CCND2-AS1

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Annotated Information

Name

CCND2-AS1:CCND2 antisense RNA 1

Function

[[ Knockdown CCND2-AS1 can inhibit the proliferation and colony formation, induce the cell cycle arrest in G0/G1 phase. And overexpression CCND2-AS1 promotes cell growth in normal human astrocyte. In addition, highly expressed CCND2-AS1 could enhance Wnt/b-catenin signaling in glioma. Taken together, LncRNA CCND2-AS1 can promote glioma cell proliferation through Wnt/b-catenin signaling [1]

Expression

The expression of lncRNA CCND2-AS1 is higher levels in glioma tissues Compared with adjacent normal brain tissues.[1]

Diseases

Gliomas[1]

Sequence

>NR_125790.1 Homo sapiens CCND2 antisense RNA 1 (CCND2-AS1), transcript variant 3, long non-coding RNA

000001 AATGCACAGC TTCTCCGCGG TCAGCGGGCT GGTCTCTTTG AGTTTGGAGG CCAGGAACAT GCAGACAGCA CCCAGGAGTT 000080
000081 GCAGATGGGA CTTCGGAGTC GGGACCCCAG CCAAGAAACG GTCCAGAAGA ATCTACCATA AAACCAACAG ACTCCTCCTG 000160
000161 ATCTCTACCT GTGCTGTCTG CCTCTCTAGT TCCGGACACT GAGAGCTGGT GCCCTGTGGC CACCTCAAGC TGGAACCCTG 000240
000241 CAAGATCACC AAGAAGACTG CATGCCTCGC TCTAGCCTTC CTAAGGGAAA GTAGACTCCT GTTTTTGAGA GAAATTACCT 000320
000321 GATTTCAAGA GAAACATAAA GGACTTTTTT TCCCTTAACA TTCCACTCGT AAAAATGAAG TTTGGAAGAA CTTCTGCAAA 000400
000401 CTCTGAGTGT TTTGGTCAAT TGACCTTTTA CTGTACTAAG CAAATCTGAA GCCACAAATA CATTGGGGAG GAAGGTATAC 000480
000481 CCTTCACAAA AGATCCGTCA CTTAGCCAGA TACTCTGTTG CCATGCTTCT TTAAATAAAG CACATTTCTG GTA

Labs working on this lncRNA

  • Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

References

  1. ↑ 1.0 1.1 1.2 Zhang H, Wei DL, Wan L, Yan SF, Sun YH. Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1219-1225.
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