Department of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy
- Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
- Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Wen YA, Shu FP, Chen YD, Chen YW, Lan Y, Duan XL et al. The prognostic value of HOXA13 in solid tumors: A meta-analysis[J]. Clin Chim Acta. 2018, 483(64-68
- ↑ W.J. Gehring, Y. HiromiHomeotic genes and the homeobox Annu. Rev. Genet., 20 (1986), pp. 147-173
- ↑ 3.0 3.1 Quagliata L, Matter MS, Piscuoglio S, Arabi L, Ruiz C, Procino A et al. Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients[J]. Hepatology. 2014, 59(3):911-923.
- ↑ 4.0 4.1 Stadler, H. S., Higgins, K. M. and Capecchi, M. R. (2001). Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development 128,4177 -4188
- ↑ Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H.,Birling, C., Dierich, A., Dolle, P. and Chambon, P. (1996a). Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development 122,461 -472
- ↑ Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression[J]. Nature. 2011, 472(7341):120-U158.
- ↑ Verp MS. Urinary-Tract Abnormalities in Hand-Foot-Genital Syndrome[J]. Am J Med Genet. 1989, 32(4):555-555.
Sequence
>gi|3209|ref|NM_000522.4| Homo sapiens homeobox A13 (HOXA13), mRNA
000081 TTTCTCTACG ACAACGGCGG CGGCCTGGTG GCCGACGAGC TCAACAAGAA CATGGAAGGG GCGGCGGCGG CTGCAGCAGC 000160
000161 GGCTGCAGCG GCGGCGGCTG CCGGGGCCGG GGGCGGGGGC TTCCCCCACC CGGCGGCTGC GGCGGCAGGG GGCAACTTCT 000240
000241 CGGTGGCGGC GGCGGCCGCG GCTGCGGCGG CGGCCGCGGC CAACCAGTGC CGCAACCTGA TGGCGCACCC GGCGCCCTTG 000320
000321 GCGCCAGGAG CCGCGTCCGC CTACAGCAGC GCCCCCGGGG AGGCGCCCCC GTCGGCTGCC GCCGCTGCTG CCGCGGCTGC 000400
000401 CGCTGCAGCC GCCGCCGCCG CCGCCGCGTC GTCCTCGGGA GGTCCCGGCC CGGCGGGCCC GGCGGGCGCA GAGGCCGCCA 000480
000481 AGCAATGCAG CCCCTGCTCG GCAGCGGCGC AGAGCTCGTC GGGGCCCGCG GCGCTGCCCT ATGGCTACTT CGGCAGCGGC 000560
000561 TACTACCCGT GCGCCCGCAT GGGCCCGCAC CCCAACGCCA TCAAGTCGTG CGCGCAGCCC GCCTCGGCCG CCGCCGCCGC 000640
000641 CGCCTTCGCG GACAAGTACA TGGATACCGC CGGCCCAGCT GCCGAGGAGT TCAGCTCCCG CGCTAAGGAG TTCGCCTTCT 000720
000721 ACCACCAGGG CTACGCAGCC GGGCCTTACC ACCACCATCA GCCCATGCCT GGCTACCTGG ATATGCCAGT GGTGCCGGGC 000800
000801 CTCGGGGGCC CCGGCGAGTC GCGCCACGAA CCCTTGGGTC TTCCCATGGA AAGCTACCAG CCCTGGGCGC TGCCCAACGG 000880
000881 CTGGAACGGC CAAATGTACT GCCCCAAAGA GCAGGCGCAG CCTCCCCACC TCTGGAAGTC CACTCTGCCC GACGTGGTCT 000960
000961 CCCATCCCTC GGATGCCAGC TCCTATAGGA GGGGGAGAAA GAAGCGCGTG CCTTATACCA AGGTGCAATT AAAAGAACTT 001040
001041 GAACGGGAAT ACGCCACGAA TAAATTCATT ACTAAGGACA AACGGAGGCG GATATCAGCC ACGACGAATC TCTCTGAGCG 001120
001121 GCAGGTCACA ATCTGGTTCC AGAACAGGAG GGTTAAAGAG AAAAAAGTCA TCAACAAACT GAAAACCACT AGTTAATGGA 001200
001201 TTAAAAATAG AGCAAGAAGG CAACTTGAAG AAACGCTTCA GAACTCGTTG CTTTGCCCAG ATAATGATAA TAATGCTTAA 001280
001281 TAATAATTGA AGAATGGGAA AGAGAAAGAG ACAGAGACTG GCATTTTCCT CTCCCGAAGG AGATCTCTTT CTCTTTAATG 001360
001361 GAATCTACAA CTGTTTTAAA ACTTTAAGAA AGGTAAAGAC TGCCAGTTCT TCCGCCAACC CCATCAGCCC AGCCCGTTAA 001440
001441 ATGTCAAACG TCAACCCCCA AAATACGCAA TTTCAGATAA GTTACGCAGT TACTGAAATC TTGTAAGTAT TTAAGTGATC 001520
001521 GTTACATTTT AGGACACTGC GTTAGATGGT AATAATCTGG AAGTTGGTTA CAAACGCAAG AGGCCATTGT AAACATCTGC 001600
001601 TTGTCCTTCT TAGGTCGCCA TTCCCTTTGC ATGTTAAGCG TCTGCTCAGG TAAATCTTAG TGAAATTCCT ACCGTTGTTG 001680
001681 TACGTTCTGC AAAACATTTT ATGTATAGAT TTAGAGGGGA AACGAGAAGG TACTGAAATA ATGATCTTGG AATATTTGCT 001760
001761 GTGAAGGGAG AAAGGGAGAG AAAACTCTTC TGAGGATCAT TTGTCTTGGT AGTATAGTAA AACCAACCAG CTGAACCTTT 001840
001841 CAGGCTACAA GAGAACCCGG GTCGGTAATG TCTTTTTAAG AATAATTTTT AATTGCTTAT AACAAGCATA TTTTGTGGCA 001920
001921 TTTGAACTAT ATTTACTGCT CCAATATCCG TTATTTTCCA AAGGATTTTG TATCTTTTTG AAAATGTTTA CATCATCAGA 002000
002001 TGATCCACAG AATTCACTTT ATGTGAGATC TCCCGAGAGT TTCCATCCCA ACATGATGGA CTTTGGTTTG AACACAATTC 002080
002081 GTTTTTTCAT TTGAATTGGC ATTTCCCAAT ATTTGCTAAA CATTTGCTGG AGAAATCATT TTTCTTTTTT CTTTTTTAGA 002160
002161 AAACTCAGAA TGAAAATTCA TTCCCCTGAA ATATTTAGGT GTCTATATTC TATATTTTGA TCTATTAAGG GATTAGTATT 002240
002241 TTTCCATGTT TATTGTGTTA TCAGAGTGCA TTAGAAAGAT TAGTGATTCA TCTTCACAGC ACATTTTTAA TCAAGCAGTT 002320
002321 ATTTCAACCA GCACATTCGT TTTGTTCATA TTCACTATAG AATGATATCT TGTAAATAAA GACATTCAGC ACACTGTGAA 002400
002401 AATGTATTTG TGCACCTGCT TTTTAAATAT TTCTACTAAA AATGAAAAAA AAAAACCCTT AGACCTGTAG ATAGTGATAT 002480
002481 CGTAATATTA ATTGTTAATA AAATAGTCAC TGCC
