NONHSAT010191
DISC2, represent an important schizophrenia candidate gene in its own right.
Contents
Annotated Information
Approved Symbol
DISC2
Approved Name=
DISC2: Disrupted-In-Schizophrenia 2
Characteristics
DISC2 is located on the opposite strand to DISC1 and is transcribed in a distal to proximal orientation thus representing a natural antisense transcript (NAT). [1] DISC2, is an antisense RNA gene that overlaps exon 9 of DISC1, and with its 5′ located within DISC1 intron 9, but as yet not formally defined. [1][2] DISC2, along with DISC1 is identified as a gene disrupted by translocation in a family with schizophrenia.[1] DISC2 Contains a number of repeat sequences. SINEs, LINES and a DNA transposon. [1] Exact length and structure of DISC2 are not certain but described as unspliced and may be more than 15kb long Polyadenylated gene. [1]
Function
DISC2 is likely to modulate DISC1 expression but DISC2 functions independently of DISC1 and that its function may be independently important in the pathogenesis of schizophrenia. [3]
Regulation
Please input regulation information here.
Disease
Expression
Expression of DISC2 has been reported predominantly in human heart, where it produces multiple splice isoforms; however, it is expressed in brain at low levels. [1]
Labs working on this lncRNA
- Medical Genetics Section, Department of Medical Sciences,The University of Edinburgh,Edinburgh,UK.
- Merck Sharp and Dohme,The Neuroscience Research Centre,Terlings Park,Essex,UK.
- Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000; 9: 1415–1423.
- ↑ Millar JK, Christie S, Anderson S, Lawson D, Hsiao-Wei Loh D, Devon RS et al. Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. Mol Psychiatry 2001; 6: 173–178.
- ↑ 3.0 3.1 Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ & Millar JK. The DISC locus in psychiatric illness[J]. Mol Psychiatr. 2008, 13(1):36-64..
- ↑ Harries LW. Long non-coding RNAs and human disease[J]. Biochem Soc T. 2012, 40(902-906).
- ↑ Shi XF, Sun M, Liu HB, Yao YW & Song Y. Long non-coding RNAs: A new frontier in the study of human diseases[J]. Cancer Lett. 2013, 339(2):159-166.
Sequence
>gi|647979|ref|NR_002227.2|Homo sapiens disrupted in schizophrenia 2 (DISC2), long non-coding RNA
000001 CATAGGCAGT CTCCTGGTGC TCCACTTCTC TTCTCAGTCT GTTGTAATCT TCTTTAACAC TTCCCAGCTT TTTGACATTC 000080
000081 CTGGAACTCA ACACCAACAG CTTGCTGAGG AGTCCCTCCA GCCCTTCTCT CTCTGATGTT AATGATCTAA TCTCCTCGGT 000160
