NONHSAT076153

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Annotated Information

Name

PCGEM1: Prostate-specific transcript, LINC00071 (HGNC)

Characteristics

PCGEM1 is located at human chromosome 2q32.3 (HGNC), containg 1603 bp and 3 exons (GenBank).

Function

Over-expression leads to inhibition of apoptosis induced by doxorubicin .

Disease

prostate cancer

Expression

Prostate tissue-specific and prostate cancer-associated (Srikantan 2000). Cholesterols upregulate the expression of PCGEM1 even in androgen-insensitive prostate cancer cell lines while phytosterols reverse this effect (Ifere 2009). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation (Petrovics 2004). Low specificity as a biomarker for prostate cancer (14%) (Bialkowska-Hobrzanska 2006).

Conservation

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Misc

GWAS association with schizophrenia. PCGEM1 polymorphisms may contribute to PCa risk in Chinese men (Xue 2013)

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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Basic Information

Transcript ID	NONHSAT076153
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	1603 nt
Genomic location	chr2+:193614571..193641625
Exon number	3
Exons	193614571..193614754,193615515..193615598,193640304..193641625
Genome context
Sequence	>gi

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