SCAT2

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SCAT2 is a long non-coding RNA that modulate cell cycle progression and cell proliferation.

Annotated Information

Name

SCAT2: S-phase cancer associated transcript 2 [1], CBX5-AS1 (HGNC nomenclature).

Characteristics

SCAT2 is 735 bp long non-coding RNA, located on chromosome chr12q13.13 (HGNC) [1].

Function

Oncogenic functions of EPIC1 in breast cancer. [1]

Higher expression of all SCATs is correlated with poor overall survival [1].

Downregulation or overexpression of SCATs affected cancer cell hallmarks such as cell cycle progression, cell proliferation, apoptosis, cellular senescence, and cell invasion/migration, indicating that our cell cycle-based functional screen identified potential oncogenic drivers [1].

Expression

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Regulation

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Diseases

  • kidney clear cell carcinoma [1]

Labs working on this lncRNA

  • Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530 Sweden.[1]
  • Department of Pediatrics, Institution for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530 Sweden.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Ali MM, Akhade VS, Kosalai ST, Subhash S, Statello L, Meryet-Figuiere M et al. PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers[J]. Nat Commun. 2018, 9(1):883.

Sequence

>gi|112935960|ref|NR_157844.1| Homo sapiens S-phase cancer associated transcript 2 (SCAT2), long non-coding RNA

000001 AGGAGCAGCA GTAAGAAATG AGAAATGCAC TCAGACATCG GAGGGGACAT AATTCTCTTT TAGACAGTGT GACCCGGAGT 000080
000081 ATTAGGGTCA AATGAAACAC AAAGCCAGTC AAACAATTTA AGGGCTAGAG CCTAGACCAG ATAAAGCATC AAGACTGGTG 000160
000161 GTTCACACTG AGCTTAGGAG GAGGGAGCTT TCCAGCATGA GAAATGAGAC ATGGCTGGCA GGATGATGGA GTGATTAAGA 000240
000241 TAGAATCCCA ATACCATGAC AGAGGAAAAG AAGATGAGCC TCTGAACACA ACCTTATCCT TGTGGAAATC TCCAAGGGAA 000320
000321 AGGATCCTGG AATAAGCAGA GTGGGCATTA CCAAAAGGAG ATAGACTGCA TGTAAAACAC ACTTCGAAGG AAATCTAATT 000400
000401 AAAAGGCAAG GAATAATCCA GGTGATGGAT GAATCTTCTG TCCCCAGAAC CCTAAATATT ACCCTCTTTG TTTCTTTTTT 000480
000481 ATTCCAAAGT CAGATATCCT CAAAGGAACA GCAAAAAGAG GGACTTTAGG ATATCTTCAA TGGTGTAAAG AAAAGAAATA 000560
000561 TATGAAAGTT CCCGGGAGAA AGAGACTAAA ATAAAAGCAC TGGGCACATG GATTACATAA AACAGAAAAG GGGTTGTAAG 000640
000641 TATGTGATTA TGACTAGAAA CACAAAACAA TCGACTTCAT TTTTTATTTA ATTTTAATCA CAAATTATTA ACCTTGCAAA 000720
000721 GTTTTAAACA TTAAA
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