NONHSAT074775

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Annotated Information

Name

Zeb2NAT: Zeb2 natural antisense transcript

Characteristics

>1.2 kb; antisense to Zeb2 (a transcriptional repressor of E-cadherin) (Nelles (2003)).

Function

Controls translation and therefore function of the Zeb2 protein coding gene through regulation of Zeb2 mRNA splicing (Beltran (2008)). Zeb2 translation requires retention of an intron, Zeb2NAT overlaps the 5' splicing site of this intron and when expressed inhibits splicing allowing translation of Zeb2 (Beltran (2008)). Snail1 acts to stimulate Zeb2 synthesis via post-transcriptional regulation which appears to be mediated by Zeb2NAT (Beltran (2008)).

Expression

Expression is upregulated by Snail1 (Beltran (2008)).

Conservation

Good conservation between human and mouse (Nelles (2003)).

Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT074775
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	1187 nt
Genomic location	chr2+:145275982..145278683
Exon number	4
Exons	145275982..145276142,145277526..145277677,145277782..145277984,145278013..145278683
Genome context
Sequence	000001 GCTGTGCCTC GAGGATTAGT TTAAACAGGG GGCTATAAAA GATGTAACAG ATGCAAACTG TAACACAAGG GCCATTAACC 000080 000081 CTTTCTCTGC CGGGCACACT CAGTCCCCAC GCCCCACACC TATTGTCTCC TGTGCTAGAA GCTTTGCAGA AAACCTGGAA 000160 000161 ATTTTGGCCA GAAATGGTGA GAAGAAAAAG CATGAAGAAG CCGCGAAGTG TGGGGGAGAA AAAGGTGGAA GCGAAGAAAC 000240 000241 AGCTCCCGGA GCAAACTGTA CAAAAACCTC GCCAAGAGTG TCGGGAGGCA GGACCGTTAT TCCTGCAGAG CAGGAGAGAG 000320 000321 ACGAGAGACC CTGAAACACG CGCCACCTAT CTTTGTGGGG AGGGATAATT GAAGCGCCCT GAGCGTGAGC ATCATGTGAA 000400 000401 AACGTGATCG CCAAGTTTCT CTCTGGGAAA GGATCTGGGA TAGATTATAC CTTGAAGTCT CCGCAAACGC TTTAGTGGAA 000480 000481 GAAATGAAAT TCCACCTCCC TCCCTTCCTC CTCTCCCTCC CTCCCTTCTC CCCCCCTCCA CCCCCCCCTC CCCGCCCGTC 000560 000561 AAGCCTTTGG CATCATTATC CTCATCACTA AATCCTACAG AGTACAGGGC GGAAAACGGT GCACACCATT CACAGAACTG 000640 000641 GAGAACTCCA AGGGGCGAAA GTTAAAGGGA AAGATCCCGG GTCCTCAATC CAGATAGTCT CTTCTTATAC AGATATCTCT 000720 000721 AATGACCAGA TTTGAGATGC ACATCAAATT GTGTAGGTAT CTCAGTACAG CTTCTGGAAC AAAGTTCTCT GCCCTTTCTC 000800 000801 TTATTGTTAT TTTTTTCTTT TTAGGTACCA GAGCCAGAAA AAAAAATGCT GCATGGGAGC TGCATCTTAG GGCATGTGTA 000880 000881 TTAGGGTGTG TGCATGATGA ATTTCTGGAC TGGATCCCAA TATTAAAAAG TAGTTTGGCA TTTTAATAAA GGGTCTCTAA 000960 000961 GTAAATTAAA ATAGAACACT CGGTTGGCCG ATCTCTGAAT CTCTCTACAC CTCGGGGAGA CCTCACTACA AAGTAAGGGA 001040 001041 GAGTGTGTAG GGAGGCAGGA GGAGAAACGA GAAAGGCCAT AGAGAAACTT AGCAGGGAAG GGAGAGCATG ATATTAAACG 001120 001121 GCATGGGGTC TAAGTTTTGG AGTATATATT TTTTGATATT ACAATTAAAG TAAGATTAAA AAGAAAA

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