KCNQ1DN
Contents
Annotated Information
Approved Symbol
KCNQ1DN
Approved Name
KCNQ1 downstream neighbor (non-protein coding)
Synonyms
BWRT, HSA404617
Chromosome
11p15.5
RefSeq ID
NR_024627
Age‐associated hypermethylation and hypomethylation within KCNQ1DN. [1].
OMIM ID
610980
Ensembl ID
ENSG00000237941
pubmed IDs
11056398, 11063728, 22067257
Tissue-specific expression of KCNQ1DN.RT-PCR analysis demonstrates KCNQ1DN expression in different human adult tissues. [2].
Disease
Wilms' tumor
Expression
KCNQ1DN,is expressed from maternal allele and shows reduced expression in Wilms' tumors [2].
Characteristic
KCNQ1DN is located between p57K1P2 and KvLQT1 (KCNQ1) of 11p15.5 within the WT2 critical region [2].
Conservation
The most remarkable sequence conservation is observed in the 3' regions of the KCNQ1DN gene[3].
Sequence
>gi|219277666|ref|NR_024627.1| Homo sapiens KCNQ1 downstream neighbor (non-protein coding) (KCNQ1DN), long non-coding RNA
000001 GCTGCCCGCA CGCCCCGACG GGAGCTGCGC CCAGCCTCCC CTCTGGAGTC GGCGCTCCAG GCTGCTGCCC GGCCGGTGGC 000080
000081 CAAGGCCCCA GCACCACCGT CCCTCCTGCA GGGCATCCAG CACCTACCCT TCCACTGGGC GGCTCCTGGT TCTGGTCCCG 000160
000161 GCTGGCTCAC TCAGGCTGCC TTTGGACCAG ATTCTTGAAC TTTTCCACCA AGGATGTTGC TGCTGTTTGT AGCGTCGGAT 000240
000241 CCTGGAAAAT CGCTGTGTTG GGGAGCAGCA GGCTCTCCCT TGCTCCCCCA GGGCCTGGGA AAATCAACCC ACCTCTGCCC 000320
000321 CCCGACCCCA GGGCTGTAAC CTGGTGTCTG GTAGCCCCAC TGTGATAAAC CGAAGCCCAG CACAGTTTGG GACTCGCCCC 000400
000401 GAGTTGACTT ATGCAGCCCC CAGAACAGAG GCTGAAACCC GGCGCATCCT GGTGAAGCCA CACCCAGCCG GCCTGGTCCC 000480
000481 AGGCCCCGGG CACGGGGTCC CCTCCACTCC CATCTGCTTC CCTTTCAGAG CCGGGGCTGA GTCGGCAGGG ACGCAGGCTC 000560
000561 AGGGCCCTGG ATTCCCGCTT TCTGGACACT TGCGTGCATG CCCAGCACCA GCTCGCCCTT CTGAGAAAGC AATCCCTCCT 000640
000641 CAGAGGGGAG AAGCCGTGGC TGTGATGGGC AGGAAGTGGT CAGGACCCAC TGCCGAGCAC CAACTCCCCA TGCCACCACC 000720
000721 AGGGGTGCGC CTGGACTCCT GGAAAGGGGT CGCGTCAGGG TGCAGCCCAT CAAAGGCTTC CCAAGAGGCA AGAGGCAAGG 000800
000801 AGAAGTGTCC TACTTTAAAC GGCCAGCCTC AGTGGTCGGC CCTGTTCACT CTGCCACCTC AGAGAGAGTG AACCCAGCAG 000880
000881 AGGTGTGACG GGAGGCTGGG GAGAGACCCC AGCACCTTGA GCACACAGGA GCCAGGAGGA GCCCAACAGA GCAGCAGGGG 000960
000961 CTGGGGTCTT CTCCTGAAGC CTGACTCCAT GGGACCCCAA AGAAGCAGAT GGAAAACTGA AAAAGAAAAC CCCTCAAGTG 001040
001041 AGCCACTGGA AAGAAAGCAA AACAAGAGAA AATAAATGAG TTGTTTGACA TAAAAAAAAA AAAAAAAAA
