FLNC-AS1

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Annotated Information

Name

FLNC-AS1:FLNC antisense RNA 1

ENST00000447565 [1]

Characteristics

ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA. [1]

Function

Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to inhibit the degradation of LIF mRNA mediated by other RNAs.[1]

Regulation

The expression ofΔNp63α can directly inhibitLIF mRNA transcription and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS.[1]

Diseases

Cervical squamous cancers[1]

Expression

ENST00000447565 is significantly downregulated expression in SiHa/ΔNp63αstable cell lines. In addition, Lnc-LIF-AS is also shown gradually up-regulated with the increase of ΔNp63α siRNAs. [1]

Labs working on this lncRNA

  • Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 Aug;96:114-122.