NONHSAT035954
AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4gene cluster in cis and trans.
Contents
Annotated Information
Transcriptomic Nomenclature
DHRS4-AS1:DHRS4 antisense RNA 1 (HGNC nomenclature)
Function
AS1DHRS4 Regulates DHRS4 Gene Cluster Transcription.[1]
AS1DHRS4 Interacts with H3K9 and H3K27 Methyltransferases to Maintain Epigenetic Silencing of the DHRS4L2 and DHRS4L1 Genes.[1]
AS1DHRS4 has both specific cis and trans activity on inducing different repressive enzyme complexes in the individual promoters within the DHRS4 gene cluster locus.[1]
Regulation
Please input regulation information here.
Expression
Knockdown of AS1DHRS4 had no effect on DHRS2gene expression at the transcriptional level Knockdown of AS1DHRS4 increased both mature mRNAs and pre-mRNAs of the DHRS4 gene cluster[1]
| siRNA Name | Sequences |
|---|---|
| siASDhrs4-1 | sense:AACUCAUUUGGUAAAAUGGTT[1] |
| antisense:CCAUUUUACCAAAUGAGUUTT[1] | |
| siASDhrs4-2 | sense:UGUUUCUGGAUGAAGACUCTTT[1] |
| antisense:GAGUCUUCAUCCAGAAACATT[1] |
Labs working on this lncRNA
Department of Cell Biology, Shantou University Medical College, Shantou 515041, China
References
[1](1) </references>
Basic Information
| Transcript ID |
NONHSAT035954 |
| Source |
NONCODE4.0 |
| Same with |
DHRS4-AS1,C14orf167, "chromosome 14 open reading frame 167", "DHRS4 antisense RNA 1 (non-protein coding)" |
| Classification |
antisense |
| Length |
3038 nt |
| Genomic location |
chr14-:24407940..24423392 |
| Exon number |
2 |
| Exons |
24407940..24410367,24422783..24423392 |
| Genome context |
|
| Sequence |
000001 AGAACACTGG GGAGACTAGA TCGATAGGGC TGCACAGAGG TGGCACAGTT GTGCCAGAGG TAGCAGGGAC AGGAGGGCTG 000080
000081 GCAAGGGAGG GTCCAGGGCT AGGGGATTCG GAGTGGCTTC AGGCGGACCA CGTGGCTACC TTTTTTCCAG GGCCAGACTT 000160 000161 TGGCAGCGTG TAAGGTCTGA GGACAGGGGC ACCGGAGGCC GAGGATGAGA GGCCAGTGCC TGTTTCCAGG CAGCCAGGGC 000240 000241 CTCAGAAACT CCGGCCGGAG CACTCACCCG TCGGTGGAGG CCGTTACCAG GGCCACCTTA TTTGCGAGCG GGTCCCGGCG 000320 000321 GGTCATCCCG GAGCTGGCCA TCCGCACCGA ATTCCAAGCC CGGGCACAGA GGCCTAGCAG CCCCGCCTTG TGCATGGATC 000400 000401 AGACCAGCAA GTATGGGTTC CACTCTTCCC AGGGGCGGTG ACAGAGTAGG GCGAGGGGCA GGACGAAGGG CGGGCCGATT 000480 000481 CCCTGCCCGC CCTGCTCCCC GCCCCGGTAC CGCTGTGAGC GGTCTGTGGC CCTGGGCACC TCCATCCGCC GCGGCGCCCC 000560 000561 TCCACCATCT ACCTTCCGCC TGACTGGGGC TTGCCTTTCC GGGCTGGCGG GTGCCACTTC GGATAAACCC TTTGGACTCC 000640 000641 TAACTCCAAT CAGGTGTCTG CTTTGTTGAG GACTCACAGA CACAGTCTCC TTTCTTCAAG ATCTTTACAA TGCAAGACCT 000720 000721 CACTAACACA CAGGGATGGT CTCCCAGAGG GTCTGTGCTG TTCCTTCACT CAGAACATCA AGATGCACTG AAGTAAGGAT 000800 000801 CCTCTATTCT ACAGTTCCTG CTAGCTGAGC TATTCCATGG GGGCTTCAGC AGGAAATTCC AAGGTTGGCT TTGACAAGCT 000880 000881 AAGGCCGGCT GGTGGAGCAC ATCGAGTTCT GGAGGTTCAT GTGTGTTTTC ATGAAGATCT GTCTGCCCGT AGCAGATAAA 000960 000961 GAGTTGTTGC CCCACTCCTC