LNCOG
LNCOG, Promotes the Osteogenic Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells
Contents
Annotated Information
Approved Symbol
LNCOG
Approved Name
LNCOG: lncRNA osteogenesis associated, LINC02407, RP11-54A9.1, lncRNA-OG
Characteristics
LNCOG is located on human chromosome 12 between the NAP1L1 and BBS10 genes [1]. LNCOG contains four exons, comprising 878 nucleotides, at a modestly conserved locus according to Phylop analysis [1]. LNCOG is mainly located in the nucleus of BM‐MSCs which indicates that LNCOG may exert its biological function in the nucleus [1].
Function
LNCOG is a functional osteogenesis‐associated lncRNA that significantly promotes BM‐MSC differentiation into osteoblasts by regulating the expression of BMP family proteins via interactions with hnRNPK [1].
Regulation
hnRNPK increases LNCOG promoter H3K27 acetylation to promote LNCOG transcriptional activity [1].
Diseases
- NA
Expression
LNCOG is expressed in the process of BM‐MSC osteogenesis [1].
Labs working on this lncRNA
- Center for Biotherapy, Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University, Guangzhou, People's Republic of China
- Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat‐sen University, Shenzhen, People's Republic of China
References
Sequence
>gi|105369848|ref|NR_146531.1|Homo sapiens lncRNA osteogenesis associated (LNCOG), long non-coding RNA
000081 AAAACAACTG ATGAAAACGA CATGCGTGAC ATTTGGTGCT GAAGACCCAG GTCAGAGAGA CTCCTTTGGG GGACCAGTCC 000160
000161 GCTGTCCTTG CCCTCACTCT GTGAGGAGAC CCACCTACGA CCTCGGGTCC TCAGACCAAC CAGCTCAAGG AACATCTCAC 000240
000241 CAATTTCAAA TCGGGACCCC ACTGGAAAAT GGACTGTCCA ACTCACCCGG CAGCCACTCC CAGAGCCCCT GGAACTCTGG 000320
000321 CCCAAGGCTC TCTGACTGAC TCCTTCCCAG ATCTTCTCGG CTCAGCAGCT GAAGACTGAC ACTGCTTGAT TGCCTGGGAA 000400
000401 GCCTATAGGA CCATCACAGA CACTTTGGAT AACTCTTACA GTGAAGGACA AAAAAGCGCC ACTGCAGGGA GGAATGCCAG 000480
000481 GGTCCCATAG AGGGAGACCG ACAGTGAAGT GGAGCCTGCC ATGAATTCAC CAAAGGCCAT TCTCCCTTTC TTCCAGAAGA 000560
000561 ACAGCATTTA GCTGGGCCTA TGGCTACCTA CCTAAAGACT GCACCTCTTA GTCACCCTTG TGGCCAGGTG TGGCCACGTG 000640
000641 ACAGTGGAAT GTAAGTGGAA GTGATGTATG CACTTGGGTT CATTGGTTTA AAAAAAAATA TGACCGCCCT CCATTTCCAC 000720
000721 TCTTTGTCTT ATCTGTGAAT GGGAACATGG CTGTGTCTGC AGCCCGACTT TGTGCAGCAA AGGACAAGGC CCTAGGGGAA 000800
000801 GGTGGAGAAA CAAGATGGAA CAACTTGGAC CCAACAACTT GGATCCCTAT GTGGCCATGT GGAGTCATCT CACCCACCTG 000880
000881 GGCCACTCAC CCCGAAGACT GTTGTGTGAG GGTGAAATAA ACTTCTGTAT CACTAGCCCC TGCATTTCAG AAATTCTTTG 000960
000961 TTATGGCAGT TTTGCCTTTA TCCTAACACA GACAGCAAAG TATCTTCTGT GGCCCCATGA CTAATTTCGT TGTTTAAACT 001040
001041 CATTATAAAA ACTATATAAA TAAAATATTA AAAATCAAAT AAAATAGCAA GATAACACTG TGTAACTATC CAGTTTTAGA 001120
001121 TGTTATTACC TTTTTGGCAT ATTTACCTCA TCTATTTTCT CCAGGGGTTT TTAAAGAAGA GTCATGCTTG TTATTTTAAA 001200
001201 TTATCTGCAG TGCTCCTTGG TCTTATAAAA CTATGGGTTA TTTCAAACTT CGGTAAATGT CTGATACACA TGAACTTCTT 001280
001281 GCATTGTTGA GGAAATCAGA GAAAAATGAT GCTGTTTTTC CCTTGTAAGT TGACAATGGA TGGAGATGAA ACCACCTTTG 001360
001361 CAAAATTATG GCAATAAGAG AAATTGGACA TGGCAGACTC CATCTTGCTT TTAGCCTCAC AGGTTGGCTG TCTTGGCTCA 001440
001441 TTCCTGGGCA TAAGCCAAGC TAACTTTGGC AGAAATTGAG TTTATAGTGT AAACGATAAT AGCCTTTCCC CAAAACTAAA 001520
001521 CTACCCTTGT AAAATTAATG AAAGGCCACC AAGTTAGGAG GATGAGAAGG GCCTGAATGC CTGAATTCAG CCATTATTCT 001600
001601 GGAAGTCACA AGATGTGCAA CCTCCCCAGT TACTCCTGTA AATAACTTCA GTATTGTAGA ACCTAAGATT GGCCTTTTGA 001680
001681 CAGCCTTTTG CATTTCTGAC AACTAGATGG CCCCACGCAG ACCCGTGACT CAACCAGTCC TATAGCCTTC ATCCAAAAAT 001760
001761 GGACTCAGTG CATGAGGACT GTTTTCCACA CCCTTATGAT TGCATCCCAA ACCAATCAGC AGCACCCATA CCCTATCCCC 001840
001841 TGCACACCAA ACTATCTTTG AGAAACTCCT AACCTCTGAT TCTTTGGTGA GATTGATTTA AGTAATAACT CTGTCTCCCA 001920
001921 CATGGCGTGG CTGGCGTCGT GTC
