LINC02597

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LINC02597, long intergenic non-protein coding RNA 2597, serves as a noval diagnostic biomarker in postmenopausal osteoporosis (PMOP).

Annotated Information

Name

LINC02597: Long intergenic non-protein coding RNA 2597 (HGNC nomenclature) LOC101929866 [1].

Characteristics

LINC02597 is 5358 bp long non coding RNA that, located on human chromosome 20q13.12 [1].

Function

LOC101929866 involved in the pathogenesis of PMOP by regulating the expression of their nearby and co-expressed DEmRNAs and the pathway of osteoclast differentiation. [1].

LncRNAs have also been shown to regulate gene expression in cis. LOC105376834-ALPL and LOC101929866-SLPI were two DElncRNA-DEmRNA co-expression pairs in PMOP. In addition, ALPL and SLPI were nearby DEmRNAs of LOC105376834 and LOC101929866, respectively. It was hypothesized that LOC105376834 and LOC101929866 may regulate the expression of ALPL and SLPI by a cis-effect, in which the DElncRNAs were also co-expressed with DElncRNAs. [1].

Regulation

NA

Diseases

  • Postmenopausal osteoporosis (PMOP) [1]

Expression

LINC02597 is downregulated in postmenopausal osteoporosis (PMOP) [1].

Labs working on this lncRNA

  • Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China. [1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Fei Q, Bai X, Lin J, Meng H, Yang Y & Guo A. Identification of aberrantly expressed long non-coding RNAs in postmenopausal osteoporosis[J]. International journal of molecular medicine. 2018, 41(6):3537-3550.

Sequence

>gi|101929866|ref|XR_001754620.2| Homo sapiens Long intergenic non-protein coding RNA 2597 (LINC02597), long non-coding RNA

