IATPR
IATPR is a long non-coding RNA and could be a potential biomarker in the prognosis of breast cancer.
Contents
Annotated Information
Name
IATPR: ITGB1 adjacent tumor promoting lncRNA (HGNC nomenclature).
Characteristics
IATPR has a chromosomal location of 10p11.22 (HGNC data).
Function
Functional analysis shows that knockdown of IATPR significantly inhibits gallbladder cancer cell proliferation [1]. IATPR potentially promotes gallbladder cancer invasion and metastasis by accelerating the process of epithelial-to-mesenchymal transition, and the application of RNA interference targeting linc-ITGB1 might be a potential form of gallbladder cancer treatment in advanced cases [1]. IATPR also promotes breast cancer progression by inducing cell cycle arrest and interrupting the epithelial-to-mesenchymal transition process [2].
Regulation
Please input information here.
Diseases
Expression
IATPR levels were lower in tumor tissues of BC patients in comparison to adjacent non-cancerous breast tissues (p < 0.001). Linc-ITGB1 expression was significantly associated with lymph node metastasis, pathological differentiation and TNM stage (all p < 0.05)[3]. However, further studies are required to establish lincRNA-ITGB1 expression and clinicopathological features in GBC cases [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-CCTCTCAGCCTCCAGCGTTG- 3' | 5'-TGCTCTTGCTCACTCACACTCC- 3'[1] |
| qRT-PCR | 5'-CCTCTCAGCCTCCAGCGTTG- 3' | 5'-TTGCTCTTGCTCACTCACACTCC- 3'[3] |
Labs working on this lncRNA
- Department of General Surgery, Xinhua Hospital, Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, China. [1]
- Breast Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. [3]
- Department of General Surgery, Ningbo No. 7 Hospital, Ningbo, Zhejiang, People's Republic of China. [2]
- Department of Preventive Medicine, Ningbo University, Ningbo, Zhejiang, People's Republic of China. [2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Wang L, Zhang Y, Lv W, Lu J, Mu J, Liu Y, Dong P. Long Non‐coding RNA Linc‐ITGB 1 Knockdown Inhibits Cell Migration and Invasion in GBC‐SD/M and GBC‐SD Gallbladder Cancer Cell Lines. Chemical biology & drug design. 2015, 86(5):1064-71.
- ↑ 2.0 2.1 2.2 2.3 Yan M, Zhang L, Li G, Xiao S, Dai J, Cen X. Long noncoding RNA linc‐ITGB1 promotes cell migration and invasion in human breast cancer. Biotechnology and applied biochemistry. 2017, 64(1):5-13.
- ↑ 3.0 3.1 3.2 3.3 3.4 Li WX, Sha RL, Bao JQ, Luan W, Su RL, Sun SR. Expression of long non-coding RNA linc-ITGB1 in breast cancer and its influence on prognosis and survival. Eur. Rev. Med. Pharmacol. Sci. 2017, 21:3397-401.
Sequence
>gi|101929447|ref|NR_160030.1| Homo sapiens ITGB1 adjacent tumor promoting lncRNA (IATPR), long non-coding RNA
000081 TCTGGACTGA ATGGGCTCAA GTCATCTAGT TAACCTCTCT GGATTTCAGT CTTCTGAAAA GTGAAGCTAA GAGATCTAGC 000160
000161 ATTCTGCAGA AAAGTACTGG AGATGACTCA GGACTGAAAA TGATCATGAA GCCCCTTTGC AAATATCAAA GTGGTGATGA 000240
000241 AGCAGTCATG AACTTTGACC AGAAGCCGTG TTTTGTGGGA TTGCCACTTT AATCGCTCCT GTTCATCATT AGGACTGCAG 000320
000321 CCAGAGTGTG GAAGGAGTGA CAGCACAGAG GAAGAGATGG TCCAAGACCA AAGAGGAAAG AAATGGCATA AGATGGGACA 000400
000401 GTGTTCTATG ATCTCTAACT GGCCAAAGAA AAATGAGAAA CAAATTTAAA AGAAGACAGT TGGATGACTT AAACACCACC 000480
000481 CCTGAGAGGC AGCTGTTTCC AGAATATTGC ACAATTTATT GAGTTCATGA GAATCGTGAT CGTTGGCAGC ACCGAACTTC 000560
000561 ACGGAGGGAA TCATAGGCAC TTTAATTCCA ATTTGTTGAC TTATGGAGGA AGAAATTTCT CCCAGTGGTG TCCCTTCATC 000640
000641 CAGGAACAAG AGCCATCAAA GTGTCACAGA CTTAGAGCCG
