Lnc-CDKN1A-1:1

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Annotated Information

Name

PANDA

Characteristics

Bidirectional transcript from the CDKN1A promoter.

1.5kb single exon.

Sequence runs antisense through a processed LAP3 pseudogene and contains a SINE.

Function

P53 effector gene, acts in response to DNA damage to limit apoptosis while CDKN1A induces cell cycle arrest.

Loss of PANDA leads to the apoptosis of doxorubicin treated cells.

Loss of PANDA affected the expression of many genes during the DNA damage response. Upregulated genes were enriched for those involved in apoptosis, including the apoptotic activators APAF1, BIK, FAS and LRDD. Leading to apoptosis of doxorubicin treated cells.

Cell death genes downstream of p53 are known to have NF-YA binding sites. PANDA RNA interacts with the transcription factor NF-YA and attenuates its occupany of target gene promoters.

Expression

One of five lncRNAs surrounding the transcription start site of the cell cycle gene CDKN1A that, along with the CDKN1A protein coding gene, were induced in human fetal lung fibroblasts upon DNA damage by doxorubicin.

Induced up to 40 fold upon DNA damage peaking 16 h after doxorubicin treatment, a much greater response than shown by CDKN1A.

Expression of PANDA and CDKN1A were positively regulated by p53. CDKN1A did not induce PANDA.

Conservation

Syntenic sequence appear to be present in apes and old world monkeys (the Catarrhini).

Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	lnc-CDKN1A-1:1
Source	LNCipedia2.1
Same with	,
Classification	intergenic
Length	1506 nt
Genomic location	chr6+:36641397..36642903
Exon number	,
Exons	,
Genome context
Sequence	000001 ACGAATTCTT TCAGGAATGC CGCAGATGTA CATGCTCCCG CAGATCTATA TTTTCCAATG TTGTTAACAT CAGCCAGCTG 000080 000081 GCAATCTACA ACCTGTCTTG TACAATGTTT GAAGAGAGGC ATCCTCCAGA CACGGTCCCC TGTTTCAATG CTGGCCTCGA 000160 000161 AGAGCTTGTT CCAGAGCCAG GATGAATTGG TAAAGACCCC AGTGGCACCT GACCCCAAAG CTACATCTAT GACACCTGTT 000240 000241 AAGGTGGTGG CATTGAGGAT GACCTTCGGG TTAAATGTGT GCACGTAACA GAGCGCATCA GCCAGTATGA GCCTCCCCTC 000320 000321 AGCATCAGTG TTACCAACCT GGATGGTCTT CCTGTTCCTG GCTCTAACAA CATCCCCCAG CTTGTTGGCC TTGCCGCTGG 000400 000401 GCATGTTTTC ACAGAGGGGC CAGACCTATA ATATTAATGG GCAAACTGAG ATTTGCAGCA GACACAATGG CTGAGCATAT 000480 000481 AGTTGTAGCT CCTCCCATGT CGGCCCTCAT GAGGTCCATA TTTGCAGAAG CCTTGATGGA GATACCACCA CTGTCAAAGG 000560 000561 TAATTCCTTT CCCAACAAAC AAGGGGTGGT TTGTCTGCAT TGGGGCTGCC TATGTAGTGA ATTTCCAAGA AGACTGAGGG 000640 000641 CTCGTCAGAT CCTTTGGCCA CACTGAGGAA TGATCCCATT GCCTGTTCCT CAATCCAAGA CCTGGGTCTG ATATGAAACT 000720 000721 CGGTTTACTA CTAGCGCTTT TGAGATTCTT CTCAATAATT TCGGCAAATC TGGTTGGCAT CATCTCGCTG GCTGGCGTCT 000800 000801 CCATCATGCC AAGTTCTGCC CAGAAGCAAA CAGGACTCCT TTCTGCCAGG CCTCCTGATC CCCAGTTCCA TAGAGCTTCA 000880 000881 CCGACATAGC CATCTTCTTT TTTTGCTTTA GGTCATCGTA TTCATAGAGA CCAAGCACCG CGCCCTCCTC AGCAGCCTGA 000960 000961 GCATCTCTAC AGGGATCCAC CTCCACGGAA GAGAGCTCCA GGTCTTGAAT CTGCCTGCAT CCTGCTGCAA CAGCAGCTCT 001040 001041 GATGTTTTCT TTGCCTTCCT GCCAGTTTTC CTGTTCGTCG ATTCTGGCTG CCTTTTTGCC GAGGCCAACT AGCACCACGC 001120 001121 TGGGGAAGTC CTGATGCAGA CCATAAAAGT TTCGAGTCTT GCCTGCCTTC AGAGGTGGTC CAGATATGTT CAAAGTCTCT 001200 001201 CTCAGCTTTC CAGCTATCAA TTTATCAAGA TTCTCTCCTG CACTTGTGAA CTGTGGCACA TCATCTTCTT TTTCTTTGGA 001280 001281 ATAGATTCCT AAAACAAGGC CCTTCGTCAT GTCTGCAGCG GAGAGACCCC GGCTCCCGAA ACATCTCACG GCCAGACGTC 001360 001361 AGACGATGAC TCGCCCCACC CAATGTTTGT ATTTTAGTAG AGAGAGGGTT TCTCTATGTT GGTCAGGCTG GTCTCAAACC 001440 001441 TCGACCTCAG TTGATCTGTC TGCCTCGGTC TCCCAAAGTG CTGAGATTAC AGGCGTGAGC CACTGC

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