000161 GAGGTCTTTA GCCGTCCAGA AATGGTTTCC TACAGCACGT TGTGGGAGAG AAGAAGGGAA AACAAGCTTT ACAGCATCCA 000240
000241 CACACATGGA AGATCTAGCA GCAGCTAATG TACATTCACA GCATGGGCAA AGAAACTGCA CTTTGAGATT ATGTACAATT 000320
000321 TCCTTAGCAG TCCTCTGGGG AAAGAACCTG GAAAAATATT GCTCTCCTTA AACTGGAAAA ATCACCGTCT TTTTTATCAC 000400
000401 CTTATTCTTG TTATGTCCAT TTTAGGAGTT CCATTGGTGA AGCCATCTCC CGTAAAGTAT GATGACCCAA AAATGTCCCA 000480
000481 GTGGAATCCA GAGAAACCAC AATGTGTCAC TCCATTCCAA TAATATACAA ATGTCAAAGA GATGACATAT TATAGCAGTG 000560
000561 TGGAAGGGGA CTGGGCCATA TAATCAGAGT TGACCTAAAT TAAATTCCTC CCCTGTTACT CAAACTGTGT GACCTGGAGC 000640
000641 AAGAAAATTA GCACATCTGG GGCAAATTTC TTATAAAATA TAATTGCAAT AACACCTGAC TCATAGGTAG TTACAAGAAT 000720
000721 AAACAAGAAA TTCTGTAAAG CACTGAGAAA AATATATGAT AAATTAAATG TAGCAAGATT GCAGGATACA AGGTCAATGT 000800
000801 ACAAACATCA ATCTTATGTC TAAATAACAA AAAACTAGAA GATGATTTTT TAAAAAATAC AATTTACAAA ATATTTTAAA 000880
000881 TCTCATAATA CTGAGGGATA CTTTCTTTAA ATATGTGCAA GAGCTCTACA GTGAAAACTA TTTTTCAAAA ACTGCTGAGA 000960
000961 CAAATTAAAG ACAAATAATT TAAAAGATAC ACTGTATACA TACACTGGAA GTTCAATATT GGTAAGATTT CAATTTTCCC 001040
001041 CACATTGATT CATTGATTTA ATATAATTCC AATCAAAATG TTATGAGGTT CTTTTGTAGA AATTTATGTG CTTATTCTAA 001120
001121 AACGTCTAAG AGTGAGCTGG GCATGGTGGC TCACACCTGT AATCCCAGCA TTTTGGGAGG CCGAGGTGGT GGGTCCCTTG 001200
001201 AGGTCAGGTG TTCAAGACCA GCCTGGCCAA CATGGCGAAA CCCTATCTCT ACTAAAAATA TAAAAATTAA TCTGGCACAG 001280
001281 TGGTAAGCAC CTGTAATCCC AGCTACTCAA GAGGCTGAGG CAGGAGAATC ACTTAAACCC AGGAGGTGTA GGTTGCAGCG 001360
001361 AGCTGAGATC CTGCCACTGC ACTCCAGCTT GAGCAACAGA GTGAGACTTC ATATCTAAAC AAATAAAATC TAGAAGAATG 001440
001441 AGCCCATGAG TTTGAGGCTG TAGTGCACTA TGATTGCACT TTTGAACAGG CACTACACTC TTGTCTGGGC AACATAGCAA 001520
001521 GTCCCCACCT CAAAGAAGGA GAGGGAGAAA GAAGAAGAAG GAGGAGGAGG AGGTGAAAGA GGGAGGGAGG GAAGGAAGGA 001600
001601 GAAGACGAAG AAGAATGAAG AAGAATAGGA AGAAAGAAGA AGAAGGAAGA GGAGGAGGAG GATGACCAAA GCAATCCTTA 001680
001681 AAAAGTGAGT CTTGGTTTCA AGACTAATGC TAAAGCCACT ATAAATCAAG GTAATATGGC ATTGAATATA CATAGACAAA 001760
001761 CAGATCGATG GAATAGAATA AACAGTCCAG GAGTGGATTA ACACATATAC AGCCAACCAA AGTGCCAAAG CAAGTCAATG 001840
001841 AGGAAAAGAA AGTATTTTCA ATAAATGGTG CTGGAACAAC TAGCTATCTA CATGGAAAAA ATATTAACCT TGATTCATAC 001920
001921 CTCAAACCAC ACAAAAATTT AATTAAAGGT GGATCACAGG CCTACATGTA AAAGTTAAAA CTATAAAGCT TCTACAAAAA 002000