000081 CAAGGCCCCA GCACCACCGT CCCTCCTGCA GGGCATCCAG CACCTACCCT TCCACTGGGC GGCTCCTGGT TCTGGTCCCG 000160
000161 GCTGGCTCAC TCAGGCTGCC TTTGGACCAG ATTCTTGAAC TTTTCCACCA AGGATGTTGC TGCTGTTTGT AGCGTCGGAT 000240
000241 CCTGGAAAAT CGCTGTGTTG GGGAGCAGCA GGCTCTCCCT TGCTCCCCCA GGGCCTGGGA AAATCAACCC ACCTCTGCCC 000320
000321 CCCGACCCCA GGGCTGTAAC CTGGTGTCTG GTAGCCCCAC TGTGATAAAC CGAAGCCCAG CACAGTTTGG GACTCGCCCC 000400
000401 GAGTTGACTT ATGCAGCCCC CAGAACAGAG GCTGAAACCC GGCGCATCCT GGTGAAGCCA CACCCAGCCG GCCTGGTCCC 000480
000481 AGGCCCCGGG CACGGGGTCC CCTCCACTCC CATCTGCTTC CCTTTCAGAG CCGGGGCTGA GTCGGCAGGG ACGCAGGCTC 000560
000561 AGGGCCCTGG ATTCCCGCTT TCTGGACACT TGCGTGCATG CCCAGCACCA GCTCGCCCTT CTGAGAAAGC AATCCCTCCT 000640
000641 CAGAGGGGAG AAGCCGTGGC TGTGATGGGC AGGAAGTGGT CAGGACCCAC TGCCGAGCAC CAACTCCCCA TGCCACCACC 000720
000721 AGGGGTGCGC CTGGACTCCT GGAAAGGGGT CGCGTCAGGG TGCAGCCCAT CAAAGGCTTC CCAAGAGGCA AGAGGCAAGG 000800
000801 AGAAGTGTCC TACTTTAAAC GGCCAGCCTC AGTGGTCGGC CCTGTTCACT CTGCCACCTC AGAGAGAGTG AACCCAGCAG 000880
000881 AGGTGTGACG GGAGGCTGGG GAGAGACCCC AGCACCTTGA GCACACAGGA GCCAGGAGGA GCCCAACAGA GCAGCAGGGG 000960
000961 CTGGGGTCTT CTCCTGAAGC CTGACTCCAT GGGACCCCAA AGAAGCAGAT GGAAAACTGA AAAAGAAAAC CCCTCAAGTG 001040
001041 AGCCACTGGA AAGAAAGCAA AACAAGAGAA AATAAATGAG TTGTTTGACA TAAAAAAAAA AAAAAAAAA
Labs working on this lncRNA
- Department of Biochemistry and •õDivision of Urology, Department of Surgery, Saga Medical School, 5-1-1 Nabeshima, Saga, Saga 849-8507; [2][2].
- Max-Planck-Institut für Molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany.[3].
- Helmholtz‐Institute for Biomedical Engineering; Stem Cell Biology and Cellular Engineering; RWTH Aachen University Medical School, Aachen, Germany.[1]
References
- ↑ 1.0 1.1 Koch, C. M., and W. Wagner. "Epigenetic-Aging-Signature to Determine Age in Different Tissues." Aging (Albany NY) 3, no. 10 (2011): 1018-27.
- ↑ 2.0 2.1 2.2 2.3 2.4 Xin, Z., H. Soejima, K. Higashimoto, H. Yatsuki, X. Zhu, Y. Satoh, Z. Masaki, Y. Kaneko, Y. Jinno, R. Fukuzawa, Ji Hata, and T. Mukai. "A Novel Imprinted Gene, Kcnq1dn, within the Wt2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors." J Biochem 128, no. 5 (2000): 847-53.
- ↑ 3.0 3.1 S. Engemann, M.Strodicke, M. Paulsen, O. Franck, R. Reinhardt, N. Lane, W. Reik and J. Walter."Sequence and functional comparison in the Beckwith-Wiedemann region:implications for a novel imprinting centre and extended imprinting"
