HNF1A-AS1

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Annotated Information

Approved Symbol

HNF1A-AS1

Approved Name

HNF1A antisense RNA 1

HNF1A-AS1 is highly expressed in human gastrointestinal track and is upregulated in human oesophageal adenocarcinoma (EAC). [1].

Previous Symbols

C12orf27, NCRNA00262

Synonyms

FLJ38690

Chromosome

12q24.31

RefSeq ID

NR_024345

Ensembl ID

ENSG00000241388

pubmed IDs

24000294, 25863539

Disease

  • oesophageal adenocarcinoma
  • lung adenocarcinoma

Characteristics

HNF1A-AS1 is a 2455-nucleotide single-exon gene located at chromosomal band 12q24.31 and it is also a bidirectional IncRNA corresponding to the hepatic nuclear factor 1 alpha gene (HNF1A, also known as transcription factor 1 or TCF1), whose transcriptional start site occurs approximately 5 kb 5′ to that of HNF1A-AS1 [1].

Function

HNF1A-AS1 is involved in the promotion of EAC cell proliferation and anchorage-independent growth, two cancerous processes in epithelial cells[1]. HNF1A-AS1 involves mechanisms relevant to the promotion of EAC cell migration and/or invasion [1]. At least one HNF1A-AS1-responsive pathway likely involves chromatin/nucleosome assembly during the G1/S transition [1]. HNF1A-AS1-mediated promotion of EAC cell proliferation and survival appears to be mediated by modulation of the G1-S checkpoint, rather than by apoptosis [1].

Regulation

H19 may represent an important downstream effector of HNF1A-AS1, potentially mediating this IncRNA’s effects on tumour growth [1].

Evolution

HNF1A-AS1 is evolutionally poorly conserved , yet widely expressed in the aerodigestive tract [1].

Expression

There is a significant positive correlation between HNF1A-AS1 and H19 expression in primary EACs [1].

HNF1A-AS1 is significantly up-regulated in lung adenocarcinoma tissues compared with corresponding non-tumor tissues, and its expression level is significantly correlated with TNM stage, tumor size, and lymph node metastasis [2].

Labs working on this lncRNA

  • Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [1].
  • Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China [2].

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Yang, X., J. H. Song, Y. Cheng, W. Wu, T. Bhagat, Y. Yu, J. M. Abraham, S. Ibrahim, W. Ravich, B. C. Roland, M. Khashab, V. K. Singh, E. J. Shin, A. K. Verma, S. J. Meltzer, and Y. Mori. "Long Non-Coding Rna Hnf1a-As1 Regulates Proliferation and Migration in Oesophageal Adenocarcinoma Cells." Gut 63, no. 6 (2014): 881-90.
  2. ↑ 2.0 2.1 Wu, Y., H. Liu, X. Shi, Y. Yao, W. Yang, and Y. Song. "The Long Non-Coding Rna Hnf1a-As1 Regulates Proliferation and Metastasis in Lung Adenocarcinoma." Oncotarget 6, no. 11 (2015): 9160-72.

Sequence

>gi|211064492|ref|NR_024345.1| Homo sapiens HNF1A antisense RNA 1 (HNF1A-AS1), long non-coding RNA