002001 AAAAATGAAT ATTTGATTGA CTTTGGAGTA GGCAAGAACT TCAGATAAGA TACAGAAAAC ACTATTTTAA AAAGGATAAA 002080
002081 TGGGCTTTAT CAAAATTAAA AACTTCTCAT CAAAAGACAC AACTAAAAAA TGAGACGACA AGTCACAGAC TTGGAGAAAA 002160
002161 TCATTGCATT ATGTTTAACT GACAAGGAAT TGAATACTAC AACTTGACAA TTAAAACACA AATGGTGCCA TTGAAAAATG 002240
002241 GTCAAATGAC TTAACAGGCA TTTTACAAAG TAGACGCACA AATGGCTAAT AAGCATATGA AAAAACATTT GACATCATTA 002320
002321 ATCATTAAGA AAAGAAAAAT TAAAACCATA AATATTCCAC TACAAGCCCA CTCAAATGTT TCAAATTAAC TCAACTAAAA 002400
002401 ATGTCAACAT TCACAAGGGT ATGGAGCAAC TGGAACTCTC ACGCATGTAA AATGGTCCCT TCAAGAAAAG TTCTGCCAGT 002480
002481 TTCTCATAAA GTTCAATGTA TACCTACCCT TTAATCCAAC AATTCTACTT CCAGGCATTT ACACAAAAGA AATGAAAACA 002560
002561 TGTCATCAAA AATATTTGCA CTCAAATAAA TGGTCACAGT GTCTTATGCC TGAGAGCCAG CCCCATACTG GAAGCAACCT 002640
002641 AAATATCCAT CAGCAGGAAG ATGCAAAAAT AATACTATAG CTATGCAATG AAAGACTACT CAGCAATAAA AAGAAACAAA 002720
002721 CTCGTCATAC ATGCAGCAAC ATGTATGTGT CTTTTTCTTT CTTTCTTTTT TTTTTTTTTG AGACAGAGTT TTGTTCTTGT 002800
002801 TGCCCAGGCT GGAGTGCAGT GGTACGATCT CAGCTCACTG CAACCTCCAC CTTCCAGTTT GAAACTATTC TCCTGCCTCA 002880
002881 GCCTCCCAAG TAGCTAGGAT TACAAGTGCC CACCACCACG CCCAGTTAAT TTTTGTATTT TTTAGTAGAG CCGGGGTTTC 002960
002961 ACCATGTTGG CCAGACTGTT CTCAAACTCC TGACCTCGTG ATCCACCCAC CTCAGCCTTC CAAAGTGCTG GGATTACAGG 003040
003041 CGTGAGCCAC CGCGCCCAGC CAACATGTAC ATGTCTTTAG AAAAGATGCA AAAGAGTAGT GCCACATGAT TCCATTAAGT 003120
003121 TCTAGAACAG CCAAAATTAA TCCATGGTAG AAGATATCAG AACAGAGGAG GGACGATGAT GACTGGGACA AGATAGGGTG 003200
003201 TTGTTTCTTG AGTGATGAGA CTGTTCTATC TCTTGGTAGG GCTGTTCGTA ACACAGGTGT CAAAATTCAA GAACTGTAAA 003280
003281 CACTTAAGAC CTGTGCATTC CACTGAATAT AAACCATACC TCAATTAAAA AGAGGAAAAA TTAAGAAATT TTTAAGCATG 003360
003361 AACATTGAAC AATAAATAAA TATATAACAT TAATGAGTGT CCCATAAATT AGTTAGTGTT AATTAGAAAA CCCCACTGTG 003440
003441 TTTTCTCAGA ATTTATAGTA ACCATAATCA CAATAATAGC TACAAACTTT CTCACCTTTA AATGTCATCA CAACTTTAGG 003520
003521 AAACAGGTTA TATCTTATAT TATTATTATT ATTATTATTA TTATTATTAT TATTATTATT TTACATTTTA ACATCTCTGA 003600
003601 AACAGGGATG TGTCCTACAA TCACCATCAG CCAGGAAGTG GTCAGGATGC AGTGGTTATA ACTGGATTAT TTTCCCTGGC 003680
003681 CTGGCTGACC ATCTGCAACC CCCTGGTGTT TCAATGTACA AACTATTTTA GGACCATCTG CGTACTGGCT GTTGCCTGAA 003760
003761 AATCTTGTGT TGATGTGGAT TTGTAAGACT GGGAAAGCAC CAGCATTCAA AACTTGAAGA AAGGTGTTAG CAGTTTGGCA 003840
003841 GACAATCCTA CAGAAAACTC TTTATTCTTG GGGGAGAAAA AGTTGCCTCC CA
