LncRNA-ATB

From LncRNAWiki
Revision as of 08:57, 5 November 2018 by Huma (talk | contribs) (Created page with "==Annotation== ===Name=== lncRNA-ATB ===Alias=== NA ===Disease=== Disease: colorectal cancer [http://www.ncbi.nlm.nih.gov/pubmed/26487301 (PMID:26487301)] Dysfunction type:...")
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Annotation

Name

lncRNA-ATB

Alias

NA

Disease

Disease: colorectal cancer (PMID:26487301)

Dysfunction type: interaction

Description: LncRNA-ATB was upregulated in colon cancer tissues compared with adjacent mucosa. LncRNA-ATB levels were also higher in metastatic cancer tissues. Among the three highly invasive colon cancer cell lines, lncRNA-ATB levels were relatively higher with concurrent low levels of E-cad compared with levels in the three low-invasive cell lines. LncRNA-ATB expression correlated with pN stage and AJCC stage. Striking differences were observed in overall survival and disease-free survival in cases with both high lncRNA-ATB expression and low E-cad expression. Reduction of lncRNA-ATB increased expression of epithelial markers E-cad, ZO-1, and decreased expression of mesenchymal markers ZEB1 and N-cadherin (N-cad), and significantly influenced colon cancer cell progression. Plasma lncRNA-ATB was upregulated in colon cancer patients one month after surgery.


Function

Function Mechanism: NA (PMID:27556453)

Biological Process: pathogenic process

Description: biomarker