000001 AGTGGCTGGA GATCCCGATC TCATTGGCTT AGAAGGAGTG CACATCTTCC AGCAAGTTCC TGCGGAGACG TAATAGTTTC 000080
000081 CTGATTCCAG CAGAAGGAGC TGAAGCTGGG AATGGCCCCA CCTTGGGATC TGCTGTGGGA TGGAGGCTGG AGAGTCCATC 000160
000161 TTGTTGGCCA AGACAAGTAC ATATCTCCCT GCAAGTCTCA GCACCGAAAG GATAGTTCAA TTACAGCAGG AAGTGTCAGA 000240
000241 GCTGAGACTG GATCCCATCT CGACCTGCTG TGCAACAGAG GTTGGCAAGC CTGTCAGGGA GGCTTAGGAT CTTAGGCTAT 000320
000321 GAGATATGTG TGAGTCTCCC TCTGGGTTGT TGTGTGAGCA GCTCTGAGCT GGGACCTCAG CTGATGGGGG CTGGAGCTGA 000400
000401 ATCACAAGGC AACTTTCAGA TTCACTGCCC AGTCAGTGAG CAGAAGGGCC TTTCTGCCAA AGCCCTAGTG TATGTGATTC 000480
000481 ATTCTGGACC CCACAGCAGA TGGGTTTGAT TGCAGGCTCA AGGCCAAATG TAACCAAACC CCTGAATGGG CCATTTCTGG 000560
000561 GATTGAACTC TGGAGCCAGC TCAGTGGATC AGCCACGTGG GTGTTGGTCT GCACTCTCAA TATGACCCTC CAAGGTCTTG 000640
000641 GGCTCCACCA GAGTTTCACA AACTTCCCCC TGAATCCAGA TCCAGAGGCT CCCACAGAGA GACTTTGGAC TGTGGATGAG 000720
000721 TGTAGAATTC TTGTCATTCT GGTGGGACAT GAGCAGGTGC CTTCTATTTC ACCATCTTGG TTATGTCATT CCTTCCTCAG 000800
000801 CAGTTTTTTT GGTCGATTTT GCAAAGCTTT AAGTTTTACA GTGGGGCTGG AAATAGCAGG AGAGTGTGAG TTCCAGCCCT 000880
000881 GGGATTTGTT GTTTGCTCCC TTTTCACTGA CAGGTATTTT GTATTTTTGG CATTCTTTGT TTTCAAGTTA TGTTGAGGAT 000960
000961 GTGGTTTTGT TTAGAAATTT CTTGGTGGTG GTGTTATTTT ATACCTCTTG GGGTGGAGAT TGTGGAAGTT ACTTATTCTT 001040
001041 CCTCTTCTGC CTTCTATTGT CTTCAACTAC CCCAAAAAAA TCTCCTGGAA ACTACTCTCT GAAAGAAGTT GGAGAAAAAT 001120
001121 TATTAATGCA CTTGAAGAAG ATCAAGAAAA AAGAAAGCGT GAGTAATGTT TTGGGATCAT CAATATCACT GTCTTCCACC 001200
001201 TCTACATCTT GCCACACTGG AAGGTCTTCG GGAGCAATAA CACATACAGT TGTCACCTCC GGTTATAACA ATGACTTCCT 001280
001281 CTGGAATACA GACTGAAGAA ACTGCCTGGG ACTGTTTTAC AGTTGAGTTA TTTTTTAATA AGTAGAGGAT GGACACTATA 001360
001361 ATAATGATAA AAAGTATAGT ATAGTAATTA TAGTAACATA GTCGTTTACT ATCATTCTGA AGTATTATGT ACTGTGCATG 001440
001441 ATTGCATGCT ATATGTTTAT ATGACTGGCA GTGGAGTACA CTTGTTTACT CCAGCATCAC CTCAAACATG TGAGTAGTGC 001520
001521 CTTGTACTGT GACATTACCA CAGCTATGAC ATTACTAAGT GATAGGAATT TTTCAGCTCC ATTATAGTTT TATGAGAGCA 001600
001601 CCATCACATA TGCGGTTCGT TGCTGACCAA AACATTGCCT CATGCTGGAG AAGAGTATCC GAGCATAGTT GCTGCTTCGA 001680
001681 GTCACTCCAG GGAGATCTAA AATTCCAGGT GAACCATTTG CTGCTATAGT CAAGATGAAA AGGAGTGAAG AACAGCTAAA 001760
001761 TAAAATCAAG TATAATGGAG GGAATCACCA CCAAAAGAGG GAAAAAAGAA AGCCCTGAGA CTCCTTTGTA GACCAGGTTC 001840
001841 CTTTCTCACC TCCTGGCTGC TGTGCTGACC CCCAAGGTCC TGAGGATGAG GAGGCTGAGC AAGGGACAAG GCCACTGGTT 001920
001921 GTCATCTGTC TGGGCATTGG GTGTGACCTC ACAAGGCAAC TTGCATTCTT AACTCTGTCT CAGCCCCTGA GAACCCTGAG 002000
002001 CTTGTTGGAT AACCCAACCT GCAAAACACA GCTCACAGAT TTCTGAGAAG CCTGAAGATT CAGGATCAGG ACCATAGTAA 002080
002081 GATATGAGTG TCTAGGTAGC ATGACAACAG CCAGAACCAC TTCTCAACAA TTGTGTGATG TGTACACAGC TGCTGCAGTC 002160
002161 CTGGACACTC ATCACTGCCA CCCATGACTC TGGAATTGGG TATTGCTGTG GACAACAATA CTACTTTGTT CTGGGAAAGA 002240
002241 ATGCCCCTTC ATCCTTGCTT CTTTGAGTCA CTCAATGGAG ATTCAAGGTG ACATATGGGA ACATTACATT TGCTGAGCAT 002320
002321 GTTTGTGCAG CCCTAGGCCT CAGGGGTGAA GGAAAGTGCC CCCTGTTTTG TTCTGTTTTT GCAGTAGGAA CCCAGCTCTG 002400
002401 TCACTCAGCA AGTCTCAAAG ATGGCCTTAA ATAGGGAGAT CCCACAACAT AACAAGGGAG TTCCACATAG TGGACAGTCA 002480
002481 AAAGCATGGA CACATCTCCC ATACCGTGGA TCTTCCTAGG GTTCCAAACT CCCCTTGAAA CTTACACATT GGCAGGTATA 002560
002561 AAGTGAACAG CACAATTGTT CACCTCTGGA AATAGAAGGG CCACTCCCTA ATCACCATGG AAATATTCCT AAGAATGTGC 002640
002641 CTTTTCTTAT TGGGCAGAAG GCCAGATATC TTTTTTTATC AGTTTTTTCA ATGGCAGTAA TTTATTTCAC AAGGTCACCT 002720