CTGGGGTCTT CTATTTTCCT GGGAGGAATT TCTGGATTAA CTGAACACAC ACACACACAC 001040 001041 ACACACCCTT TTGAAGCATC AACAGTAATT CTGAGTTCTT AGGGACAATG CAGATTAAAT CCACAATAAG AAAGACAACT 001120 001121 ATGGCCAGGT GTGGTGGCTC ACGCCTGTAA TCCCAGAACT TTGGGAGGCT GAGGCGGATG GATCACCTGA GGTCAGGAGT 001200 001201 TAGAGACCAA CCTGACCAAC ATGGAGAAAC CCCGTTTCTA CTAAAAATGC AAAATTAGCC GGGCATGGTG GCAGGCGCCT 001280 001281 GTAATCCCAA ATACTCGGGA GGCTGAGGCA GGAGAATCAC TTAAACCCGG GAGGCAGAGG TTGCAGTGAG CCAAGATCGC 001360 001361 GCCATTGCAC TCCAGCCTGG GCAAGAAGAG CAAAACTCCA TCTCAAAAAA AAAAAAAGAG TACTATTGAT CCAGAGGTGA 001440 001441 CCAGACTAGC CTCACTGGAG ATAATAGGTG ACATTATTAT GCAAAGTGGT TTCAGTTCCC TTGTCTTGTT TTTGGAATAG 001520 001521 TATAAGAGGC CTACAATACG AATAAATAAG GCCCATCACA AGCCTCACCA AAGGACAAAA CTAATCCACT TCTGAAGAAG 001600 001601 GCTCTTTGTT GGGCCAGATC AAATCCTTGG ACAGAACTGT ACTCTTAATC TCTGTAGTGA AAGTGGGGGG TAGTTTAAGA 001680 001681 ATTTATTAAC CTTCTACCTT GAGCAATCCC TCAGAAGTAA GAGGTGTCAG GCCTCTGAGC CGAAGCTCAG CCATTGTAAC 001760 001761 CCCTGTGACC TGCACATATA TGTCCAGATG GCCTGCAGGA GCCAAGAAGT CTGGGGCAGC TGAAAAACCA CACAAGAAGT 001840 001841 AAAACAGCCA GTTCCTGCCT TAACTGATTA ACCAACATTA CAACATTCCA CCATTGTGAC CTGTCCCTGT CCTACCTTAA 001920 001921 CTGATCAATC GACCTTGTGA CAGTCTTCTT CTGGACAATG GGTCTTATCA TCTCCCCACC ATGTACCTTG TGACCCCCTC 002000 002001 CTCTGCTAAC AATAGATAAC CACTTTTTAC TGTAATTTTC CATTACCTAC CCAACTCCTA TAAAGCAACC CCTTCCCCAT 002080 002081 CTCCCTTCAC TGACTCTGTT TTCAGACTCA GCCCACTTGC ACTCAAGTGA ATAAACAGCC TTGTTGCTCA CACAAAGCCT 002160 002161 GTTGGTGGTC TCTTCACACA GATGTGCTTG ACAAAAGGGA AGGGTGGATT TGTCCTTCTG GTTACATATG TTCTGCTCAC 002240 002241 TCATTTTGAA TTTAATTAAA CAAGGATTGC CCTTACCTTT TCATACTTTG TAAGAAACCA TAAATACTTA TGCACCATGA 002320 002321 TTTTTTTAAA GAAACACTTT TTATTTTGAA GTAATTATAG TCTCATAGGA AGTTGCAAAA GTAGTACATA GAGTCCCTGA 002400 002401 GTACTCTTCC CCCAGTGGTG ACAACTGTAG TATAATATCA ATTCTGGGAA ATTGACATTG GTACAATACC AAATATACTA 002480 002481 TGCCTTTTTC TCTAAGGCAT GATGTTGCAG TAGCATCCTT GTACATGTAG CTAGGAGAAC TTGTACTAAG CCCAGATAAA 002560 002561 TAGTTGAAGT ACAAGGGCAA GGAGTGTGTC TTTGATATTT TAATAGAAAT CACCTATTGC CCTCTAGAAA AGCTGTACCC 002640 002641 TTTTCCAGTG GCAGAGAACC TTCCTGAAAG GCAGTCCTGT GTAATGGTGT CCATTTCATC ACACCCTTAA AACACTCAGC 002720 002721 TTTAACAAAC ATGCAGATTT TTGCTGATGT GGGAGAAAAT ATTAATTATT AATGATATTA AGGTGATTAT CTTTTCGTAT 002800 002801 GTTTATAGAT ATTTGTATTT CTTTTTAAAT GAACTGCTCA TGACCTTTGT CTACTTTTAT TTGGGTTTAC TTCTTTCTCA 002880 002881 TTTATTCCTA TAAACTCTTT ATAAAAGGAA ATTAACCATT TGATTGTCAT ATGTTGTGAA TATTTTTACC ATTTTGACTT 002960 002961 TTGAATTTAT GTCTTTTTAA TGAATTGTAG AAGTTTAAAA TCTTTATGGA ATAAATTTAT TTAGTTTTTT GTTTATGG |
- ↑ Li Q, Su Z, Xu X, Liu G, Song X, Wang R, et al. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans[J]. Proceedings of the National Academy of Sciences of the United States of America. 2012,109(35):14110-5
