EPB41L4A-AS1
Revision as of 07:39, 13 August 2019 by Qianpeng Li (talk | contribs)
Contents
Annotated Information
Name
Approved Symbol: EPB41L4A-AS1
Approved Name: EPB41L4A antisense RNA 1
Previous Symbols: C5orf26, NCRNA00219
Synonyms: TIGA1
Chromosome: 5q22.2
RefSeq ID: NR_015370
Ensembl ID: ENSG00000224032
LncBook transcript ID: HSALNT0288958
Pubmed IDs: 9490301, 30796006
Characteristics
-
Function
- EPB41L4A-AS1 could alter glycolysis and glutaminolysis levels of cancer cells. Furthermore, EPB41L4A-AS1 knockdown plus glutaminase inhibitor suppressed tumor progression both in vitro and in vivo. Mechanistically, EPB41L4AAS1 interacted and colocalized with HDAC2 and NPM1 in the nucleolus, controlling HDAC2 occupation and H3k27ac modification levels on VHL and VDAC1 promoter regions and regulating their expression, which affected glycolysis and glutaminolysis[1].
Regulation
EPB41L4A-AS1 expression was transcriptionally regulated by p53 and PGC-1α[1].
Diseases
Human cancers[1].
Expression
EPB41L4A-AS1 expression was downregulated in human cancers[1].
EPB41L4A-AS1 is down-regulated in some human cancers. The low expression of EPB41L4AAS1 was associated with poor survival in several cancer types, including cervix, liver, breast, bladder and other cancers[1].
Evolution
Sequence
>gi|284005302|ref|NR_015370.2| Homo sapiens EPB41L4A antisense RNA 1 (EPB41L4A-AS1), long non-coding RNA
000001 TGTCGGGTCC CAAAATACGT GGTCTAAAGT CCTTTGGGCT CCTGCCGCTG CCAGCACTGA TCATATGCTC TTGACCCTGG 000080
000081 TCGGGTGGGG GGATGTCTGG ATACCTCCTC TGTGGAAAGA ACTGGCCACA CATCCGCAGA GGTGACTCGG GCTGAGAACC 000160
000161 CAGGCTCCTC CTCCCTTTGG TGACACGCCC CTCGGTCCCT CACTGGCACT TCTCCCTCCG GCCACACGGC GGCGTCTCGC 000240
000241 CATAGCGCAG CGGCCGATGG TACAGCCCGC TCCCCCCTCG CGCTCTCGGA CAGTGGGTCC TTCCACTTGT AGAAAAGCAT 000320
000321 TGTGGGACGG AAGCCTGTCC TTTCTTCCTT TTGGTGCGAG CTTGCTGTGG TTTTTGCTCT GGGTCCTCTG GGATGGCGCC 000400
000401 TGGCTGTGGC CGCGTGGTCT CTCACGCAGG GGCGCCGGGC GGGGGAACGC GGCCACCCTG AGTCTGGTGA GTCGACTGCG 000480
000481 GCGGCCTGTG TCCGAAGTGT CCGGGGCCGT GAACAAGGGC AGCGGCCTGG CCTCAGGCCT GCGTTCCCAC GTTTGGAAAC 000560
000561 GGGGAGCTTC GTCGATTTGT GTTTACATCA TCGACTATGC CAGGGAGTTC TCCAGATAAG CCTGGTTTTA TTTTCGTCAG 000640
000641 TGAAAAGGCC TTACCGTATA ACTGACTTTA TGCTTGCCCT GCCCCCGTAT AAAATAACTT AAAAGCAGCG TGCCTGGTTA 000720
000721 CAGCTGTTTC CACGTGCGGT GCTCGTCGGG AGTGATCACC TACCCTACAG GTGGAAGATG GATGCCTGAA GTGTAGACTG 000800
000801 CTGCTAGCTG AATACCATCT GGGAGCATAA AGGTGACCTG AAGGATGTCC TTGGTGAGGA TTTTGAAAAT TTGATCTTCA 000880
000881 CAAGAGTTGC CTGGATCATT TGAAATTTCT GGGAGTCTGA GGAGTACTGA CATAATTACC TGCTGGAGTC TGTAAATACA 000960
000961 CATTTAAGAC AGTGAGGATG TGAATAAATA TATTAATGCA CTTTGGCATT TGTGTTTTAA GTGATTAACT GCCAGAAACA 001040
001041 GCTATTTCTA AAAAGTTATA AGGGAGGAGG GGTTCTTTTT TGATCAGTAT TCACTGCTGT CACCATAATT AATAGCCTTA 001120
001121 AAATAGCTTG TGTTTGGCCC AAAGAGAAAT GTACTTTCTT CCAGTGACTC AAAAATCGTG GCTAGAACTA GACT
000081 TCGGGTGGGG GGATGTCTGG ATACCTCCTC TGTGGAAAGA ACTGGCCACA CATCCGCAGA GGTGACTCGG GCTGAGAACC 000160
000161 CAGGCTCCTC CTCCCTTTGG TGACACGCCC CTCGGTCCCT CACTGGCACT TCTCCCTCCG GCCACACGGC GGCGTCTCGC 000240
000241 CATAGCGCAG CGGCCGATGG TACAGCCCGC TCCCCCCTCG CGCTCTCGGA CAGTGGGTCC TTCCACTTGT AGAAAAGCAT 000320
000321 TGTGGGACGG AAGCCTGTCC TTTCTTCCTT TTGGTGCGAG CTTGCTGTGG TTTTTGCTCT GGGTCCTCTG GGATGGCGCC 000400
000401 TGGCTGTGGC CGCGTGGTCT CTCACGCAGG GGCGCCGGGC GGGGGAACGC GGCCACCCTG AGTCTGGTGA GTCGACTGCG 000480
000481 GCGGCCTGTG TCCGAAGTGT CCGGGGCCGT GAACAAGGGC AGCGGCCTGG CCTCAGGCCT GCGTTCCCAC GTTTGGAAAC 000560
000561 GGGGAGCTTC GTCGATTTGT GTTTACATCA TCGACTATGC CAGGGAGTTC TCCAGATAAG CCTGGTTTTA TTTTCGTCAG 000640
000641 TGAAAAGGCC TTACCGTATA ACTGACTTTA TGCTTGCCCT GCCCCCGTAT AAAATAACTT AAAAGCAGCG TGCCTGGTTA 000720
000721 CAGCTGTTTC CACGTGCGGT GCTCGTCGGG AGTGATCACC TACCCTACAG GTGGAAGATG GATGCCTGAA GTGTAGACTG 000800
000801 CTGCTAGCTG AATACCATCT GGGAGCATAA AGGTGACCTG AAGGATGTCC TTGGTGAGGA TTTTGAAAAT TTGATCTTCA 000880
000881 CAAGAGTTGC CTGGATCATT TGAAATTTCT GGGAGTCTGA GGAGTACTGA CATAATTACC TGCTGGAGTC TGTAAATACA 000960
000961 CATTTAAGAC AGTGAGGATG TGAATAAATA TATTAATGCA CTTTGGCATT TGTGTTTTAA GTGATTAACT GCCAGAAACA 001040
001041 GCTATTTCTA AAAAGTTATA AGGGAGGAGG GGTTCTTTTT TGATCAGTAT TCACTGCTGT CACCATAATT AATAGCCTTA 001120
001121 AAATAGCTTG TGTTTGGCCC AAAGAGAAAT GTACTTTCTT CCAGTGACTC AAAAATCGTG GCTAGAACTA GACT
Labs working on this lncRNA
- School of Life Sciences, Tsinghua University, Beijing 100084, PR China