002721 TTAATGGGCC TGACCCATTT TTCTGCCTAT ATTTTAATCA CAGGCTGTAT CTTCAGCTTC TCCACACTAG ATGATACCTT 002800
002801 ATCCTCCCAG CCTACTGTTC AGTGTTTTTA TGGGCACGCT CATTCCTCAA CAATACTGGT CCCACAGTAT TTTTCTCTCC 002880
002881 AATCACAACA GAGCATACCA CTGCTGCCTC CAGGCATGGC AACACCATGT CTGGCCACCA ACATTGCCAA ATTGGACACC 002960
002961 ACTTCCACTC TCCTCACTGG AAATAGATGC TGTAGCCATT TATGCCACTG CTGCCGGAGT AAACTCTCAC TTCCTACCAC 003040
003041 CTCCATGTCT GCTTTTTTCT ATCACCAATT CTCAGTCCAT TGCAGTGTAT ACCTCTGACT GTGTGAACCG GTGCATATGC 003120
003121 ACATGTGGAG GCTGCCAAGA AGTCAGAGAA ACAGGCATGT GGACTTTGCA GCTTCTGCTG GGAATGGTGT TTGTAGGCTT 003200
003201 AGAGGCTAAG ACAGGAAAGT TGCCCACACA ACCATTCTCA TCCCATTGTG AGCACTGGAG CACCTACTAT GCCCCTCCTT 003280
003281 TCCTTCACTC TGTGTTCTAG CCTCAGCTTA TGACCTACAG TTTTAATCAA CTGTAAAAAG GCAATGGAGA TTGGCAATAG 003360
003361 TAGGGACTTC ACCGCCTCTT GCCTGGATTC TCTAATCCAC TTACTTCCTT GAAAAGGCAT TTACAATTCT GTAATCATGA 003440
003441 GGGGAGATCA AGAATTATGA GAAAGATGAG AAGTTCAGGG GCTGCATGAT ATTACTGAAA TTACACAGAG ACTCTAAAAT 003520
003521 GGTAAATCAA TGCTCAGAAT TTGCATTGCA GTCAGAAAAG ATATGGTTAT TCTGGGATAG CTCCACTGCT ACCATGTTCC 003600
003601 TCCTAGAGGC ACAATGTTCT CTAACAAAAC AGTTTTTGCT GAGACTGGAA ACACTGATAA CATATTTGCA GGCTGTGTGT 003680
003681 GCTCCATGGG GGTTGAAAGC GGGGATCACT AATGATAATT TTTGAACAAC CTTCTTAGGC CTTCCTTGTC CAGTACCTCC 003760
003761 TGGGATGGGG ACACTCTGTT CTAGCTAGCC ATGTGTGTCT GTCTTTTGGA GTCCAGAGTG ATAAGCGTCA TGCACAAGTA 003840
003841 CCAGGTGCTT CTCAGCTTGT AACAGATTCC AACTTTTCTT GAATTTGAAG TTGGAAACTC CCTTTGAAAT ATCCAGACAA 003920
003921 AACCCCCCAT CTTGTGGATG GGAAAACCGG AATCCAGGGA TCCATCAAAG TTTAATCTAG AAATCAGGGG CAGAGCTGGG 004000
004001 GCTGGGAACT ATCTGTTCTA ATATGATGTC ATTCCCTTTG GTAGAATGTT GAAAAAGCAG GAGGATTCAT TAGCCTTTCA 004080
004081 AAAAAGACTA GTTGAGGGGT TAATTTGCCA AAAAGCACAG TGACAATAGG AATTCCAGGA AAATAGAATA ATCCAAGCCA 004160
004161 AAATGTGGAA TCAAAGAAAA ATATAGATTT GAGGAGACCC CAAAGAAGTC AGCAACTCAA CTATAAAGTA ACCCTCCACA 004240
004241 ATATGCTAAT TCTGCCACCA TCCAGGTCTT CCGCATCACC TTGGTGTTCT CACTTGCGGT GTGCCCACTG CACGAGCTTT 004320
004321 CTGCTATTCT ACTGCACATT CACAGCTCAC TTGGAAGAAA CTTTAGTAAG ATTCTTGGAA TCTTTCTCAC AGCAGGAAGA 004400
004401 GTCCTAAGAG ACCGAGCTAC TCCTTTTACA ATAATTGAGA CACAGACCGC TGGCAAATGA AATTTGCCCC AAATTTGGAA 004480
004481 GACCATCTCA TAGGCATGAC AACAAAAGAC TCATGTGTTT GTTTTAACTT GGTGTGGTTT TTTTTAATTA TGGGGGTAGT 004560
004561 TTTATTTATT TTCAAATATG TAGTAGCTAC TTGCATTACT TTTTAATAAA CCACATGTTC ATGGTCTATG TTTATTTTTC 004640
004641 TATGAGAAGA TCTATTTTCC TTATTGTGTT TTAAAAATTC TTTCAATATA TTATAGAATA TCTCTATTCC CACCATATGT 004720
004721 GTTTATACAT TTTAAAAATT TCTGTTTTCT TACTGTATGC ATGATTTTCC CTGTAAAACT TTTTATTTGC TTGTAGTTAA 004800
004801 TGATATTAAT TTACTTCAGA AAATCATTCA CGTGTAAATA TTCTACAAAA CTTGTCTCAT GTTTACTTTG AATACTTTTA 004880
004881 TAGTTCGATC TTTATGTTTA AATCCTTGAC CACCTAAAAC GTACTTTGAA ATAATGGGTG GAGTGGAAAT CCAGTATTTA 004960
004961 CTCCTTGAAT TGCCGGTAAT CAGTCTAAAC ATCATTCGCT GAATTACTAA CATTTCTTAA GTGATGTGGA ATTCTGCCCT 005040
005041 TATCATTTGT AAAATTCTCA AAGGCATTGA GTTTATCTTT TATTCCATTG AGATGTGTGC ATTTTCTCAC CATTAATGTA 005120
005121 TGTTCTAATT ATGTTGACAT ATTTTTGTGA TAATTTTGGT GGAATTAAAA TGTGTCATGG GTAACTCTCC CATGACAATT 005200
005201 TATCATCAAT ATTTTCCTGG AAAACCTCAA ATGCTTACTT TATCAGTTGG TATGTTCAAT TTCATTAATC ATTGGATTTT 005280
005281 TATCTCATGG GCTTCCAACT TACTCTTCAT TGTTTATCAC TAAAACCCAC TAAAATCTCC ATTTTTTTTT TTTTTTTT
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