LINC00441
Contents
Annotated Information
Name
Approved Symbol: LINC00441
Approved Name: long intergenic non-protein coding RNA 441
Previous Symbols: RB1-DT
Synonyms: ncRNA-RB1
RefSeq ID: NR_046414
Ensembl ID: ENSG00000231473
LncBook ID: HSALNT0289037
Chromosome
13q14.2
Function
Knockdown of LINC00441 in tumor cells reduced expression of CALR, impaired the translocation of the protein to the cell surface upon treatment with anthracylines and consequently inhibited the cellular uptake by macrophages.[1]
Sequence
>gi|379030629|ref|NR_046414.1| Homo sapiens long intergenic non-protein coding RNA 441 (LINC00441), long non-coding RNA
000001 CTGGGGCGCT GGTCGGTGCG CGGGCTGGGA CGCTAAGTCA TGAGGAATTA AACTGGGAAA CCTGGCGTGG GTCCAGGCGC 000080
000081 CTTCCAGGAG GCATCCGGCG CGGCCCGGAC GTGCTTCTAC CCAGAACCAC CCCCTCCAGG CCGGGGTGCA CTTAACGGGG 000160
000161 CTATACAAAG AGTCTGGTGG GTGACTGTGG GCCTCATCCC TATCCCGGGG TCTGATAGGG AAGACTCTCG GGCCCCGCAG 000240
000241 GGAATATCTG GCTAGTGCAC CCTCGGCGGG AGCGCCACTC TCCCTCCTTG GGCGGCGCCC CCCACCTCTC ATCCCGCCCA 000320
000321 ATCCGTTTTG CAAAGTCGGC CAAAACAAAA ACAAACTTGG AGCGCTGATA GACACTGTTA TTGCCCATCT GAACTCGTCA 000400
000401 ACTGAGAAGG AAAGAGATGG TTTATGCTGT GAATAAAATA CAGTTGTGCT GTGATGTAAA TCCCCTCATC CTGGAGCAGC 000480
000481 TGAGCAAGGT CTAAGGCAGG AAGAACCTTC AAGCAGGTCA TGGCTTGCAG GCTCAACTCT GCCTGGCAGT GGCAAGGGCC 000560
000561 AGGGCCAGTG ACTGAAGCAA CAAACTGCCA GATGACTGCA GCTCAAGCCA ATGCACAAAG CCACTGCAAC AAGAGAGGAA 000640
000641 ATTCTTCCAT TTCCAAGTGT GTCGATTTCT CCCCATCAAG GAAAACAGCT AAGGCAATGT GTTGATATTT TCTTTGACCA 000720
000721 AGTCATCAGG AGTCACATAG ACATACAGCA CTCAAGAAGT GGCTGTAACT AAAGGCACAT CTCGTTCATC TACAACCCTT 000800
000801 GTAATCCCAA CCTTTGTCTG ATGCACAAAC CCTTCCCTAG TTCTCCCCAC CACCACCACT GCACCTCCAA GTGGGGACAA 000880
000881 CGAATTGTTT CATTTGCATG TGGTTTTTCT CATGAAAAAT ATCATTAACA TGAGACAGCC CCAAACCAAG GAAACCAGAA 000960
000961 GTGGGGTTTG TGCTTGGTCT TACTGAGAGC TTTCCCTACT TGACCAGACC CCAGCATTGT TCTAGATTTG TCTCTTGTGG 001040
001041 GCTACAGGAA TGCAAACATT TTGTAGTTTC CTCTTTTTTG TTTTCTTAAT GGCTTGATGA GCCACACATG TTTCTCTAAA 001120
001121 TGCATGATTT TAAATTCACA CAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A
000081 CTTCCAGGAG GCATCCGGCG CGGCCCGGAC GTGCTTCTAC CCAGAACCAC CCCCTCCAGG CCGGGGTGCA CTTAACGGGG 000160
000161 CTATACAAAG AGTCTGGTGG GTGACTGTGG GCCTCATCCC TATCCCGGGG TCTGATAGGG AAGACTCTCG GGCCCCGCAG 000240
000241 GGAATATCTG GCTAGTGCAC CCTCGGCGGG AGCGCCACTC TCCCTCCTTG GGCGGCGCCC CCCACCTCTC ATCCCGCCCA 000320
000321 ATCCGTTTTG CAAAGTCGGC CAAAACAAAA ACAAACTTGG AGCGCTGATA GACACTGTTA TTGCCCATCT GAACTCGTCA 000400
000401 ACTGAGAAGG AAAGAGATGG TTTATGCTGT GAATAAAATA CAGTTGTGCT GTGATGTAAA TCCCCTCATC CTGGAGCAGC 000480
000481 TGAGCAAGGT CTAAGGCAGG AAGAACCTTC AAGCAGGTCA TGGCTTGCAG GCTCAACTCT GCCTGGCAGT GGCAAGGGCC 000560
000561 AGGGCCAGTG ACTGAAGCAA CAAACTGCCA GATGACTGCA GCTCAAGCCA ATGCACAAAG CCACTGCAAC AAGAGAGGAA 000640
000641 ATTCTTCCAT TTCCAAGTGT GTCGATTTCT CCCCATCAAG GAAAACAGCT AAGGCAATGT GTTGATATTT TCTTTGACCA 000720
000721 AGTCATCAGG AGTCACATAG ACATACAGCA CTCAAGAAGT GGCTGTAACT AAAGGCACAT CTCGTTCATC TACAACCCTT 000800
000801 GTAATCCCAA CCTTTGTCTG ATGCACAAAC CCTTCCCTAG TTCTCCCCAC CACCACCACT GCACCTCCAA GTGGGGACAA 000880
000881 CGAATTGTTT CATTTGCATG TGGTTTTTCT CATGAAAAAT ATCATTAACA TGAGACAGCC CCAAACCAAG GAAACCAGAA 000960
000961 GTGGGGTTTG TGCTTGGTCT TACTGAGAGC TTTCCCTACT TGACCAGACC CCAGCATTGT TCTAGATTTG TCTCTTGTGG 001040
001041 GCTACAGGAA TGCAAACATT TTGTAGTTTC CTCTTTTTTG TTTTCTTAAT GGCTTGATGA GCCACACATG TTTCTCTAAA 001120
001121 TGCATGATTT TAAATTCACA CAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A
Labs working on this lncRNA
- Noncoding RNA Research Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.
References
- ↑ Musahl AS, Huang X, Rusakiewicz S, Ntini E, Marsico A, Kroemer G, Kepp O, Ørom UA. A long non-coding RNA links calreticulin-mediated immunogenic cell removal to RB1 transcription. Oncogene. 2015 Sep 24;34(39):5046-54. doi: 10.1038/onc.2014.424. Epub 2015 Jan 12. PubMed PMID: 25579178.
Predicted Small Protein
| Name | LINC00441_smProtein_416:493 |
| Length | 25 |
| Molecular weight | 2834.4199 |
| Aromaticity | 0.04 |
| Instability index | 40.696 |
| Isoelectric point | 5.81805419922 |
| Runs | 6 |
| Runs residual | 0.0316981132075 |
| Runs probability | 0.0426455867632 |
| Amino acid sequence | MVYAVNKIQLCCDVNPLILEQLSKV |
| Secondary structure | LEEHHHHHHHHLLLLHHHHHHHLLL |
| PRMN | - |
| PiMo | - |
