NONHSAT023851

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Annotated Information

Name

PR antisense transcripts

Characteristics

Found several antisense transcripts which initiate in the progesterone receptor (PR) promoter region. AT1 and AT3 were unspliced. AT2-T47D and AT2-MCF7 were spliced with seven exons and transcribed over a 70kb region. AT2 isoforms initiated between the PR A and B start sites, had different (cell line specific) start sites but were otherwise identical. AT2-T47D ~1.35kb. AT2-MCF7 ~1.5kb.

Expression

Expression identified in human breast cancer cell lines (MCF7 and T47D). AT2 isoforms were the most highly expressed antisense transcripts. AT2 isoforms could be detected in the nucleus.

Function

All function characterisation was on the AT2 isoforms. PR antisense transcripts act as a scaffold for other RNAs and proteins to bind, allowing them to regulate transcription of the progesterone receptor. Different small RNAs targeted at PR antisense transcripts can activate or repress PR transcription. A PR antisense transcript was necessary for activating PR transcription via a small RNA. PR antisense transcripts could associate with small RNAs, Argonaute proteins and hnRNP-k to bring about regulation of the PR protein coding gene.

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT023851
Source	NONCODE4.0
Same with	,
Classification	antisense
Length	1532 nt
Genomic location	chr11+:100999808..101069641
Exon number	7
Exons	100999808..101000619,101001420..101001513,101003742..101003856,101018874..101018963,101029890..101029986,101066216..101066370,101069460..101069641
Genome context
Sequence	000001 TGGACTCCCC TTTTCTCCTC CCCCGTCTCC AGGAGGAGGG AAAAGGGAAG GAGGAGGGGG TTTCGGGAAT ATAGGGGCAG 000080 000081 AGGGAGGAGA AAGTGGGTGT TGAATGTGGC TGGACCGGAG GGATCTCCAC CTCCTGGGTC GGGGGCGGGG GAGGGCGGCG 000160 000161 CTGGTCAGCT CCTGCCCTTG GCCTCCATCC TGTCGTCAGG GGAACTGTGG CTGTCGTTTG TCCCAGCGAG CGGCAAGTGG 000240 000241 GGAGCGCAAG AAAAAGTAGT AATTGTTAGG AGATCTCGTC TCCTAACTCG GGGAGTTCTC CAAGAGAGTT CTCCAACTTC 000320 000321 TGTCCGAGGA CTGGAGACGC AGAGTACTCA CAAGTCCGGC ACTTGAGTGG CTGCGGCTGC GACGGCAATT TAGTGACACG 000400 000401 CGGCTCCTTT ATCTCCCGAC TTTTTCTCTG GCATCAAACT CGTGCATGCT GTGAAGCTCT CAGTCCCTCG CTGAGTTCCA 000480 000481 CTGCCCCCTC ACTAAAACCC TGGGGCTAGT CGGACCTCTC GGTACAGCCC ATTCCCAGGA AGGGTCGGAC TTCTGCTGGC 000560 000561 TCCGTACTGC GGGCGACAGT CATCTCCGAA GATCTCAGAT CCCAGTAGTG CGGGAGCACT AGCCGCCTCG GGTTGTAGAT 000640 000641 TTCACTCAAA TGACAAGTGA AGCTAGTTCT CATTGAGAAT GCCACCCACA CGCACAAATA CAACAAGGCT TACCCCGATT 000720 000721 AGGACAGTGT GGACTCCAGA CAGTTTTAAC AAGCCTCCTC TCTAGGGGCC CGCCCAAAGC CCCTCCCTAC CCCAATTACC 000800 000801 GGACCTCAAG GTCTAGCTGT GCTAATGACT CATAGTTTAT TCACCATGTA TAAAGAATGC AGAAGACTCC AGAAGGTGGG 000880 000881 GGAGCCACTA GAGGATTCCA TCCAGGACAC CACATTTAAT TGTTATGATG TCTTGTGCTC CTCTTGGCTG TGAGAGTTTC 000960 000961 TCAGATTTTC CTTGTATTTG ATGACCTTGA CAGTCCTTAG GAGTACTGAG ATGGGGGTTT CACGATATTG CCCAGGCTGG 001040 001041 TCCCAAACTC CTGGCCTCAA GCTATCCTCC TGCCTTGACG TTCGAAAGCA CTAGATTTTC CTTCTGTCCT GCCGCCATGT 001120 001121 GAAGAAAATG TGTTTGCTTC CCCTTCCCCG TGATTGTATT TTCCTGCAGC CTCCCCAGCC AAGCTGAACT GCAATGAGGA 001200 001201 AGCAATAAAG GACTTGAGCA AGAGAACGAT GTATATAGGC CATTGTTTTG GAAGATTCAT CCAAATTCAT GTGCAAGTAG 001280 001281 ATTGGAGGAA GGAAGTATCA ACAAAAAAAG GCCAATTATG AGACCATTGC AATACTATAT GATGAGAGCA TCAGAGCAAT 001360 001361 AACCAAGGTT TATAGATACC AAGTGAGGAA TCTGGGATTA AAGTCAGTTA TTTCATTGGA AAGGCTGTTT TCAGTTTTTT 001440 001441 CACTGGAAAA GTTGTCATCC TGTGTCTTTT TATAGTACAT ATATTCAGTA ATAAAACTTT ATTTTCCTTT TCAAAAAAAA 001520 001521 AAAAAAAAAA AA

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