LINC00520

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Annotated Information

LINC00520 is regulated by the PI3K pathway[1]
Expression Analysis in Clinical Samples of Human Breast Invasive Carcinoma[1]

Approved Symbol

LINC00520 (long intergenic non-protein coding RNA 520)

Previous Symbols

C14orf34

Chromosome

14q22.3

RefSeq(supplied by NCBI)

NR_026796

pubmed IDs

27626181

Characteristics

LINC00520 resides ~112kb from the kinesin receptor KTN1 and ~ 321kb from the Pellino E3 ubiquitin ligase family member 2, PELI2.[1]

Disease

breast cancer

Regulation

LINC00520 is regulated by STAT3 and the PI3K pathway in Src-transformed cells.[1]

Function

shRNA-mediated loss-of-function studies shows LINC00520 play roles in cell migration and invasion.[1] Overexpression of LINC00520 results in alterations in global gene expression.[1]

Expression

Compared with the wild-type PIK3CA-expressing cells, increased LINC00520 transcript levels are observed in MCF10A cells expressing mutant PIK3CA (H1047R).[1] LINC00520 is upregulated in human tumors and enriched in basal-like human breast carcinomas.[1]

Labs working on this lncRNA

  • Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Henry WS1, Hendrickson DG, et al., LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Oncotarget., 2016 Dec 13;7(50):81981-81994.