XACT

Annotated Information

Approved Symbol

XACT

Approved Name

X active specific transcript (non-protein coding)

Disease

chromosome inactivation

Chromosome

Xq23

RefSeq ID

NR_131204

OMIM ID

300901

Ensembl ID

ENSG00000241743

Characteristics

XACT is a 251.8-kb transcription unit(112,983,323–113,235,148 bp) and it locates on chromosome Xq23 between the protein-coding genes AMOT and HTR2C . XACT is in an intergenic domain of 1.7 Mb .

Function

XACT has a role in the control of human XCI (X-chromosome inactivation) initiation .

(a)Localization of XACT and XIST on the human X chromosome (b)RT-PCR analysis (c,d,e)FISH analysis (f) Three-dimensional model of the nuclear volumes occupied by XACT and XIST RNAs.

Cellular Location

XACT is mostly in the nucleus.

Evolution

XACT is not conserved in mice .

Expression

XACT is expressed in both X chromosomes in humans but not in mice, and the expression of XACT is restricted to pluripotent cells .

pubmed IDs

23334669

Sequence

>gi|784642207|ref|NR_131204.1| Homo sapiens X active specific transcript (non-protein coding) (XACT), long non-coding RNA

000001 TTTGTGGATG AGTCAATGAA GAAACTTGTC AAAGCACTTC AATTAAAACA CAGAAACTAT AGAAAATCAT CTGGTAAACA 000080
000081 TGCTGATGAT GTCCTAAACC TGATCACTTG TCTCAAAATT TAGAAAGTTA ATGGCTGAAG ATTCAGCAGC CATTCTGAAC 000160
000161 TGGAAATTAC ATGTTAAGGC TGTTATAGAA GAAATAAAGA AATTAAATCT CTATGTCCCC AAGGTATCTC TATACCGGCC 000240
000241 TGGAATGCCT ATCTCCAAAC CTCCTTTACA TGAGACAGAA ACAGCTTCTA TCACCTTAAA ATCTGTTACT TTAGGTTTTT 000320
000321 TTCATTATGA GCAGCTAAAA TGAATCTTAC TTGATACAGT GTGAGTGTTC ATGGATTAGG GCATTGTTTG ATAAGAGGAG 000400
000401 TAAGAAAAGA ATATAAATTG TATTGGCCCT GATATGCCAC AAACAATGAG GGCTGAAGCC AAATTAATCA AAGAATAAAC 000480
000481 TCAAATACAA AGAACAAAAA AAAAAAAAA