CDRT3
Contents
Annotated Information
Name
Approved symbol: CDRT3
Approved name: CMT1A duplicated region transcript 3
HGNC ID: HGNC:14382
RefSeq ID: NR_146601
Characteristics
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Expression
The highly expressed in primary mouse hepatocytes treated with GW3965((Sallam T 2016)) and upregulated in OS(Osteosarcoma) tissues((Wang G 2017)).
Regulation
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Function
LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism((Sallam T 2016)).
LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth((Wang G 2017)).
Disease
- osteosarcoma
- colon adenocarcinoma [1]
Evolution
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Labs working on this lncRNA
- No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
- Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.
References
- ↑ Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.
