MHENCR

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Annotated Information

Name

MHENCR:melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489

Cellular Localization

MHENCR is predominantly localized in the cytoplasm of melanoma cells.[1]

Function

The effects of MHENCR on melanoma cell proliferation, cell cycle and apoptosis[1].

In vivo, MHENCR can play a role in pro-growth and pro-metastasis.[1] MHENCR knockdown significantly inhibits melanoma cells proliferation, induces cell cycle arrest and apoptosis, and also attenuates melanoma cells migration. In addition, Statistically significant correlations are also observed between MHENCR expression and IGF1 and SPIN1 in melanoma tissues. MHENCR as a competitively endogenous RNA, which specifically bound to miR-425 and miR-489, can upregulate their target genes IGF1 and SPIN1 expression, and further activate PI3K-Akt pathway. [1]

Expression

right|thumb|400px|Expression of MHENCR in melanoma and its association with melanoma patients’ prognosis[1]. The expression of MHENCR is upregulated in melanoma tissues and further upregulated in later stage and metastatic lesions. In addition, high expression of MHENCR is associated with poor prognosis of melanoma patients.[1]

Diseases

Melanoma[1]

Sequence

>NR_132417.1 Homo sapiens melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489 (MHENCR), transcript variant 1, long non-coding RNA

000001 CAGCTCCTAA CGCCGCAGGT TCCTCCTGGT CCCCGAGGCC CCCGGTCGGG CGTTGCCTGC CCCGCGCGGG CGGCCGGGCC 000080
000081 GAGGGACGAT GGTCAGTGGA CGGACGGCGC CAGGGAGCAG TGCCCACGCG CGGCAGGGCG GTACCTTCAG GCCTCCAGAG 000160
000161 GCTGGGGCTG GCTCTGTTGG CCTCTGTGCT GGGTTTCTTC CTCTGCACCG CAGGACTGGC TCTCCTGACC TCTCCAGGTG 000240
000241 TCATCGAACA CCCTTGTGCT TGCTGTCACC CGCTGCCTGT CTGCAGGATC CCGGATTCCG TATCAGGGGA CCGAAATTAG 000320
000321 TCGGAAAATA GGAAGCAGGT GCTCGCTTGG ATGGAACCCT GACCCTGTGC TCACACTTGT AGGAGGAGGG CTCTGCAGGC 000400
000401 CGCCTCCCGG AACGGGAGGT TCCCAAGCCA CTGCACTTCG GAGGGGCTGT AATTAGAGTT GCACATTCAT TCAGTTCCCA 000480
000481 GTAAAGTAGA ACGTGCTCCA GCCAGTGAGG AAAAGGTGTT TTTAAAAATT AGATTGGCCG AGTGCGGTGG CTCATGCCTT 000560
000561 TTACCTCAAC ACTTTGGGAG ACAAAGGTGG GAGGATCACC TGTGGCCAGG AGTTCAAGAC CAGCCTGGGC AACAGAGCCT 000640
000641 GTCTCTGGGG AAGAATAAAA AAAAAAATTG AGCCTTTGTC AGTGCTACTA TTTTATTATC TGGTAAATAT GAGAGGGTTC 000720
000721 ACGCGGTCTA TGTGTGTCAT TTATCTGAGT TTGCCTATCG TCACGTTTTG GAAATAAATG TCAATAAAGT CGA

Labs working on this lncRNA

  • Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Chen X, Dong H, Liu S, Yu L, Yan D, Yao X, Sun W, Han D, Gao G. Long noncoding RNA MHENCR promotes melanoma progression via regulating miR-425/489-mediated PI3K-Akt pathway. Am J Transl Res. 2017 Jan 15;9(1):90-102.
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