PRAL
Contents
Annotated Information
Name
PRAL:p53 regulation associated lncRNA
LncRNA-PRAL[1]
Characteristics
LncRNA-PRAL is transcribed with a poly A1 tail, diffusely distributed both in the nucleus and cytoplasm, and localizes to both cytoplasmic and nuclear regions [1]. most of the sequence of the lncRNAPRAL overlaps in antisense with the 3' untranslated region of XAF1 protein-coding gene, which is known to regulate apoptosis[1].
Cellular Localization
LncRNA-PRAL (p53 regulation-associated lncRNA)localizes on chromosome 17p13.1[1].
Regulation
Function
LncRNA-PRAL could inhibit HCC growth and induce apoptosis in vivo and in vitro through p53. The three stem-loop motifs at the 50 end of lncRNA-PRAL facilitated the combination of HSP90 and p53 and thus competitively inhibited MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability[1].
Transfection of PRAL plasmid inhibits cell proliferation in NCI-H929 and A549 cells and promotes the transcription of P53[2].
Diseases
Labs working on this lncRNA
- Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China.
- The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, 200433, China.
- Department of Epidemiology, Second Military Medical University, Shanghai, 200433, China.[1]
- Department of Surgery, Xi'an Red Cross Hospital, Affiliated to School of Medicine, Xi'an Jiao Tong University, Xi'an, Shanxi, China(mainland).
- Maternal and Child Care Service Center of Changan District, Xi'an, Shanxi, China (mainland)[2].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Zhou CC, Yang F, Yuan SX, Ma JZ, Liu F, Yuan JH, Bi FR, Lin KY, Yin JH, Cao GW, Zhou WP, Wang F, Sun SH. Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma. Hepatology. 2016 Mar;63(3):850-63.
- ↑ 2.0 2.1 2.2 Su P, Wang F, Qi B, Wang T, Zhang S. P53 Regulation-Association Long Non-Coding RNA (LncRNA PRAL) Inhibits Cell Proliferation by Regulation of P53 in Human Lung Cancer. Med Sci Monit. 2017 Apr 11;23:1751-1758.
