KRT7-AS

From LncRNAWiki
Revision as of 09:01, 15 October 2017 by Lin Liu (talk | contribs)
Jump to: navigation, search

Annotated Information

Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.[1]
Regulatory function of KRT7-AS overexpression to KRT7.[1]
Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.[1]

Approved Symbol

KRT7-AS (KRT7 antisense RNA 1)

Chromosome

12q13.13

RefSeq

NG_012296

Characteristics

KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.[1]

Expression

In the same samples, KRT7 mRNA levels are much higher than KRT7-AS levels. In MKN28 and KATOIII cells, KRT7 mRNA is 61 and 41 fold higher than KRT7-AS (P<0.01).

Disease

gastric cancer

Labs working on this lncRNA

  • Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  • Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

References

  1. Jump up to: 1.0 1.1 1.2 1.3 Huang, B., et al., Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. Oncogene, 2016. 35(37): p. 4927-36.