LUADT1
Contents
Annotated Information
Approved Symbol
LUADT1
Approved Name
lung adenocarcinoma associated transcript 1
Chromosome
6q24.3
RefSeq ID
NR_132442
Ensembl ID
ENSG00000196634
Sequence
>gi|921274084|ref|NR_132442.1| Homo sapiens lung adenocarcinoma associated transcript 1 (LUADT1), long non-coding RNA
000001 GCAGAAATGG TTTCCGTTCA GCAAATCCAC ACCAGCAATC CTCTTACAGC AAATTTCCAA GAAACATGGT TGGATAACAG 000080
000081 TGCTGGACCT AAAAAAGGTG TTGGCCCACG AGTGCCTCTC TCTCCCTGCC TGAGCTCCCT GACCAGCATG CGTGTGGCCT 000160
000161 CCAGGTGTGT TGTCTACCCC CCAGGACCTG CCAAGCACGG TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCCGAGG 000240
000241 AGGGAAGATC ACGAGCTCAA GATATCAAGA CCATCCTGGC CAACATGGTG AAACCCTGTC TCTACTAAAA ATACAAAAAT 000320
000321 TAGCTGGGCG TGGTGGTGCA TGCCTGTAGT CCCAGCTACT CGGGAGGCTG AGGCAGCAGA ATCGCTTGAA CCTGGGAGGT 000400
000401 GCAGGTTGCA ACACACTACT AACTCCAGCC TGGGCGACAG AGCAAGACTG TCT
000081 TGCTGGACCT AAAAAAGGTG TTGGCCCACG AGTGCCTCTC TCTCCCTGCC TGAGCTCCCT GACCAGCATG CGTGTGGCCT 000160
000161 CCAGGTGTGT TGTCTACCCC CCAGGACCTG CCAAGCACGG TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCCGAGG 000240
000241 AGGGAAGATC ACGAGCTCAA GATATCAAGA CCATCCTGGC CAACATGGTG AAACCCTGTC TCTACTAAAA ATACAAAAAT 000320
000321 TAGCTGGGCG TGGTGGTGCA TGCCTGTAGT CCCAGCTACT CGGGAGGCTG AGGCAGCAGA ATCGCTTGAA CCTGGGAGGT 000400
000401 GCAGGTTGCA ACACACTACT AACTCCAGCC TGGGCGACAG AGCAAGACTG TCT
Expression
LncRNALUADT1 expression was up-regulated in colorectal cancer, and correlated with tumor size, metastasis, and TNM staging [1]
Function
LUADT1 regulate cell cycle progression by epigenetically inhibiting the expression of p27.[2]
Labs working on this lncRNA
- Department of Coloproctology, The Hangzhou Third Hospital, Hangzhou, China. shenzhong114@sina.com.[1]
- Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing 210009, China.[2]
References
- ↑ 1.0 1.1 Zhang XF, Zhang Y, Shen Z, Yang GG, Wang HD, Li LF, Liu DC, Qiu JM. LncRNALUADT1 is overexpressed in colorectal cancer and its expression level is related to clinicopathology. Eur Rev Med Pharmacol Sci. 2018 Apr;22(8):2282-2286. doi: 10.26355/eurrev_201804_14816. PubMed PMID: 29762830.
- ↑ 2.0 2.1 Qiu M, Xu Y, Wang J, Zhang E, Sun M, Zheng Y, Li M, Xia W, Feng D, Yin R, Xu L. A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27. Cell Death Dis. 2015 Aug 20;6:e1858. doi: 10.1038/cddis.2015.203. PubMed PMID: 26291312; PubMed Central PMCID: PMC4558496.