000001 AGTAAGTGCA GTAGGTAGGC CAAGATAACT ATTAAGTATG TCCTAACAAG GTAGCTGCTT GAAAAAAATA ATGCACATAA 000080
000081 ATTAAAAAAA AAAAAACTAT TTTCACTCAT TCTTAACTTC TCGTATGGAT GTACTAACGG GAGGCCTGTG CCTGTTGGGC 000160
000161 TGTCCACAGC TACTCAAACC TTGAGATTAG ATTGGACGCT ATCTAATCTC ATTTCCTGTT ACACAATAAC TTCTGCATGG 000240
000241 CACTTGCTTT TAATCATGAC AACTGCCATA CACTCAGCTT TACAAAATCA TGTCATTGTG GAAAGGAAGT TCCCTCCATC 000320
000321 TAACATTCAA ATTTAACTAT CCTGAGCTGG TAGTTTGCAA GGTGTCCAAC AGATGTCACT GTGTTTCCTT CGCAAATTCT 000400
000401 CTAAAATAGT CTGCTGTGTC CCGGGGCATA GTAGATATTC AAGAAATGGT GGCTATGAGT TTTATCACAA TTCTCTCCTA 000480
000481 CTGGGTGAGC AGCTGTTTGC AAGACTAAAA TTCGGGCGAG GCACAGGCTT CCCCTTGGTC TTAGCAGCTA GCACAAGACG 000560
000561 AGTGTCCCTT CAGCCAGTCT CAGAGCTCTT TGGCAATTCA ACTGACCCTT GTCCTTCAGT CCAGACAATG CCCCAGGGCC 000640
000641 CACCTGCATT CAAACTCGGA CTGTTCTCCT TCCCACCCCT ATTATCTTTT CAACTTTATG GACAGTACAT GCAATTTTCT 000720
000721 CATTCATTTT CTCATTTAAC ATCTAACAGC TTCATGATAT CCCCATTTTA CAGATAAGGA AACCAAGGCT TTAAGAGGAT 000800
000801 AGGGACCCTA ATCGGCTAAG GCAGAATTAG GATTTGAACC CAGATCCCCA TGACGCCAGA ATCTAAGCCT TGACCAAATA 000880
000881 TGTGTTACTA TTACTTTTGT TGTTGTTGTT GTTCTGGGTA ACTCCAACCC TCTGCTCGTT GGCCTTGTCA CCTCAGTGCT 000960
000961 GATTTTGCAG ATGAAGAGAC TAAGGTTCCG AGGTGCTAGA GCACAGTGGT TAGGAACACA CACTCTAGAG CCAGAGTGCC 001040
001041 TGGGTTTGAG CCTCGTTCTG CCGTTTACTA GCCGTATGGC CTTGGGCAAC TTGCTTAACT TCTCTTTGCC TCAGTTCCTC 001120
001121 TTCTCTTGGG TTGTTAGGAG AATGAATGAG GTGATATCCA CAGTGTCCAA CACCCTGCAA GCGGCCAGGT GTGGTGGATC 001200
001201 ACACCTGCAA TCCCAGCACT TTGGGAGGCC GAGGCAGGTG GATCATTTGA GGTCAGGAGT TCGAGACCAG TCTGGCCAAC 001280
001281 ATGGCGAAAC CTCATTTCTA CTAAAAATAC AAAAATTAGC CGGGCGTGGT GGCAAACAAC TGTAATCCGA GCTACTAGGG 001360
001361 AGGCTGAGGC AGAAGAATCG CTTGAACCCA GGAGACAGAG GTTGCAGTGA GCCAAGATTG CACCACTGCA CTCCAGCCTG 001440
001441 GGCGACAGAG TGAGACCCTG CCTCAAAAAC TAAAAATAAA AAATGAACAG TGTCCAACAC CTTGAAAGCA TTCCGCATGA 001520
001521 CTGAACGATC ACTGTTACGT GATTACCAAC ATGACGACCC CACTTCTCTT GGCCAAACTG AGTTCTCTTC TCTTGTAAAA 001600
001601 ACTTCTGCAT ATGAAGTCAC CCATTCCATT TGACTCTTTA GCCCTCATCC TGGCATTCAA GGGCATGGAC GACTCAACCC 001680
001681 CACTCTCTAG CCAGCCTGAC CTCTCCATTC CCTTCTCTGG CGTAGAGGCC ACTCCCACCA CCTGCCCTTA CCCCCTGCCC 001760
001761 ACTTTTGTCA GCCTGTACTG TGTTGAAGCT CCCAGGAGAG ACAACTGCAG TCATCACTTT CCACTGTGTT CAGTGATGTC 001840
001841 AGTTCGGCCC AGCTGGAGGT ACTCACATCA TGGAAACAGA CCATCAGATT TGGTGTGTGT GTGTTTTATT TTGCTTTTTC 001920
001921 AGAGAGCCAG CTGTTAAACA CTAGCCAACA CCCCATTGAT GCTGTTCCTT CTACCTGAAA CACCTCGCAT TGCCGGTGAG 002000
002001 CTCTAAAGAC AAAAGGACCT GGGTCTGCAT TTCCCAAAGG CAAGACTCTG GTATCACCTG CATA<