DM1-AS

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Annotated Information

Name

DM1-AS:DM1 locus antisense RNA

Characteristics

DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat. [1]

Cellular Localization

DM1-AS transcripts are present in the nucleus and in the cytoplasm.[1]

Expression

DM1-AS expression appears upregulated in patients, but transcript abundance remains very low in some tissues. In addition, DM1-AS expression was lowest in brain and highest in kidney, testis and muscle.[1]

Diseases

Myotonic dystrophy type 1[1]

Labs working on this lncRNA

  • a Radboud University Medical Center , Department of Cell Biology , Nijmegen , The Netherlands.

References

  1. ↑ 1.0 1.1 1.2 1.3 Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan 19:1-15.
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