000081 CTGGAACTCA ACACCAACAG CTTGCTGAGG AGTCCCTCCA GCCCTTCTCT CTCTGATGTT AATGATCTAA TCTCCTCGGT 000160
000161 GAGGTCTTTA GCCGTCCAGA AATGGTTTCC TACAGCACGT TGTGGGAGAG AAGAAGGGAA AACAAGCTTT ACAGCATCCA 000240
000241 CACACATGGA AGATCTAGCA GCAGCTAATG TACATTCACA GCATGGGCAA AGAAACTGCA CTTTGAGATT ATGTACAATT 000320
000321 TCCTTAGCAG TCCTCTGGGG AAAGAACCTG GAAAAATATT GCTCTCCTTA AACTGGAAAA ATCACCGTCT TTTTTATCAC 000400
000401 CTTATTCTTG TTATGTCCAT TTTAGGAGTT CCATTGGTGA AGCCATCTCC CGTAAAGTAT GATGACCCAA AAATGTCCCA 000480
000481 GTGGAATCCA GAGAAACCAC AATGTGTCAC TCCATTCCAA TAATATACAA ATGTCAAAGA GATGACATAT TATAGCAGTG 000560
000561 TGGAAGGGGA CTGGGCCATA TAATCAGAGT TGACCTAAAT TAAATTCCTC CCCTGTTACT CAAACTGTGT GACCTGGAGC 000640
000641 AAGAAAATTA GCACATCTGG GGCAAATTTC TTATAAAATA TAATTGCAAT AACACCTGAC TCATAGGTAG TTACAAGAAT 000720
000721 AAACAAGAAA TTCTGTAAAG CACTGAGAAA AATATATGAT AAATTAAATG TAGCAAGATT GCAGGATACA AGGTCAATGT 000800
000801 ACAAACATCA ATCTTATGTC TAAATAACAA AAAACTAGAA GATGATTTTT TAAAAAATAC AATTTACAAA ATATTTTAAA 000880
000881 TCTCATAATA CTGAGGGATA CTTTCTTTAA ATATGTGCAA GAGCTCTACA GTGAAAACTA TTTTTCAAAA ACTGCTGAGA 000960
000961 CAAATTAAAG ACAAATAATT TAAAAGATAC ACTGTATACA TACACTGGAA GTTCAATATT GGTAAGATTT CAATTTTCCC 001040
001041 CACATTGATT CATTGATTTA ATATAATTCC AATCAAAATG TTATGAGGTT CTTTTGTAGA AATTTATGTG CTTATTCTAA 001120
001121 AACGTCTAAG AGTGAGCTGG GCATGGTGGC TCACACCTGT AATCCCAGCA TTTTGGGAGG CCGAGGTGGT GGGTCCCTTG 001200
001201 AGGTCAGGTG TTCAAGACCA GCCTGGCCAA CATGGCGAAA CCCTATCTCT ACTAAAAATA TAAAAATTAA TCTGGCACAG 001280
001281 TGGTAAGCAC CTGTAATCCC AGCTACTCAA GAGGCTGAGG CAGGAGAATC ACTTAAACCC AGGAGGTGTA GGTTGCAGCG 001360
001361 AGCTGAGATC CTGCCACTGC ACTCCAGCTT GAGCAACAGA GTGAGACTTC ATATCTAAAC AAATAAAATC TAGAAGAATG 001440
001441 AGCCCATGAG TTTGAGGCTG TAGTGCACTA TGATTGCACT TTTGAACAGG CACTACACTC TTGTCTGGGC AACATAGCAA 001520
001521 GTCCCCACCT CAAAGAAGGA GAGGGAGAAA GAAGAAGAAG GAGGAGGAGG AGGTGAAAGA GGGAGGGAGG GAAGGAAGGA 001600
001601 GAAGACGAAG AAGAATGAAG AAGAATAGGA AGAAAGAAGA AGAAGGAAGA GGAGGAGGAG GATGACCAAA GCAATCCTTA 001680
001681 AAAAGTGAGT CTTGGTTTCA AGACTAATGC TAAAGCCACT ATAAATCAAG GTAATATGGC ATTGAATATA CATAGACAAA 001760
001761 CAGATCGATG GAATAGAATA AACAGTCCAG GAGTGGATTA ACACATATAC AGCCAACCAA AGTGCCAAAG CAAGTCAATG 001840
001841 AGGAAAAGAA AGTATTTTCA ATAAATGGTG CTGGAACAAC TAGCTATCTA CATGGAAAAA ATATTAACCT TGATTCATAC 001920
001921 CTCAAACCAC ACAAAAATTT AATTAAAGGT GGATCACAGG CCTACATGTA AAAGTTAAAA CTATAAAGCT TCTACAAAAA 002000
