EVA1A-AS

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Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor.

Annotated Information

Name

Approved symbol:EVA1A-AS

Approved name:EVA1A antisense RNA

HGNC ID:55283

Alias symbol:EVA1A-AS1

RefSeq ID:NR_110281

Characteristics

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Function

Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor[1].

EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].

Regulation

Depletion of EVA1A-AS suppressed cell proliferation of HepG2 cells by upregulation of EVA1A. Overexpression of EVA1A caused cell death at the G2/M phase via microtubule catastrophe.[2].

Expression

suppressed EVA1A expression levels are negatively correlated with differentiation grade in 365 primary HCCs, while EVA1A-AS expression levels are positively correlated with patient survival.[2].

Diseases

  • Hepatocellular carcinoma.[2].

Labs working on this lncRNA

  • Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany.[2]
  • Klinik für Orthopädie OE8893, Medizinische Hochschule Hannover, Stadtfelddamm 34, D-30625, Hannover, Germany.[2]
  • Zentrale Forschungseinrichtung Genomics OE 9415, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany.[2]
  • Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany. Tran.Doan@MH-Hannover.de.[2]

References

  1. 1.0 1.1 Cite error: Invalid <ref> tag; no text was provided for refs named ref
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Cite error: Invalid <ref> tag; no text was provided for refs named ref1