BANCR
BANCR, BRAF activated non-coding RNA,a 693-bp transcript on chromosome 9, actively functions as a regulator of EMT during non-small cell lung cancer(NSCLC) metastasis.
Contents
Annotated Information
Name
BANCR: BRAF-activated non-protein coding RNA (HGNC nomenclature) LINC00586[1]
Function
BANCR inhibits migration and invasion of NSCLC cells and induces apoptosis, which possibly also affected EMT[1].
Downregulation of BANCR may be a negative prognostic factor for NSCLC patients, and indicative of poor survival rates and a higher risk for cancer metastasis[1].
Regulation
Histone acetylation is a key factor in controlling lncRNA BANCR expression[1].
Expression
BANCR is overexpressed in melanoma cells and crucial for melanoma cell migration. Specifically, BANCR expression was significantly lower at the later stages of tumor development, and in tumors that had undergone extensive metastasis[1].
| Primer | Sequence(5'-3') |
|---|---|
| BANCR F | ACAGGACTCCATGGCAAACG[1] |
| BANCR R | ATGAAGAAAGCCTGGTGCAGT[1] |
| si-BANCR | GGAAAUAGACUGCAGCACCAATT[1] |
Diseases
Sequence
>gi|392973718|ref|NR_047671.2| Homo sapiens BRAF-activated non-protein coding RNA (BANCR), long non-coding RNA
000081 TCTTGTAGGG TCTGGATTGG GACCCTTTTC TGGTAACATC TTCCTGGTGA CCATGAAGGG ACAATACTGA AGAGACCCCT 000160
000161 GACCCTAAGG AAATAGACTG CAGCACCAAT GGGCCAACTT TGGGGCGATC ATCTTGCCCA GAAACATCAT GTTGAAACTC 000240
000241 TTGGTCAGAG GTTGGATGAA AGCTGACAGG GTCCATCCAG GAGCAAGTTT GAGCCTTGCC AGTTCCATTT TGGGTGCTGA 000320
000321 GTGGAGTGGC GACTATAGCA AACCTGTGAT CTCTGGCTGC TGCTCAGAAG AAACAAGAGG GAGGGATGAA TAATGTAAAA 000400
000401 CTCTGGATCA ATATTCTAAT TCTGAGCCTC TATTGGAATC AGCTAGCAAC CACATATCAG CTTGGTTTCA ACAGTTTCCC 000480
000481 AGTTCATGCT GCTGAGAAGT TCAGAGTCAA ACCTGAATCT CACCTCTGCA AAGAGCACAG GACTCCATGG CAAACGTTGT 000560
000561 ATATACGCAA GTCATCCCTG GCACCACATT GATTTACTGC ACCAGGCTTT CTTCATTGTG ATGATGTTCT CTCTCTTTTC 000640
000641 TAAAAAAAAA ATAAAAATAA AATTTAAAAA ATCCTAAAAA AAAAAAAA
Labs working on this lncRNA
- Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, People's Republic of China. [1].
- Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.[2].
- Department of Gastroenterology, Qi-Lu Hospital, Shandong University, Jinan, 250012, Shan Dong Province, People's Republic of China.[3].
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Sun M, Liu XH, Wang KM, Nie FQ, Kong R, Yang JS, et al. Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition[J]. Molecular cancer. 2014,13:68.
- ↑ 2.0 2.1 Peng ZQ, Lu RB, Xiao DM, Xiao ZM. Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma[J]. Genetics and molecular research : GMR. 2016,15(1).
- ↑ 3.0 3.1 Zhou T, Gao Y. Increased expression of LncRNA BANCR and its prognostic significance in human hepatocellular carcinoma[J]. World journal of surgical oncology. 2016,14(1):8.