002001 AAAAATGAAT ATTTGATTGA CTTTGGAGTA GGCAAGAACT TCAGATAAGA TACAGAAAAC ACTATTTTAA AAAGGATAAA 002080
002081 TGGGCTTTAT CAAAATTAAA AACTTCTCAT CAAAAGACAC AACTAAAAAA TGAGACGACA AGTCACAGAC TTGGAGAAAA 002160
002161 TCATTGCATT ATGTTTAACT GACAAGGAAT TGAATACTAC AACTTGACAA TTAAAACACA AATGGTGCCA TTGAAAAATG 002240
002241 GTCAAATGAC TTAACAGGCA TTTTACAAAG TAGACGCACA AATGGCTAAT AAGCATATGA AAAAACATTT GACATCATTA 002320
002321 ATCATTAAGA AAAGAAAAAT TAAAACCATA AATATTCCAC TACAAGCCCA CTCAAATGTT TCAAATTAAC TCAACTAAAA 002400
002401 ATGTCAACAT TCACAAGGGT ATGGAGCAAC TGGAACTCTC ACGCATGTAA AATGGTCCCT TCAAGAAAAG TTCTGCCAGT 002480
002481 TTCTCATAAA GTTCAATGTA TACCTACCCT TTAATCCAAC AATTCTACTT CCAGGCATTT ACACAAAAGA AATGAAAACA 002560
002561 TGTCATCAAA AATATTTGCA CTCAAATAAA TGGTCACAGT GTCTTATGCC TGAGAGCCAG CCCCATACTG GAAGCAACCT 002640
002641 AAATATCCAT CAGCAGGAAG ATGCAAAAAT AATACTATAG CTATGCAATG AAAGACTACT CAGCAATAAA AAGAAACAAA 002720
002721 CTCGTCATAC ATGCAGCAAC ATGTATGTGT CTTTTTCTTT CTTTCTTTTT TTTTTTTTTG AGACAGAGTT TTGTTCTTGT 002800
002801 TGCCCAGGCT GGAGTGCAGT GGTACGATCT CAGCTCACTG CAACCTCCAC CTTCCAGTTT GAAACTATTC TCCTGCCTCA 002880
002881 GCCTCCCAAG TAGCTAGGAT TACAAGTGCC CACCACCACG CCCAGTTAAT TTTTGTATTT TTTAGTAGAG CCGGGGTTTC 002960
002961 ACCATGTTGG CCAGACTGTT CTCAAACTCC TGACCTCGTG ATCCACCCAC CTCAGCCTTC CAAAGTGCTG GGATTACAGG 003040
003041 CGTGAGCCAC CGCGCCCAGC CAACATGTAC ATGTCTTTAG AAAAGATGCA AAAGAGTAGT GCCACATGAT TCCATTAAGT 003120
003121 TCTAGAACAG CCAAAATTAA TCCATGGTAG AAGATATCAG AACAGAGGAG GGACGATGAT GACTGGGACA AGATAGGGTG 003200
003201 TTGTTTCTTG AGTGATGAGA CTGTTCTATC TCTTGGTAGG GCTGTTCGTA ACACAGGTGT CAAAATTCAA GAACTGTAAA 003280
003281 CACTTAAGAC CTGTGCATTC CACTGAATAT AAACCATACC TCAATTAAAA AGAGGAAAAA TTAAGAAATT TTTAAGCATG 003360
003361 AACATTGAAC AATAAATAAA TATATAACAT TAATGAGTGT CCCATAAATT AGTTAGTGTT AATTAGAAAA CCCCACTGTG 003440
003441 TTTTCTCAGA ATTTATAGTA ACCATAATCA CAATAATAGC TACAAACTTT CTCACCTTTA AATGTCATCA CAACTTTAGG 003520
003521 AAACAGGTTA TATCTTATAT TATTATTATT ATTATTATTA TTATTATTAT TATTATTATT TTACATTTTA ACATCTCTGA 003600
003601 AACAGGGATG TGTCCTACAA TCACCATCAG CCAGGAAGTG GTCAGGATGC AGTGGTTATA ACTGGATTAT TTTCCCTGGC 003680
003681 CTGGCTGACC ATCTGCAACC CCCTGGTGTT TCAATGTACA AACTATTTTA GGACCATCTG CGTACTGGCT GTTGCCTGAA 003760
003761 AATCTTGTGT TGATGTGGAT TTGTAAGACT GGGAAAGCAC CAGCATTCAA AACTTGAAGA AAGGTGTTAG CAGTTTGGCA 003840
003841 GACAATCCTA CAGAAAACTC TTTATTCTTG GGGGAGAAAA AGTTGCCTCC CA
