LINC01561
lINC01561 inhibition suppresses the breast cancer (BC) cells proliferation and promotes the apoptosis.
Contents
Annotated Information
Name
LINC01561: long intergenic non-protein coding RNA 1561 (HGNC nomenclature)
Function
LINC01561 is highly expressed in BC cells and acts as a ceRNA of miR-145-5p, up-regulating miR-145-5p’s target gene MMP11. The inhibition of LINC01561 suppressed the growth of BC cells. This provides novel targets of BC [1].
It is inferred that LINC01561 might act as a ceRNA of miR-145-5p in BC, thereby imposes great influence on tumor growth [1].
Regulation
The down-regulation of LINC01561 markedly increases the miR-145-5p expression in mRNA level [1].
LINC01561 could up-regulate MMP11’s expression by the inhibition of miR-145-5p and LINC01561 was a ceRNA of miR-145-5p in BC [1].
The regulation of MMP11 by LINC01561 is of crucial important in BC. By competitive binding miR-145-5p, LINC01561 promotes the expression of MMP11 and the proliferation of the BC cells [1].
Diseases
- Breast cancer (BC) [1]
Expression
qRT-PCR results exhibited higher expressions of LINC01561 and MMP11 and lower expression of miR-145-5p in BC cell lines compared with normal cell line [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-GTTCTTCCATTCTGGGGGCA- 3' | 5'-CCTACTCAAGGGGCACATGG- 3'[1] |
Labs working on this lncRNA
- Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China. [1]
- Department of Opthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China. [1]
- Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China. [1]
- Department of Thyroid and Breast Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China. [1]
References
Sequence
>gi|404216|ref|NR_103717.1| Homo sapiens (HGNC nomenclature)(LINC01561), long non-coding RNA
000081 TCTGTGCAAT GGGTTCGTTC ATCCAATTTC CACCACTTTA CAGATGAACT GGGGATCAGA GAAGGCAAGC CACCTCCCCA 000160
000161 AGGTCACACA GCTTGTGAGA GCAAGACAAC AGCATCGAGG CCTATGTAAT AGCAGAGCCA TTGCTTCTTT GGCTCTGCGG 000240
000241 AAGCTTGTAT TGTGGTATAT CTGTGGTGTA GCTTTGCTGT CTCCTGTGTC AATGTCAGGA GGACAGGCTG AGCTCCTGGG 000320
000321 ACCAGAACCC CTCAGATTCC AGGAGGAGCA GAGAAAGCAC AGATGGCCTG GAGAGTCCCA GGGGTGAGGC CAGCAAGTAC 000400
000401 TTTCTTCCCC CAGGTGCTCA GAGCATCCTC TGAGTTGCCA AACAGACTCC CAGAGGGGTC AACTGTGGGC CCTAAACCAG 000480
000481 ACAGCAGCTG GGAAGCAGGC TCTCAGGGGA ACTGGGGTCT CACCAGCTCA GGAGCAGGCC AGGACTCCTC AGCACAGAAG 000560
000561 CTGGGAATCT TGAGTGTCCA GATCAGCCTG AAAATCTGGA CTTGGGAAAA GCCATCTGGC TGGGGCCACC TGCATGCCGC 000640
000641 TGTGACTGGG GCATCCTGCT GCTCTCCTCT CTCACAAGGT GGTGCCATCT GCCTTGTCAC TGCTCCTCAG GACAAGCCTG 000720
000721 ACTGCTCTCC CTGCACCTCT GGCCATTGAG AATCCGGCTG CTCCATCGTG GTGGAAAATC TTCCATGCTC AGAGGGACAC 000800
000801 CTTCCGACAC TGGGGTTCTG GAGAGCCTGG TGCCACGAGA CAAGGAGCCA TGTGACAAGA GGGGGAGGGG TAGGAGTGGG 000880
000881 AGACACAAGT GTGGTTTGGG ACAAAATAGG GCCTGAGGCT CACGTGTTAT AAAACCCCCT TTGCTCTGCC TGTCTCCTTG 000960
000961 AATTGTGGCC AGTTTCACAT GGGAAGCAAC GTCGAGGGAC AGGGAGACTG CAGGTGAGGC CTCAGGGCTC TGCATTCCCA 001040
001041 TCCCCAAAAG TCACCAGCGT GTGGCCTTGT GGGTGTCACT CCCCTCTGTG GAGTCAACTT TGTGCAGTGA CATGCAGAGG 001120
001121 CTGGACTGCT GCCACCTCAT GCCCCTCCTG GCATGATGGT CGCATGAGGC TGAGTGATTT GCAGGTCTAT GGGGAAACCC 001200
001201 GCCTCAGAGA TGTGGAGGAG AAGCCAGGCA GAGCGCTGTT CATTCCATTT CTTTCTTTTT TTAATCTAAA GGAGGGAAAG 001280
001281 AGCTTTATTA ACTCAAACAA AGGGATGCCA TACAACTTCC CAACGATACT GTGCAGTGAT GGTATTAGCT TCCACCTGTT 001360
001361 CTTCCATTCT GGGGGCAGGG TGTGAGGACT GGCTGCTCTG GGAGACGCTC TGAGCTGAGA GAGAAGAAAT AGCTATGCTA 001440
001441 ATAGCTGCCC CTTACTGAGT GCTCACTCTG TGTCCGGGGC TACACCGAGT GCTTGCAGCG GGTTCTCAGG CGCACTTAGA 001520
001521 ACAGCACTGT GAGAAAGGCA CTTTTGCTGC CCCTTGTGTA CAGATGAGGA CAAAGAGGGA CAGAGAGGTT TAGAACCTTG 001600
001601 ACCTATATCA CACAGCCAGT GAGCAGACGA CCGGAATTTG AATCCTGCAA TCTCTCTGCA GAGCCTGCGC ATTTAATACC 001680
001681 ACACACAGTT CTGGCCTGCA GTGAATTTGG TTGTTCTTCC TGCCTGGGGT GGTCAGTTTC CAAGCCTTTC CAGATGGACT 001760
001761 TCTGCAGCCC AAAGCTGCGT GCTCCCCGTG CAGGCCCTTG TCAGAGCAGA GAAAGATGGC TGAAGTTGTT GTCCATCTAG 001840
001841 ATTTTTATCT TCAAAACATT GCTGAAATCA ATCTCTCTTC TACCGTCTCC GATTTCCTTT GTCCTTATGG GTGGTCTACA 001920
001921 ACTTTACTAT CATTTTAGTG GATGCAAGAG GAGTGGAGAT AAACACGTGT TCAGCCTGCT GTGAATCTCT GCAGTGGCTA 002000
002001 TGTTGTTTCT TAAACAGATG TAATGAGGCA TCTATTCCCT GTGTGCCATG TGCCCCTTGA GTAGGGGACA TCTGTTTTGT 002080
002081 GTTGTCTGTG TCTCCAGCAT TAGAATGGAA CCTGGCACAC AATAGAGGCT CAATTAGTAT TTGTTGAATA AATGAACATT 002160
002161 AAGAAACAGA AAAGAAAAAA AAAAAA
