Lnc-EPCAM-1:2

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Annotated Information

Transcriptomic Nomeclature

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Function

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Regulation

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Expression

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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Basic Information

Transcript ID	lnc-EPCAM-1:2
Source	LNCipedia2.1
Same with	,
Classification	intergenic
Length	200 nt
Genomic location	chr2+:47562453..47562653
Exon number	1
Exons	47562453..47562653
Genome context
Sequence	000001 GGCCGGGCGC GGTGGCTCAC GCCTGTAATC CCAGCTCTCA GGGAGGCTAA GAGGCGGGAG GATAGCTTGA GCCCAGGAGT 000080 000081 TCGAGACCTG CCTGGGCAAT ATAGCGAGAC CCCGTTCTCC AGAAAAAGGA AAAAAAAAAA CAAAAGACAA AAAAAAAATA 000160 000161 AGCGTAACTT CCCTCAAAGC AACAACCCCC CCCCCCCTTT

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Annotation (From lncRNAdb)

[lnc-EPCAM-1:2]

Section	Description
ID	BC200
Characteristics	200 nucleotide ncRNA (Tiedge (1993)) exapted from an Alu element (Watson (1987)). Transcribed by RNA polymerase III (Martignetti (1993)). Three structural domains, 5' that shares homology with Alu elements, a central A rich region and a 3' unique region (Tiedge (1993)).
Expression	Expressed predominantly in different regions of the brain. Also shows low level expression in testis but not in other normal tissues examined (Watson (1987), Tiedge (1993), Kuryshev (2001)). RNA sequencing of 11 human tissues confirmed up-regulation of expression in brain (hypothalamus) and low or no expression elsewhere (Castle (2010)). Disregulated in cancer: expressed in a number of human tumours but not in corresponding normal tissue (Chen (1997)). Link with aging and Alzheimer disease: BC200 expression decreases with aging but is upregulated in Alzheimer's disease (AD). In AD affected brain regions, expression increased with disease severity. RNA localisation showed intense perikaryal staining, showing build up of RNA in cell body (Mus (2007)). Like BC1 ncRNA found in rodents, BC200 also suggested to localise to dendrites (Tiedge (1993)).
Function	Binds several proteins including the signal recognition particle SRP9/14 heterodimer (Kremerskothen (1998)), eukaryotic initiation factor 4A helicase (eIF4A) (Lin (2008)) and Poly(A)-binding protein (PABP), binding to PABP requires the central A rich region (Muddashetty (2002)). Inhibits translation in-vitro and in cultured cells similar to BC1. BC200 binding to eIF4A inhibits it by uncoupling eIF4A ATPase activity from its helicase/ duplex unwinding activity (Lin (2008)). Translational inhibition also involves BC200 binding to to PABP (Kondrashov (2005)).
Conservation	Anthropoid primates (monkeys, apes and humans) (Skryabin (1998)). BC200, BC1 and G22 likely form a family of independently exapted repetitive elements which have evolved to carry out similar functions in different mammalian species (Muddashetty (2002), Khanam (2007)).

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